[1] Blair JMA, Webber MA, Baylay AJ, Ogbolu DO, Piddock LJV. Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol , 2015, 13(1): 42-51. [2] Li XZ, Plésiat P, Nikaido H. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev , 2015, 28(2): 337-418. [3] Blair JMA, Piddock LJV. Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update. Curr Opin Microbiol , 2009, 12(5): 512-519. [4] Roggiani M, Dubnau D. ComA, a phosphorylated response regulator protein of Bacillus subtilis , binds to the promoter region of srfA . J Bacteriol , 1993, 175(10): 3182-3187. [5] Eberl L, Winson MK, Sternberg C, Stewart GSAB, Christiansen G, Chhabra SR, Bycroft B, Williams P, Molin S, Givskov M. Involvement of N -acyl-L-homoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens . Mol Microbiol , 1996, 20(1): 127-136. [6] Marketon MM, Glenn SA, Eberhard A, González JE. Quorum sensing controls exopolysaccharide production in Sinorhizobium meliloti . J Bacteriol , 2003, 185(1): 325-331. [7] Deng YY, Schmid N, Wang C, Wang JH, Pessi G, Wu DH, Lee J, Aguilar C, Ahrens CH, Chang CQ, Song HW, Eberl L, Zhang LH. Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover. Proc Natl Acad Sci USA , 2012, 109(38): 15479-15484. [8] Zhang LH, Murphy PJ, Kerr A, Tate ME. Agrobacterium conjugation and gene regulation by N -acyl-L-homoserine lactones. Nature , 1993, 362(6419): 446-448. [9] Davies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science , 1998, 280(5361): 295-298. [10] Daury L, Orange F, Taveau JC, Verchère A, Monlezun L, Gounou C, Marreddy RKR, Picard M, Broutin I, Pos KM, Lambert O. Tripartite assembly of RND multidrug efflux pumps. Nat Commun , 2016, 7: 10731. [11] Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature , 2006, 443(7108): 173-179. [12] Husain F, Bikhchandani M, Nikaido H. Vestibules are part of the substrate path in the multidrug efflux transporter AcrB of Escherichia coli . J Bacteriol , 2011, 193(20): 5847-5849. [13] Anes J, McCusker MP, Fanning S, Martins M. The ins and outs of RND efflux pumps in Escherichia coli . Front Microbiol , 2015, 6: 587. [14] Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T. Contribution of the MexX-MexY-OprM efflux system to intrinsic resistance in Pseudomonas aeruginosa . Antimicrob Agents Chemother , 2000, 44(9): 2242-2246. [15] Mine T, Morita Y, Kataoka A, Mizushima T, Tsuchiya T. Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa . Antimicrob Agents Chemother , 1999, 43(2): 415-417. [16] Poole K, Krebes K, McNally C, Neshat S. Multiple antibiotic resistance in Pseudomonas aeruginosa : evidence for involvement of an efflux operon. J Bacteriol , 1993, 175(22): 7363-7372. [17] Koronakis V, Sharff A, Koronakis E, Luisi B, Hughes C. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature , 2000, 405(6789): 914-919. [18] Dreier J, Ruggerone P. Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa . Front Microbiol , 2015, 6: 660. [19] Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa : clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev , 2009, 22(4): 582-610. [20] Buroni S, Matthijs N, Spadaro F, Van Acker H, Scoffone VC, Pasca MR, Riccardi G, Coenye T. Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and plankton |