PPR蛋白在植物细胞器组分转录后调控中的作用机制

doi:10.16288/j.yczz.21-233

遗传 ›› 2021, Vol. 43 ›› Issue (11): 1050-1065.doi: 10.16288/j.yczz.21-233

PPR蛋白在植物细胞器组分转录后调控中的作用机制

郝媛媛(), 赵向前, 黄福灯, 李春寿()

浙江省农业科学院作物与核技术利用研究所,杭州 310021

收稿日期:2021-06-30 修回日期:2021-08-20 出版日期:2021-11-20 发布日期:2021-10-25
通讯作者: 李春寿 E-mail:499085663@qq.com;lichunshou@126.com
作者简介:郝媛媛,博士,助理研究员,研究方向：稻米品质的改良和分子机理。E-mail: 499085663@qq.com
基金资助:
国家自然科学基金项目编号资助(32001524)

The role of PPR proteins in posttranscriptional regulation of organelle components in plants

Yuanyuan Hao(), Xiangqian Zhao, Fudeng Huang, Chunshou Li()

Institute of Crop and Nuclear Technology Utilization, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China

Received:2021-06-30 Revised:2021-08-20 Online:2021-11-20 Published:2021-10-25
Contact: Li Chunshou E-mail:499085663@qq.com;lichunshou@126.com
Supported by:
Supported by the National Natural Science Foundation of China No(32001524)

摘要/Abstract

摘要：

PPR (pentatricopeptide repeats)蛋白是陆生植物中最大的蛋白家族之一,是一类RNA结合蛋白,参与细胞器基因的转录后加工过程,对细胞器的生物合成和功能具有深远影响。PPR突变后造成叶绿体光合电子传递链和线粒体呼吸链等进程受损,最终通过影响光合作用或者呼吸作用,造成植株生长发育异常,影响产量、育性、籽粒品质等。近年来,关于该蛋白家族成员参与植物生长发育的报道越来越多,但由于该家族庞大,大部分成员的功能还未被解析。本文系统总结了目前PPR蛋白调控细胞器基因转录后加工的分子机理及对细胞器和植株发育的影响,提出PPR家族还未解决的问题,为深入解析该基因家族的功能及育种应用提供理论基础。

关键词: PPR蛋白, 转录后调控, 细胞器代谢, 植株生长发育

Abstract:

Pentatricopeptide repeat (PPR) proteins constitute one of the largest protein families in land plants. They are sequence-specific RNA-binding proteins and play key roles in posttranscriptional processes within organelles. Their combined actions have profound effects on chloroplast photosynthetic electron transport chain and mitochondrial respiratory chain, affecting photosynthesis and respiration respectively, and ultimately on yield, fertility, and grain quality. Over the past decade, much has been learned about the molecular functions of these proteins on plant growth and development. However, due to the large size of this protein family, the functions of most members remain largely unknown. Here, we summarize the molecular mechanisms of PPR proteins functions on organelle genes, and effects on development of organelles and plants. Problems that need to be resolved are also identified. This article will provide a theoretical basis for understanding the functions of PPR protein family and genetic improvements of grain yield and quality.

Key words: PPR proteins, post-transcriptional regulation, organelle metabolism, plant growth and development

郝媛媛, 赵向前, 黄福灯, 李春寿. PPR蛋白在植物细胞器组分转录后调控中的作用机制[J]. 遗传, 2021, 43(11): 1050-1065.

Yuanyuan Hao, Xiangqian Zhao, Fudeng Huang, Chunshou Li. The role of PPR proteins in posttranscriptional regulation of organelle components in plants[J]. Hereditas(Beijing), 2021, 43(11): 1050-1065.

