人microRNA相关的遗传变异与肿瘤

doi:10.3724/SP.J.1005.2011.00870

[an error occurred while processing this directive]

HEREDITAS ›› 2011, Vol. 33 ›› Issue (8): 870-878.doi: 10.3724/SP.J.1005.2011.00870

• en • Previous Articles Next Articles

Association of human microRNA related genetic variations with cancer

LI Pei-Yao^{1, 2}, HE Fu-Chu^{1, 2}, ZHOU Gang-Qiao^{1, 2}

1. Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China 2. Department of Functional Genomics, Beijing Proteome Research Center, Beijing 102206, China

Received:2011-04-01 Revised:2011-05-25 Online:2011-08-20 Published:2011-08-25

Abstract

Abstract: microRNAs (miRNAs) are a highly conserved class of small noncoding RNAs that regulate gene expression by post-transcriptional degradation or translational repression. miRNAs are involved in the regulation of cell apoptosis, prolif-eration, differentiation and other physiological processes, and are closely related with the development of cancer. More recently, it has been proposed that the presence of genetic variations (e.g., single nucleotide polymorphism and copy num-ber variation) in microRNA genes, their biogenesis pathway and target binding sites affect the miRNA processing machin-ery and targeting, and have a significant genetic effect. In this review, we focus on the miRNA-related genetic variations and cancer susceptibility and progression.

Key words: microRNA, polymorphism, copy number variation, cancer

CLC Number:

Q347

LI Pei-Yao, HE Fu-Chu, ZHOU Gang-Qiao. Association of human microRNA related genetic variations with cancer[J]. HEREDITAS, 2011, 33(8): 870-878.

References

[1] The International HapMap Consortium. A haplotype map of the human genome. Nature, 2005, 437(7063): 1299-1320.
[2] Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science, 2001, 294(5543): 853-858.
[3] Yuan XY, Liu CN, Yang PC, He SM, Liao Q, Kang SL, Zhao Y. Clustered microRNAs' coordination in regulating protein-protein interaction network. BMC Syst Biol, 2009, 3: 65.
[4] Lee Y, Jeon K, Lee JT, Kim S, Kim VN. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J, 2002, 21(17): 4663-4670.
[5] Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res, 2004, 14(10A): 1902-1910.
[6] Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC. The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell, 2007, 130(1): 89-100.
[7] Saunders MA, Liang H, Li WH. Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci USA, 2007, 104(9): 3300-3305.
[8] Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2): 281-297.
[9] Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med, 2005, 353(17): 1793-1801.
[10] Wu MQ, Jolicoeur N, Li Z, Zhang LH, Fortin Y, L'Abbe D, Yu ZB, Shen SH. Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis, 2008, 29(9): 1710-1716.
[11] Yang HS, Dinney CP, Ye YQ, Zhu Y, Grossman HB, Wu XF. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res, 2008, 68(7): 2530-2537.
[12] Ye YQ, Wang KK, Gu J, Yang HS, Lin J, Ajani JA, Wu XF. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. Cancer Prev Res (Phila Pa), 2008, 1(6): 460-469.
[13] Clague J, Lippman SM, Yang H, Hildebrandt MA, Ye Y, Lee JJ, Wu X. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. Mol Carcinog, 2010, 49(2): 183-189.
[14] Duan RH, Pak CH, Jin P. Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet, 2007, 16(9): 1124-1131.
[15] Adams BD, Furneaux H, White BA. The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-α (ERα) and represses ERα messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol, 2007, 21(5): 1132-1147.
[16] Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A. Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA, 2008, 105(20): 7269-7274.
[17] Jazdzewski K, Liyanarachchi S, Swierniak M, Pachucki J, Ringel MD, Jarzab B, de la Chapelle A. Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. Proc Natl Acad Sci USA, 2009, 106(5): 1502-1505.
[18] Xu B, Feng NH, Li PC, Tao J, Wu D, Zhang ZD, Tong N, Wang JF, Song NH, Zhang W, Hua LX, Wu HF. A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. Prostate, 2010, 70(5): 467-472.
[19] Xu T, Zhu Y, Zhu Y, Wei QK, Yuan YF, Zhou F, Ge YY, Yang JR, Su H, Zhuang SM. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis, 2008, 29(1

