羊重要性状全基因组关联分析研究进展

doi:10.16288/j.yczz.17-021

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (6): 491-500.doi: 10.16288/j.yczz.17-021

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Advances in genome-wide association studies for important traits in sheep and goats

Tongyu Zhang(),Caiye Zhu,Lixin Du(),Fuping Zhao()

Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2017-01-16 Revised:2017-02-16 Online:2017-06-20 Published:2017-03-20
Supported by:
the National Natural Science Foundation of China(31572357);National Program for Science and Technology Development(2015BAD03B0503);Agricultural Science and Technology Innovation Program(ASTIP-IAS-TS-6)

Abstract

Abstract:

Genome-wide association study (GWAS), an effective strategy to identify genetic variants associated with complex traits, has been used to study candidate genes of economical traits in animals. With the recent completion of sheep and goat genomes, single nucleotide polymorphism (SNP) chips of different densities are developed and commercialized. All these advances have enlarged the collection of molecular markers and also shed new light on the genetics of traits of interest in sheep and goats. In this review, we focus on the adoption of GWAS for important traits in sheep and goats, such as horn types, wool, dairy, growth and meat, reproduction and disease types, etc., and summarize the populations, major statistical methods and results of the GWAS analysis. Moreover, we also discuss the current state of GWAS, aiming to provide a reference for further studies on the genetic background of the important traits of sheep and goats by GWAS.

Key words: GWAS, genome, SNP, complex trait, sheep and goats

Tongyu Zhang,Caiye Zhu,Lixin Du,Fuping Zhao. Advances in genome-wide association studies for important traits in sheep and goats[J]. Hereditas(Beijing), 2017, 39(6): 491-500.

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