图/表 4

图1

图2

图3

表1

参考文献 126

[1]	Manthey GM, Mcewen JE. The product of the nuclear genePET309 is required for translation of mature mRNA and stability or production of intron-containing RNAs derived from the mitochondrial COX1 locus of Saccharomyces cerevisiae. EMBO J, 1995, 14(16):4031-4043. pmid: 7664742
[2]	Coffin JW, Dhillon R, Ritzel RG, Nargang FE. TheNeurospora crassa cya-5 nuclear gene encodes a protein with a region of homology to the Saccharomyces cerevisiae PET309 protein and is required in a post-transcriptional step for the expression of the mitochondrially encoded COXI protein. Curr Genet, 1997, 32(4):273-280. pmid: 9342407
[3]	Lurin C, Andrés C, Aubourg S, Bellaoui M, Bitton F, Bruyere C, Caboche M, Debast C, Gualberto J, Hoffmann B, Lecharny A, Le Ret M, Martin-Magniette ML, Mireau H, Peeters N, Renou JP, Szurek B, Taconnat L, Small I. Genome-wide analysis ofArabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis. Plant Cell, 2004, 16(8):2089-2103. doi: 10.1105/tpc.104.022236
[4]	Bonen L. Cis- and trans-splicing of group II introns in plant mitochondria. Mitochondrion, 2008, 8(1):26-34. doi: 10.1016/j.mito.2007.09.005
[5]	Brown GG, des Francs-Small CC, Ostersetzer-Biran O. Group II intron splicing factors in plant mitochondria. Front Plant Sci, 2014, 5:35.
[6]	Huang WH, Zhu YJ, Wu WJ, Li X, Zhang DL, Yin P, Huang JR. The pentatricopeptide repeat protein SOT5/ EMB2279 is required for plastidrpl2 and trnK intron splicing. Plant Physiol, 2018, 177(2):684-697. doi: 10.1104/pp.18.00406
[7]	De Longevialle AF, Meyer EH, Andrés C, Taylor NL, Lurin C, Millar AH, Small ID. The pentatricopeptide repeat geneOTP43 is required for trans-splicing of the mitochondrial nad1 intron 1 in Arabidopsis thaliana. Plant Cell, 2007, 19(10):3256-3265. pmid: 17965268
[8]	Wu MM, Ren YL, Cai MH, Wang YL, Zhu SS, Zhu JP, Hao YY, Teng X, Zhu XP, Jing RN, Zhang H, Zhong MS, Wang YF, Lei CL, Zhang X, Guo XP, Cheng ZJ, Lin QB, Wang J, Jiang L, Bao YQ, Wang YH, Wan JM. RiceFLOURY ENDOSPERM10 encodes a pentatricopeptide repeat protein that is essential for the trans- splicing of mitochondrial nad1 intron 1 and endosperm development. New Phytol, 2019, 223(2):736-750. doi: 10.1111/nph.2019.223.issue-2
[9]	Ren XM, Pan ZY, Zhao HL, Zhao JL, Cai MJ, Li J, Zhang ZX, Qiu FZ. EMPTY PERICARP11 serves as a factor for splicing of mitochondrialnad1 intron and is required to ensure proper seed development in maize. J Exp Bot, 2017, 68(16):4571-4581. doi: 10.1093/jxb/erx212
[10]	Qi WW, Yang Y, Feng XZ, Zhang ML, Song RT. Mitochondrial function and maize kernel development requires Dek2, a pentatricopeptide repeat protein involved innad1 mRNA splicing. Genetics, 2017, 205(1):239-249. doi: 10.1534/genetics.116.196105
[11]	Sun Y, Huang JY, Zhong S, Gu HY, He S, Qu LJ. Novel DYW-type pentatricopeptide repeat (PPR) protein BLX controls mitochondrial RNA editing and splicing essential for early seed development of Arabidopsis. J Genet Genomics, 2018, 45(3):155-168. doi: 10.1016/j.jgg.2018.01.006
