组蛋白赖氨酸甲基化修饰与先天性心脏病研究进展

doi:10.3724/SP.J.1005.2010.00650

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (7): 650-655.doi: 10.3724/SP.J.1005.2010.00650

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Research progress in modification of histone lysine methylation and congenital heart defect

SHENG Wei^{1, 2}, MA Duan¹

1. Key Laboratory of Molecular Medicine, Ministry of Education,Shanghai Medical College, Fudan University, Birth Defects Research Center, Fudan University, Shanghai 200053, China; 2. College of Life Science, Anhui Science and Technology University, Fengyang 200032, China

Received:2009-10-28 Revised:2010-01-12 Online:2010-07-20 Published:2010-07-20
Contact: MA Duan E-mail:duanma@shmu.edu.cn

Abstract

Abstract: Histone modification is an important component of epigenetic regulation, which can regulate eukaryotic gene expression by changing the structure of chromatin and interacting with other regulatory proteins. Abnormal histone modifications may lead to a variety of diseases, while the reversibility of histone modification provides a new way of thinking for treatment of these diseases. In this paper, we discussed the mechanism of histone lysine methylation related to congenital heart defect in order to provide a useful reference for researchers working in this area.

Key words: epigenetic regulation, istone methylation, ongenital heart defect

CHENG Wei, MA Duan. Research progress in modification of histone lysine methylation and congenital heart defect[J]. HEREDITAS, 2010, 32(7): 650-655.

References

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Research progress in modification of histone lysine methylation and congenital heart defect

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