Myomaker和Myomerger调控成肌细胞融合的分子机制

doi:10.16288/j.yczz.19-232

遗传 ›› 2019, Vol. 41 ›› Issue (12): 1110-1118.doi: 10.16288/j.yczz.19-232

Myomaker和Myomerger调控成肌细胞融合的分子机制

朱艳¹, 张进威¹, 齐婧¹, 李学伟¹, 陈磊², 李明洲¹, 马继登¹()

^1. 四川农业大学动物科技学院,畜禽遗传资源发掘与创新利用四川省重点实验室,成都 611130
^2. 重庆市畜牧科学院,重庆 402460

收稿日期:2019-08-08 修回日期:2019-10-25 出版日期:2019-12-20 发布日期:2019-12-05
通讯作者: 马继登 E-mail:jideng.ma@sicau.edu.cn
作者简介:朱艳,硕士研究生,专业方向：动物遗传育种与繁殖。E-mail:zhuyan_494062079@163.com
基金资助:
四川省省院省校科技合作研发项目编号(2017JZ0025);四川省科技支持计划项目编号(2016NYZ0042);四川省科技支持计划项目编号(2017NZDZX0002);重庆市农业发展基金会项目编号(12404);重庆市农业发展基金会项目编号(17430);四川省科技厅重点研发项目资助编号(2019YFN0035)

Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion

Yan Zhu¹, Jinwei Zhang¹, Jing Qi¹, Xuewei Li¹, Lei Chen², Mingzhou Li¹, Jideng Ma¹()

^1. Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
^2. Chongqing Academy of Animal Sciences, Chongqing 402460, China

Received:2019-08-08 Revised:2019-10-25 Online:2019-12-20 Published:2019-12-05
Contact: Ma Jideng E-mail:jideng.ma@sicau.edu.cn
Supported by:
Supported by Research and Development Project of Scientific and Technological Cooperation between Sichuan Provincial Colleges and Universities No(2017JZ0025);the Science and Technology Support Program of Sichuan Nos(2016NYZ0042);the Science and Technology Support Program of Sichuan Nos.(2017NZDZX0002);Chongqing Agricultural Development Foundation Nos(12404);Chongqing Agricultural Development Foundation Nos(17430);the Key Research and Development Projects of Sichuan Science and Technology Department No(2019YFN0035)

摘要/Abstract

摘要：

骨骼肌形成是一个复杂的生理过程,主要涉及肌源性干细胞增殖形成成肌细胞,进而分化、融合形成多核肌管。研究发现,有多种蛋白参与成肌细胞融合过程,但它们均不具有肌肉特异性。近年来,两种肌肉特异性膜蛋白Myomaker和Myomerger先后被发现和鉴定,它们能协调促进成肌细胞融合,从而参与骨骼肌形成过程。本文对成肌过程中Myomaker和Myomerger的表达模式、功能域等研究现状及其参与成肌细胞的融合机制进行了综述,旨在为深入研究骨骼肌形成过程及治疗肌细胞融合相关疾病提供参考信息。

关键词: 骨骼肌形成, Myomaker, Myomerger, 细胞融合

Abstract:

Myogenesis is a complex physiological process that is mainly involved in the proliferation of myogenic stem cells to form myoblasts, which then differentiated and fused to form multinucleated myotubes. Many proteins have been found to be involved in myoblast fusion, but none of them are muscle-specific fusion proteins. In recent years, two muscle-specific transmembrane proteins, i.e. Myomaker and Myomerger, have been discovered and identified, which can coordinate and promote the fusion of myoblasts and thus participate in the process of myogenesis. In this review, we summarize the research progress of Myomaker and Myomerger in myogenesis, including their expression patterns and functional domains, as well as their participation in myoblast fusion mechanisms, aiming to provide relevant ideas for in-depth study of the myogenesis process and treatment of diseases related to myoblast fusion.

Key words: myogenesis, Myomaker, Myomerger, myoblast fusion

朱艳, 张进威, 齐婧, 李学伟, 陈磊, 李明洲, 马继登. Myomaker和Myomerger调控成肌细胞融合的分子机制[J]. 遗传, 2019, 41(12): 1110-1118.

Yan Zhu, Jinwei Zhang, Jing Qi, Xuewei Li, Lei Chen, Mingzhou Li, Jideng Ma. Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion[J]. Hereditas(Beijing), 2019, 41(12): 1110-1118.

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基因	物种	染色体位置	可变剪接体数	转录ID	外显子数	转录长度 (bp)	翻译长度 (aa)	参考文献
Myomaker	小鼠 (M. musculus)	Chr.2:27061636-27072179	2	ENSMUST00000009358.2	5	1382	221	[5~7,29]
	小鼠 (M. musculus)	Chr.2:27061636-27072179	2	ENSMUST00000163967.1	5	1210	180	[5~7,29]
	人 (H. sapiens)	Chr.9:136379708-136393734	2	ENST00000339996.3	5	818	221	[28]
	人 (H. sapiens)	Chr.9:136379708-136393734	2	ENST00000413714.1	0	531	-	[28]
	斑马鱼 (D. rerio)	Chr.5:68934948-68940186	2	ENSDART00000033962.6	5	663	220	[23]
	斑马鱼 (D. rerio)	Chr.5:68934948-68940186	2	ENSDART00000138519.1	1	258	45	[23]
	鸡 (G. gallus)	Chr.17:6958313-6965254	1	ENSGALT00000034784.3	5	1078	220	[27]
Myomerger	小鼠 (M. musculus)	Chr.17: 45600967-45602102	3	ENSMUST00000113529.2	1	811	84	[8,9,25]
				ENSMUST00000169137.1	2	852	18
				ENSMUST00000178858.1	1	808	84
	大鼠 (R. norvegicus)	Chr.9: 16670994-16671263	1	ENSRNOT00000064497.2	1	270	89	-
	人 (H. sapiens)	Chr.6: 44216939-44218236	2	ENST00000573382.2	1	817	84	-
	人 (H. sapiens)	Chr.6: 44216939-44218236	2	ENST00000576476.1	1	682	84	-

Myomaker和Myomerger调控成肌细胞融合的分子机制

Molecular regulation mechanism of Myomaker and Myomerger in myoblast fusion

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