[12]	Sun F, Zhang XY, Shen Y, Wang HC, Liu R, Wang XM, Gao DH, Yang YZ, Liu YW, Tan BC. The pentatricopeptide repeat protein EMPTY PERICARP8 is required for the splicing of three mitochondrial introns and seed development in maize. Plant J, 2018, 95(5):919-932. doi: 10.1111/tpj.2018.95.issue-5
[13]	Sun F, Xiu ZH, Jiang RC, Liu YW, Zhang XY, Yang YZ, Li XJ, Zhang X, Wang Y, Tan BC. The mitochondrial pentatricopeptide repeat protein EMP12 is involved in the splicing of threenad2 introns and seed development in maize. J Exp Bot, 2019, 70(3):963-972. doi: 10.1093/jxb/ery432
[14]	Dai DW, Luan SC, Chen XZ, Wang Q, Feng Y, Zhu CG, Qi WW, Song RT. Maize Dek37 encodes a P-type PPR protein that affectscis-splicing of mitochondrial nad2 intron 1 and seed development. Genetics, 2018, 208(3):1069-1082. doi: 10.1534/genetics.117.300602
[15]	Cai MJ, Li SZ, Sun F, Sun Q, Zhao HL, Ren XM, Zhao YX, Tan BC, Zhang ZX, Qiu FZ. Emp10 encodes a mitochondrial PPR protein that affects the cis-splicing of nad2 intron 1 and seed development in maize. Plant J, 2017, 91(1):132-144. doi: 10.1111/tpj.2017.91.issue-1
[16]	Zhao P, Wang F, Li N, Shi DQ, Yang WC. Pentatricopeptide repeat protein MID1 modulates nad2 intron 1 splicing and Arabidopsis development. Sci Rep, 2020, 10(1):2008. doi: 10.1038/s41598-020-58495-5
[17]	Weissenberger S, Soll J, Carrie C. The PPR protein SLOW GROWTH 4 is involved in editing of nad4 and affects the splicing of nad2 intron 1. Plant Mol Biol, 2017, 93(4-5):355-368. doi: 10.1007/s11103-016-0566-4
[18]	Liu Y, He JN, Chen ZZ, Ren XZ, Hong XH, Gong ZZ. ABA overly-sensitive 5 (ABO5), encoding a pentatricopeptide repeat protein required for cis-splicing of mitochondrial nad2 intron 3, is involved in the abscisic acid response in Arabidopsis. Plant J, 2010, 63(5):749-765. doi: 10.1111/tpj.2010.63.issue-5
[19]	Yang YZ, Ding S, Wang Y, Wang HC, Liu XY, Sun F, Xu CH, Liu BH, Tan BC. PPR20 is required for the cis-splicing of mitochondrial nad2 intron 3 and seed development in maize. Plant Cell Physiol, 2020, 61(2):370-380. doi: 10.1093/pcp/pcz204 pmid: 31670803
[20]	Wang CD, Aubé F, Quadrado M, Dargel-Graffin C, Mireau H. Three new pentatricopeptide repeat proteins facilitate the splicing of mitochondrial transcripts and complex I biogenesis in Arabidopsis. J Exp Bot, 2018, 69(21):5131-5140. doi: 10.1093/jxb/ery275
[21]	Xiu ZH, Sun F, Shen Y, Zhang XY, Jiang RC, Bonnard G, Zhang JH, Tan BC. EMPTY PERICARP16 is required for mitochondrial nad2 intron 4 cis-splicing, complex I assembly and seed development in maize. Plant J, 2016, 85(4):507-519. doi: 10.1111/tpj.13122
[22]	Ren ZJ, Fan KJ, Fang T, Zhang JJ, Yang L, Wang JH, Wang GY, Liu YJ. Maizeempty pericarp602 encodes a P-type PPR protein that is essential for seed development. Plant Cell Physiol, 2019, 60(8):1734-1746. doi: 10.1093/pcp/pcz083
