遗传 ›› 2017, Vol. 39 ›› Issue (10): 897-907.doi: 10.16288/j.yczz.17-037

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Wnt信号通路在毛细胞分化和再生过程中的作用

范晴晴(),孟飞龙,房冉,李高鹏,赵小立()   

  1. 浙江大学生命科学学院遗传与再生生物学研究所,浙江省细胞与基因工程重点研究实验室,杭州 310058
  • 收稿日期:2017-02-08 修回日期:2017-04-03 出版日期:2017-10-20 发布日期:2017-09-19
  • 作者简介:范晴晴,硕士研究生,专业方向：干细胞分化。E-mail: 21407051@zju.edu.cn|赵小立，副教授，硕士生导师，研究方向：干细胞分化。E-mail: zhaoxiaoli@zju.edu.cn
  • 基金资助:
    国家重点基础研究发展规划(973计划)(2012CB967900)

Functions of Wnt signaling pathway in hair cell differentiation and regeneration

Qingqing Fan(),Feilong Meng,Ran Fang,Gaopeng Li,Xiaoli Zhao()   

  1. Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Institute of Genetics and Regenerative Biology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China
  • Received:2017-02-08 Revised:2017-04-03 Online:2017-10-20 Published:2017-09-19
  • Supported by:
    the National Program on Key Basic Research Project (973 Program)(2012CB967900)

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摘要：

Wnt信号通路在生物发育和维持内环境稳态过程中起着重要作用。Wnt配体通过与Frizzle受体结合参与体轴的形成、细胞分化和细胞命运决定等生命活动。在小鼠内耳发育过程中,Wnt信号通路扮演了重要角色：在内耳发育早期阶段,参与听基板的特化和听泡的形成;在内耳发育后期阶段,调控毛细胞分化及毛细胞纤毛束的定向。本文综述了Wnt信号通路在内耳毛细胞发育分化及再生过程中的研究进展,以期为从事相关领域的科研人员提供参考。

关键词: Wnt信号通路, 听基板, 听泡, 毛细胞再生

Abstract:

Wnt signaling pathway plays important roles in the development and homeostasis of multicellular organisms. Through their bindings with the Frizzled receptors, the Wnt ligands regulate a wide range of developmental processes, such as axis patterning, cell division, and cell fate specification. Wnt signaling plays vital roles in the development of inner ear of the mouse. In the early stages of inner ear development, Wnt signaling specifies the size of the placode and the formation of the otic vesicle. In later stages, Wnt signaling mediates hair cell specification and orients the stereociliary bundles in a uniform direction. In this review, we summarize the current knowledge on the roles of Wnt signaling in hair cell differentiation and regeneration, which may provide references and insights for investigators in the field.

Key words: Wnt signaling pathway, otic placode, otic vesicle, hair cell regeneration