MT1-MMP在肿瘤转移中的研究进展

doi:10.16288/j.yczz.22-213

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Hereditas(Beijing) ›› 2022, Vol. 44 ›› Issue (9): 745-755.doi: 10.16288/j.yczz.22-213

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Progress on the role and mechanism of MT1-MMP in tumor metastasis

Qinggang Hao¹(), Fenggui Sun², Chenghao Yan¹, Jianwei Sun¹()

1. Center for life Sciences, School of life Sciences, Yunnan University, Kunming 650504, China
2. Department of Hearing Screening Room, Shouguang People's Hospital of Shandong Province, Shouguang 262750, China

Received:2022-06-22 Revised:2022-08-01 Online:2022-09-20 Published:2022-08-15
Contact: Sun Jianwei E-mail:haoqinggang@yeah.net;jwsun@ynu.edu.cn
Supported by:
Supported by the Applied Basic Research Foundation of Yunnan Province Nos(202101AV070002);Supported by the Applied Basic Research Foundation of Yunnan Province Nos(2019FY003030);the Major Science and Technique Programs in Yunnan Province No(202102AA310055);the 13th Graduate Scientific Research Innovation Project of Yunnan University No(2021Z088)

Abstract

Abstract:

The matrix metallopeptidase family (matrix metallopeptidase, MMPs) is a class of zinc-dependent endopeptidases that can degrade most extracellular matrices. MT1-MMP (membrane type 1 metalloprotease) is an important metallopeptidase, which is located on plasma membrane and highly expressed in most tumors. MT1-MMP promotes cancer metastasis through affecting the extracellular matrix remodeling, angiogenesis, lipid metabolism, and inflammation. However, the mechanisms of MT1-MMP in different tumors have not been fully elucidated. In this review, we summarize the latest progress and the metastasis-promoting regulatory mechanisms of MT1-MMP in different tumors, which will provide references for its in-depth research and application in the field of cancer biology.

Key words: MT1-MMP, tumor, metastasis, trafficking, recycling

Qinggang Hao, Fenggui Sun, Chenghao Yan, Jianwei Sun. Progress on the role and mechanism of MT1-MMP in tumor metastasis[J]. Hereditas(Beijing), 2022, 44(9): 745-755.

Figures/Tables 2

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