[23]	Ren RC, Wang LL, Zhang L, Zhao YJ, Wu JW, Wei YM, Zhang XS, Zhao XY. DEK43 is a P-type pentatricopeptide repeat (PPR) protein responsible for the cis-splicing of nad4 in maize mitochondria. J Integr Plant Biol, 2020, 62(3):299-313. doi: 10.1111/jipb.v62.3
[24]	Chen XZ, Feng F, Qi WW, Xu LM, Yao DS, Wang Q, Song RT. Dek35 encodes a PPR protein that affectscis-splicing of mitochondrial nad4 intron 1 and seed development in maize. Mol Plant, 2017, 10(3):427-441. doi: 10.1016/j.molp.2016.08.008
[25]	Pan ZY, Liu M, Xiao ZY, Ren XM, Zhao HL, Gong DM, Liang K, Tan ZD, Shao YQ, Qiu FZ. ZmSMK9, a pentatricopeptide repeat protein, is involved in the cis-splicing of nad5, kernel development and plant architecture in maize. Plant Sci, 2019, 288:110205. doi: 10.1016/j.plantsci.2019.110205
[26]	Des Francs-Small CC, De Longevialle AF, Li YH, Lowe E, Tanz SK, Smith C, Bevan MW, Small I. The pentatricopeptide repeat proteins TANG2 and ORGANELLE TRANSCRIPT PROCESSING439 are involved in the splicing of the multipartitenad5 transcript encoding a subunit of mitochondrial complex I. Plant Physiol, 2014, 165(4):1409-1416. pmid: 24958715
[27]	Koprivova A, Des Francs-Small CC, Calder G, Mugford ST, Tanz S, Lee BR, Zechmann B, Small I, Kopriva S. Identification of a pentatricopeptide repeat protein implicated in splicing of intron 1 of mitochondrialnad7 transcripts. J Biol Chem, 2010, 285(42):32192-32199. doi: 10.1074/jbc.M110.147603 pmid: 20682769
[28]	Haïli N, Planchard N, Arnal N, Quadrado M, Vrielynck N, Dahan J, Des Francs-Small CC, Mireau H. The MTL1 pentatricopeptide repeat protein is required for both translation and splicing of the mitochondrialNADH DEHYDROGENASE SUBUNIT7 mRNA in Arabidopsis. Plant Physiol, 2016, 170(1):354-366. doi: 10.1104/pp.15.01591
[29]	De Longevialle AF, Small ID, Lurin C. Nuclearly encoded splicing factors implicated in RNA splicing in higher plant organelles. Mol Plant, 2010, 3(4):691-705. doi: 10.1093/mp/ssq025 pmid: 20603383
[30]	PYLE AM. Group II Intron Self-Splicing. Annu Rev Biophys, 2016, 45(1):183-205. doi: 10.1146/biophys.2016.45.issue-1
[31]	MICHEL F, UMESONO K, OZEKI H. Comparative and functional anatomy of group II catalytic introns—a review. Gene, 1989, 82(1):5-30. doi: 10.1016/0378-1119(89)90026-7
[32]	Wang Y, Ren YL, Zhou KN, Liu LL, Wang JJ, Xu Y, Zhang H, Zhang L, Feng ZM, Wang LW, Ma WW, Wang YL, Guo XP, Zhang X, Lei CL, Cheng ZJ, Wan JM. WHITE STRIPE LEAF4 encodes a novel P-type PPR protein required for chloroplast biogenesis during early leaf development. Front Plant Sci, 2017, 8:1116. doi: 10.3389/fpls.2017.01116
[33]	Beick S, Schmitz-Linneweber C, Williams-Carrier R, Jensen B, Barkan A. The pentatricopeptide repeat protein PPR5 stabilizes a specific tRNA precursor in maize chloroplasts. Mol Cell Biol, 2008, 28(17):5337-5347. doi: 10.1128/MCB.00563-08
[34]	Wang XM, Yang ZP, Zhang Y, Zhou W, Zhang AH, Lu CM. Pentatricopeptide repeat protein PHOTOSYSTEM I BIOGENESIS FACTOR2 is required for splicing ofycf3. J Integr Plant Biol, 2020, 62(11):1741-1761. doi: 10.1111/jipb.v62.11
