遗传 ›› 2016, Vol. 38 ›› Issue (10): 881-893.doi: 10.16288/j.yczz.16-141
陈昱帆1, 2, 刘诗胤1, 2, 梁志彬1, 2, 吕明发1, 2, 周佳暖1, 2, 张炼辉1, 2
收稿日期:2016-04-20
修回日期:2016-06-20
出版日期:2016-10-20
发布日期:2016-10-20
作者简介:张炼辉,博士,教授,博士生导师,研究方向：微生物学、植物病理学。
基金资助:Yufan Chen1, 2, Shiyin Liu1, 2, Zhibin Liang1, 2, Mingfa Lv1, 2, Jianuan Zhou1, 2, Lianhui Zhang1, 2
Received:2016-04-20
Revised:2016-06-20
Online:2016-10-20
Published:2016-10-20
Supported by:摘要： 微生物耐药性已成为全球关注的严重问题,其演化机制和调控机理也已成为研究热点。近年来的研究发现,一些微生物耐药性机制受到群体感应系统的调控。群体感应是一种在微生物界广泛存在并与菌体密度关联的细胞-细胞间的通讯系统。高密度的菌落群体能够产生足够数量的小分子信号,激活下游包括致病毒力和耐药性机制在内的多种细胞进程,耐受抗生素并且危害寄主。本文结合国内外最新的研究进展,对微生物群体感应系统的研究现状进行了概括性介绍,重点阐述了群体感应系统对微生物耐药性机制的调控作用,如微生物生物被膜形成和药物外排泵调控等方面的作用,并探讨了利用群体淬灭控制微生物耐药性的新策略。
陈昱帆, 刘诗胤, 梁志彬, 吕明发, 周佳暖, 张炼辉. 群体感应与微生物耐药性[J]. 遗传, 2016, 38(10): 881-893.
Yufan Chen, Shiyin Liu, Zhibin Liang, Mingfa Lv, Jianuan Zhou, Lianhui Zhang. Quorum sensing and microbial drug resistance[J]. Hereditas(Beijing), 2016, 38(10): 881-893.
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| [1] | 梁志彬, 陈豫梅, 陈昱帆, 程莹莹, 张炼辉. RND家族外排泵及其与微生物群体感应系统的相互关系[J]. 遗传, 2016, 38(10): 894-901. |
| [2] | 陈林，杨亮，段康民. 从进化谈细菌细胞间的群体感应信号传递[J]. 遗传, 2012, 34(1): 33-40. |
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