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Association of human microRNA related genetic variations with cancer

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Qingyu Sun, Yang Zhou, Lijuan Du, Mengke Zhang, Jiale Wang, Yuanyuan Ren, Fang Liu. Analysis between macrophage-related genes with prognosis and tumor microenvironment in non-small cell lung cancer [J]. Hereditas(Beijing), 2023, 45(8): 684-699.
[2]	Weize Kong, Yishi Liu, Xiaodong Gao, Morihisa Fujita. Comprehensive in silico analysis of glycosylphosphatidylinositol- anchored protein (GPI-AP) related genes expression profiles in human normal and cancer tissues [J]. Hereditas(Beijing), 2023, 45(8): 669-683.
[3]	Dantong Xu, Yifei Wang, Jiali Cai, Wentao Gong, Xiangchun Pan, Yuhan Tian, Qingpeng Shen, Jiaqi Li, Xiaolong Yuan. Study on detection of CNVs using human whole genome bisulfite sequencing data [J]. Hereditas(Beijing), 2023, 45(4): 324-340.
[4]	Chunhui Ma, Haixu Hu, Lijuan Zhang, Yi Liu, Tianyi Liu. Establishment and verification of a digital PCR assay for the detection of CK19 expression in quantitative analysis of circulating tumor cell [J]. Hereditas(Beijing), 2023, 45(3): 250-260.
[5]	Dong Chang, Xiangxiang Liu, Rui Liu, Jianwei Sun. The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression [J]. Hereditas(Beijing), 2023, 45(2): 115-127.
[6]	Fengyu Sun, Qianghua Xu. Research progress of microRNAs involved in hematopoiesis [J]. Hereditas(Beijing), 2022, 44(9): 756-771.
[7]	Sihan Qi, Qilin Wang, Junyou Zhang, Qian Liu, Chunyan Li. The regulatory mechanisms by enhancers during cancer initiation and progression [J]. Hereditas(Beijing), 2022, 44(4): 275-288.
[8]	Xueqian Wang, Qingzhen Zhang, Peng Cheng, Tingting Dong, Weiguo Li, Zhe Zhou, Shengqi Wang. Genetic polymorphisms of 66 InDel loci in the Chinese Han population [J]. Hereditas(Beijing), 2022, 44(4): 335-345.
[9]	Changgui Lei, Xueyuan Jia, Wenjing Sun. Establish six-gene prognostic model for glioblastoma based on multi-omics data of TCGA database [J]. Hereditas(Beijing), 2021, 43(7): 665-679.
[10]	Youhong Chen, Wenhao Yang, Chao Ni. Using esophagus organoid to explore the role of c-Myc in esophageal cancer initiation [J]. Hereditas(Beijing), 2021, 43(6): 601-614.
[11]	Yige Li, Dandan Zhang. Progress on functional mechanisms of colorectal cancer causal SNPs in post-GWAS [J]. Hereditas(Beijing), 2021, 43(3): 203-214.
[12]	Yanyan Cao, Miaomiao Cheng, Fang Song, Yujin Qu, Jinli Bai, Hong Wang. Familial study of spinal muscular atrophy carriers with SMN1 (2+0) genotype [J]. Hereditas(Beijing), 2021, 43(2): 160-168.
[13]	Enquan Zhang, Weicong Cai, Guiling Li, Jian Li, Jingwen Liu. Analysis of microRNA expression profile in Emiliania huxleyi in response to virus infection [J]. Hereditas(Beijing), 2021, 43(11): 1088-1100.
[14]	Haoyu Wang, Yuhan Hu, Yueyan Cao, Qiang Zhu, Yuguo Huang, Xi Li, Ji Zhang. AI-SNPs screening based on the whole genome data and research on genetic structure differences of subcontinent populations [J]. Hereditas(Beijing), 2021, 43(10): 938-948.
[15]	Yajie Wang, Shuangshuang Wu, Jiang Chu, Xiangyang Kong. Lung microbiome mediates the progression from chronic obstructive pulmonary disease to lung cancer through inflammation [J]. Hereditas(Beijing), 2021, 43(1): 30-39.