[35]	Khrouchtchova A, Monde RA, Barkan A. A short PPR protein required for the splicing of specific group II introns in angiosperm chloroplasts. RNA, 2012, 18(6):1197-1209. doi: 10.1261/rna.032623.112 pmid: 22495966
[36]	de Longevialle AF, Hendrickson L, Taylor NL, Delannoy E, Lurin C, Badger M, Millar AH, Small I. The pentatricopeptide repeat gene OTP51 with two LAGLIDADG motifs is required for thecis-splicing of plastid ycf3 intron 2 in Arabidopsis thaliana. Plant J, 2008, 56(1):157-168. doi: 10.1111/tpj.2008.56.issue-1
[37]	Chateigner-Boutin AL, Des Francs-Small CC, Delannoy E, Kahlau S, Tanz SK, De Longevialle AF, Fujii S, Small I. OTP70 is a pentatricopeptide repeat protein of the E subgroup involved in splicing of the plastid transcriptrpoC1. Plant J, 2011, 65(4):532-542. doi: 10.1111/tpj.2011.65.issue-4
[38]	Schmitz-Linneweber C, Williams-Carrier RE, Williams- Voelker PM, Kroeger TS, Vichas A, Barkan A. A pentatricopeptide repeat protein facilitates the trans-splicing of the maize chloroplast rps12 pre-mRNA. Plant Cell, 2006, 18(10):2650-2663. pmid: 17041147
[39]	Aryamanesh N, Ruwe H, Sanglard LVP, Eshraghi L, Bussell JD, Howell KA, Small I, Des Francs-Small CC. The pentatricopeptide repeat protein EMB2654 Is essential fortrans-splicing of a chloroplast small ribosomal subunit transcript. Plant Physiol, 2017, 173(2):1164-1176. doi: 10.1104/pp.16.01840 pmid: 28011633
[40]	Lee K, Park SJ, des Francs-Small CC, Whitby M, Small I, Kang H. The coordinated action of PPR4 and EMB2654 on each intron half mediates trans-splicing of rps12 transcripts in plant chloroplasts. Plant J, 2019, 100(6):1193-1207. doi: 10.1111/tpj.v100.6
[41]	Liu X, Lan J, Huang YS, Cao PH, Zhou CL, Ren YK, He NQ, Liu SJ, Tian YL, Nguyen T, Jiang L, Wan JM. Corrigendum: WSL5, a pentatricopeptide repeat protein, is essential for chloroplast biogenesis in rice under cold stress. J Exp Bot, 2018, 69(18):4495. doi: 10.1093/jxb/ery259 pmid: 30011040
[42]	Tan JJ, Tan ZH, Wu FQ, Sheng PK, Heng YQ, Wang XH, Ren YL, Wang JL, Guo XP, Zhang X, Cheng ZJ, Jiang L, Liu XM, Wang HY, Wan JM. A novel chloroplast-localized pentatricopeptide repeat protein involved in splicing affects chloroplast development and abiotic stress response in rice. Mol Plant, 2014, 7(8):1329-1349. doi: 10.1093/mp/ssu054
[43]	Barkan A, Small I. Pentatricopeptide repeat proteins in plants. Annu Rev Plant Biol, 2014, 65:415-442. doi: 10.1146/annurev-arplant-050213-040159 pmid: 24471833
[44]	Pfalz J, Bayraktar OA, Prikryl J, Barkan A. Site-specific binding of a PPR protein defines and stabilizes 5' and 3' mRNA termini in chloroplasts. EMBO J, 2009, 28(14):2042-2052. doi: 10.1038/emboj.2009.121
[45]	Barkan A, Walker M, Nolasco M, Johnson D. A nuclear mutation in maize blocks the processing and translation of several chloroplast mRNAs and provides evidence for the differential translation of alternative mRNA forms. EMBO J, 1994, 13(13):3170-3181. pmid: 8039510
