一个新的细胞死亡形式: Parthanatos

doi:10.3724/SP.J.1005.2010.00881

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (9): 881-885.doi: 10.3724/SP.J.1005.2010.00881

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A new form of cell death: Parthanatos

WANG Lian-Bang, ZHANG Li-Ying, SHAN Chun-Hua

Laboratory of Development Biology, College of Life Science, Northeast Forestry University, Harbin 150040, China

Received:2009-11-26 Revised:2010-01-20 Online:2010-09-20 Published:2010-09-20
Contact: SHAN Chun-Hua E-mail:chhshan@sina.com

Abstract

Abstract: Parthanatos is a form of cell death, which often occurs in many diseases such as stroke, Parkinson’s disease, heart attack, diabetes, and ischemia reperfusion injury. In a cell, the activation of PARP-1 caused by excitotoxicity leads to Parthanatos, which is also known as PARP-1-dependent cell death. There are multiple cell signaling pathways involved in the process of Parthanatos, which have not been fully understood. The main focus of this article is underlying molecular mechanisms of Parthanatos.

Key words: Parthanatos, PARP-1, PAR, AIF, cell death

WANG Lian-Bang, ZHANG Li-Yang, CHAN Chun-Hua. A new form of cell death: Parthanatos[J]. HEREDITAS, 2010, 32(9): 881-885.

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A new form of cell death: Parthanatos

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