精子尾部发育相关蛋白研究进展

doi:10.16288/j.yczz.19-309

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Hereditas(Beijing) ›› 2020, Vol. 42 ›› Issue (6): 524-535.doi: 10.16288/j.yczz.19-309

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Research progress of proteins related to sperm tail development

Yanan Zhong, Changmin Niu, Mengmeng Xia, Ying Zheng

Department of Histology and Embryology, School of Medicine, Yangzhou University, Yangzhou 225001, China

Received:2019-12-25 Revised:2020-04-02 Online:2020-06-20 Published:2020-05-07
Supported by:
Supported by the National Natural Science Foundation of China No(81871205);the Natural Science Foundation of Jiangsu Province No(BK20131230)

Abstract

Abstract:

The structure of sperm tail is closely related to its motor function, which directly determines whether the sperm can be normally transported to fallopian tube and fertilize the ovum. The formation and development of sperm tail is a very complex process, which is finely regulated by various kinds of proteins. Research finds that defects of various sperm tail development related proteins can lead to oligospermia, asthenozoospermia and teratospermia. Based on the ultrastructure of sperm tail, we summarize the recent research progress of the proteins related to sperm tail development, thereby providing the theoretical basis and practical possibility for the diagnosis and treatment of male infertility.

Key words: sperm tail, development, protein, research progress

Yanan Zhong, Changmin Niu, Mengmeng Xia, Ying Zheng. Research progress of proteins related to sperm tail development[J]. Hereditas(Beijing), 2020, 42(6): 524-535.

Figures/Tables 2

References 57

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精子尾部结构	发育相关蛋白
植入窝和基底板	SUN5和OAZ3
小头和节柱	SPATA6
中心体	SPATC1L、CEP135、CFAP43和CFAP44
Manchette	STK33、KIF3A、LRGUK1、SEPT12和MEIG1
轴丝	CFAP69、SPEF2、ARMC2、TCTE1、RSPH6A、DNAH1、DNAH2、C11orf70和PIH1D3
外周致密纤维	ODF1、ODF2、ODF3、Tssk4和MNS1
线粒体鞘	KLC3、MFN2和CFAP251
纤维鞘	FSIP2、AKAP4、AKAP3、ROPN1、ROPN1L、FS39、Als2cr12、Mtsga10、ENO4和CFAP157

Research progress of proteins related to sperm tail development

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