关键词: 链霉菌, 底盘细胞, 天然产物

Abstract: The genus Streptomyces offer a wealth of nature products with diverse structures, accounting for more than two-thirds of natural antibiotics. However, the original Streptomyces producers of desired natural products is technically challenging due to their harsh cultivation conditions, slow growth rate and intricate genetic backgrounds, and the metabolites of Streptomyces caused interference with the extraction of the target natural products. Thus, an ideal Streptomyces chassis with characterization of clean metabolic background, fluent genetic manipulation, and higher success rate of BGC expressions is urgent need to developed, which can largely increased yield and reduce production costs. We summarized the chassis develop in Streptomyces, as well as the important role in the excavation and production of natural products, with focus on its potential for discover and synthesis of nature products.

Key words: Streptomyces, Chassis engineering, Natural products