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HEREDITAS ›› 2011, Vol. 33 ›› Issue (4): 285-292.doi: 10.3724/SP.J.1005.2011.00285

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Advances in effector protein of histone methylation

SONG Bo-Yan, ZHU Wei-Guo   

  1. Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing 100191, China
  • Received:2010-09-25 Revised:2010-12-20 Online:2011-04-20 Published:2011-04-25
  • Contact: ZHU Wei-Guo E-mail:zhuweiguo@bjmu.edu.cn

Abstract: As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biological processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effector proteins recognize modification sites specifically, and affect gene transcriptional process. This review mainly focuses on recent advances in histone methylation effector protein’s function mechanism.

Key words: epigenetics, effector protein of methylated histone, histone modification, gene transcription regulation