遗传 ›› 2015, Vol. 37 ›› Issue (2): 111-120.doi: 10.16288/j.yczz.14-283
• 综述 • 下一篇
曹丽娟,刘昕訸,查晴,宋倩,杨克,刘艳
收稿日期:2014-08-26
出版日期:2015-02-20
发布日期:2015-01-19
通讯作者:
刘艳,博士,主任医师,硕士生导师,研究方向：动脉粥样硬化。E-mail：liuyan_ivy@126.com
作者简介:曹丽娟,硕士研究生,专业方向：动脉粥样硬化。Tel：021-64370045;E-mail：caolijuanqq@163.com
基金资助:Lijuan Cao,Xinhe Liu,Qing Zha,Qian Song,Ke Yang,Yan Liu
Received:2014-08-26
Online:2015-02-20
Published:2015-01-19
摘要： 蛋白去乙酰化酶在细胞生理过程中发挥着极为重要的作用。人蛋白去乙酰化酶包括HDACⅠ、HDACⅡ、HDACⅢ和HDACⅣ4个家族。其中第Ⅲ类即Sir2(Silent information regulator 2)家族包括7个成员——SIRT1~ SIRT7,每个成员都具有不同的细胞定位,并且发挥不同的生物学功能。作为主要定位于线粒体的组蛋白去乙酰化酶,SIRT3不仅调节细胞的能量代谢,并在细胞凋亡、肿瘤生长和一些疾病中发挥作用。文章综述了SIRT3在细胞代谢中的生物学功能以及其在心血管疾病中的研究进展。
曹丽娟,刘昕訸,查晴,宋倩,杨克,刘艳. SIRT3与细胞代谢及心血管疾病的相关性[J]. 遗传, 2015, 37(2): 111-120.
Lijuan Cao,Xinhe Liu,Qing Zha,Qian Song,Ke Yang,Yan Liu. The relationship of SIRT3 with cellular metabolism and cardiovascular diseases[J]. HEREDITAS(Beijing), 2015, 37(2): 111-120.
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