[46]	Meierhoff K, Felder S, Nakamura T, Bechtold N, Schuster G. HCF152, an Arabidopsis RNA binding pentatricopeptide repeat protein involved in the processing of chloroplast psbB-psbT-psbH-petB-petD RNAs. Plant Cell, 2003, 15(6):1480-1495. pmid: 12782738
[47]	Zoschke R, Kroeger T, Belcher S, Schöttler MA, Barkan A, Schmitz-Linneweber C. The pentatricopeptide repeat-SMR protein ATP4 promotes translation of the chloroplastatpB/E mRNA. Plant J, 2012, 72(4):547-558. doi: 10.1111/tpj.2012.72.issue-4
[48]	Johnson X, Wostrikoff K, Finazzi G, Kuras R, Schwarz C, Bujaldon S, Nickelsen J, Stern DB, Wollman FA, Vallon O. MRL1, a conserved pentatricopeptide repeat protein, is required for stabilization ofrbcL mRNA in Chlamydomonas and Arabidopsis. Plant Cell, 2010, 22(1):234-248. doi: 10.1105/tpc.109.066266
[49]	Cai WH, Okuda K, Peng LW, Shikanai T. PROTON GRADIENT REGULATION 3 recognizes multiple targets with limited similarity and mediates translation and RNA stabilization in plastids. Plant J, 2011, 67(2):318-327. doi: 10.1111/tpj.2011.67.issue-2
[50]	Hammani K, Takenaka M, Miranda R, Barkan A. A PPR protein in the PLS subfamily stabilizes the 5'-end of processedrpl16 mRNAs in maize chloroplasts. Nucleic Acids Res, 2016, 44(9):4278-4288. doi: 10.1093/nar/gkw270 pmid: 27095196
[51]	Ruwe H, Wang GW, Gusewski S, Schmitz-Linneweber C. Systematic analysis of plant mitochondrial and chloroplast small RNAs suggests organelle-specific mRNA stabilization mechanisms. Nucleic Acids Res, 2016, 44(15):7406-7417.
[52]	Lee K, Han JH, Park YI, des Francs-Small CC, Small I, Kang H. The mitochondrial pentatricopeptide repeat protein PPR19 is involved in the stabilization ofNADH dehydrogenase 1 transcripts and is crucial for mitochondrial function and Arabidopsis thaliana development. New Phytol, 2017, 215(1):202-216. doi: 10.1111/nph.2017.215.issue-1
[53]	Wang CD, Aubé F, Planchard N, Quadrado M, Dargel- Graffin C, Nogué F, Mireau H. The pentatricopeptide repeat protein MTSF2 stabilizes anad1 precursor transcript and defines the 3' end of its 5' -half intron. Nucleic Acids Res, 2017, 45(10):6119-6134. doi: 10.1093/nar/gkx162
[54]	Haïli N, Arnal N, Quadrado M, Amiar S, Tcherkez G, Dahan J, Briozzo P, des Francs-Small CC, Vrielynck N, Mireau H. The pentatricopeptide repeat MTSF1 protein stabilizes thenad4 mRNA in Arabidopsis mitochondria. Nucleic Acids Res, 2013, 41(13):6650-6663. doi: 10.1093/nar/gkt337
[55]	Zhang YF, Suzuki M, Sun F, Tan BC. The Mitochondrion- Targeted PENTATRICOPEPTIDE REPEAT78 protein is required fornad5 mature mRNA stability and seed development in maize. Mol Plant, 2017, 10(10):1321-1333. doi: 10.1016/j.molp.2017.09.009
[56]	Zhang L, Zhou W, Che LP, Rochaix JD, Lu CM, Li WJ, Peng LW. PPR Protein BFA2 is essential for the accumulation of the atpH/F transcript in chloroplasts. Front Plant Sci, 2019, 10:446. doi: 10.3389/fpls.2019.00446 pmid: 31031784
