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HEREDITAS ›› 2010, Vol. 32 ›› Issue (9): 874-880.doi: 10.3724/SP.J.1005.2010.00874

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Research and application of microRNA evolution and regulation

WANG Tian-Yu1, 2, DONG Yuan-Yuan1, LI Hai-Yan1, LI Xiao-Kun1   

  1. 1. Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun 130118, 2. College of Life Science, Jilin Agricultural University, Changchun 130118, China
  • Received:2009-12-31 Revised:2010-02-24 Online:2010-09-20 Published:2010-09-20
  • Contact: LI Hai-Yan; LI Xiao-Kun E-mail:hyli99@163.com;xiaokunli@163.net

Abstract: MicroRNAs, a type of small non-coding RNA specialized in regulation of gene expression, extensively participate in biological development, cell differentiation, apoptosis, and other cellular processes. MiRNAs evolved independently in different strains and generally conserved in the process of evolution. This review summarized the origin, regulation of methylation, and evolutionary conservation of miRNAs. In addition, application of miRNAs in diseases, animals and plants was discussed.

Key words: miRNA, microRNA evolution, DNA methylation