[57]	Hanson MR, Bentolila S. Interactions of mitochondrial and nuclear genes that affect male gametophyte development. Plant Cell, 2004, 16 Suppl(Suppl):S154-S169.
[58]	Dahan J, Mireau H. The Rf and Rf-like PPR in higher plants, a fast-evolving subclass of PPR genes. RNA Biol, 2013, 10(9):1469-1476. doi: 10.4161/rna.25568
[59]	Bentolila S, Alfonso AA, Hanson MR. A pentatricopeptide repeat-containing gene restores fertility to cytoplasmic male-sterile plants. Proc Natl Acad Sci USA, 2002, 99(16):10887-10892. doi: 10.1073/pnas.102301599
[60]	Brown GG, Formanová N, Jin H, Wargachuk R, Dendy C, Patil P, Laforest M, Zhang JF, Cheung WY, Landry BS. The radish Rfo restorer gene of Ogura cytoplasmic male sterility encodes a protein with multiple pentatricopeptide repeats. Plant J, 2003, 35(2):262-272. doi: 10.1046/j.1365-313X.2003.01799.x
[61]	Klein RR, Klein PE, Mullet JE, Minx P, Rooney WL, Schertz KF. Fertility restorer locus Rf1 of sorghum(Sorghum bicolor L.) encodes a pentatricopeptide repeat protein not present in the colinear region of rice chromosome 12. Theor Appl Genet, 2005, 111(6):994-1012. pmid: 16078015
[62]	Komori T, Ohta S, Murai N, Takakura Y, Kuraya Y, Suzuki S, Hiei Y, Imaseki H, Nitta N. Map-based cloning of a fertility restorer gene,Rf-1, in rice(Oryza sativa L.). Plant J, 2004, 37(3):315-325. doi: 10.1046/j.1365-313X.2003.01961.x
[63]	Wang ZH, Zou YJ, Li XY, Zhang QY, Chen LT, Wu H, Su DH, Chen YL, Guo JX, Luo D, Long YM, Zhong Y, Liu YG. Cytoplasmic male sterility of rice with boro II cytoplasm is caused by a cytotoxic peptide and is restored by two related PPR motif genes via distinct modes of mRNA silencing. Plant Cell, 2006, 18(3):676-687. doi: 10.1105/tpc.105.038240
[64]	Hölzle A, Jonietz C, Törjek O, Altmann T, Binder S, Forner J. A RESTORER OF FERTILITY-like PPR gene is required for 5'-end processing of the nad4 mRNA in mitochondria of Arabidopsis thaliana. Plant J, 2011, 65(5):737-744. doi: 10.1111/tpj.2011.65.issue-5
[65]	Jonietz C, Forner J, Hölzle A, Thuss S, Binder S. RNA PROCESSING FACTOR2 is required for 5' end processing of nad9 and cox3 mRNAs in mitochondria of Arabidopsis thaliana. Plant Cell, 2010, 22(2):443-453. doi: 10.1105/tpc.109.066944
[66]	Jonietz C, Forner J, Hildebrandt T, Binder S. RNA PROCESSING FACTOR3 is crucial for the accumulation of mature ccmC transcripts in mitochondria of Arabidopsis accession Columbia. Plant Physiol, 2011, 157(3):1430-1439. doi: 10.1104/pp.111.181552
[67]	Hauler A, Jonietz C, Stoll B, Stoll K, Braun HP, Binder S. RNA processing factor 5 is required for efficient 5' cleavage at a processing site conserved in RNAs of three different mitochondrial genes in Arabidopsis thaliana. Plant J, 2013, 74(4):593-604. doi: 10.1111/tpj.2013.74.issue-4
[68]	Hashimoto M, Endo T, Peltier G, Tasaka M, Shikanai T. A nucleus-encoded factor, CRR2, is essential for the expression of chloroplast ndhB in Arabidopsis. Plant J, 2003, 36(4):541-549. pmid: 14617084
[69]	Okuda K, Chateigner-Boutin AL, Nakamura T, Delannoy E, Sugita M, Myouga F, Motohashi R, Shinozaki K, Small I, Shikanai T. Pentatricopeptide repeat proteins with the DYW motif have distinct molecular functions in RNA editing and RNA cleavage in Arabidopsis chloroplasts. Plant Cell, 2009, 21(1):146-156. doi: 10.1105/tpc.108.064667
[70]	Liu S, Melonek J, Boykin L M, Small I, Howell KA. PPR-SMRs: ancient proteins with enigmatic functions. RNA Biol, 2013, 10(9):1501-1510. doi: 10.4161/rna.26172
[71]	Zhou W, Lu QT, Li QW, Wang L, Ding SH, Zhang AH, Wen XG, Zhang LX, Lu CM. PPR-SMR protein SOT1 has RNA endonuclease activity. Proc Natl Acad Sci USA, 2017, 114(8):E1554-E1563. doi: 10.1073/pnas.1612460114
[72]	Zoschke R, Watkins KP, Miranda RG, Barkan A. The PPR-SMR protein PPR53 enhances the stability and translation of specific chloroplast RNAs in maize. Plant J, 2016, 85(5):594-606. doi: 10.1111/tpj.2016.85.issue-5
[73]	Hazle T, Bonen L. Comparative analysis of sequences preceding protein-coding mitochondrial genes in flowering plants. Mol Biol Evol, 2007, 24(5):1101-1112. doi: 10.1093/molbev/msm030
[74]	Manavski N, Guyon V, Meurer J, Wienand U, Brettschneider R. An essential pentatricopeptide repeat protein facilitates 5' maturation and translation initiation ofrps3 mRNA in maize mitochondria. Plant Cell, 2012, 24(7):3087-3105. doi: 10.1105/tpc.112.099051
[75]	Yan JJ, Zhang QX, Yin P. RNA editing machinery in plant organelles. Sci China Life Sci, 2018, 61(2):162-169. doi: 10.1007/s11427-017-9170-3
[76]	Walbot V. RNA editing fixes problems in plant mitochondrial transcripts. Trends Genet, 1991, 7(2):37-39. pmid: 1709762
[77]	Small ID, Schallenberg-Rudinger M, Takenaka M, Mireau H, Ostersetzer-Biran O. Plant organellar RNA editing: what 30 years of research has revealed. Plant J, 2020, 101(5):1040-1056. doi: 10.1111/tpj.14578
[78]	Corneille S, Lutz K, Maliga P. Conservation of RNA editing between rice and maize plastids: are most editing events dispensable? Mol Gen Genet, 2000, 264(4):419-424. doi: 10.1007/s004380000295
[79]	Li XJ, Zhang YF, Hou MM, Sun F, Shen Y, Xiu ZH, Wang XM, Chen ZL, Sun SSM, Small I, Tan BC. Small kernel 1 encodes a pentatricopeptide repeat protein required for mitochondrial nad7 transcript editing and seed development in maize(Zea mays) and rice (Oryza sativa). Plant J, 2014, 79(5):797-809. doi: 10.1111/tpj.2014.79.issue-5
[80]	Wang HC, Sayyed A, Liu XY, Yang YZ, Sun F, Wang Y, Wang MD, Tan BC. SMALL KERNEL4 is required for mitochondrial cox1 transcript editing and seed development in maize. J Integr Plant Biol, 2020, 62(6):777-792. doi: 10.1111/jipb.v62.6
[81]	Liu YJ, Xiu ZH, Meeley R, Tan BC. Empty pericarp5 encodes a pentatricopeptide repeat protein that is required for mitochondrial RNA editing and seed development in maize. Plant Cell, 2013, 25(3):868-883. doi: 10.1105/tpc.112.106781
[82]	Sun F, Wang XM, Bonnard G, Shen Y, Xiu ZH, Li XJ, Gao DH, Zhang ZH, Tan BC. Empty pericarp7 encodes a mitochondrial E-subgroup pentatricopeptide repeat protein that is required for ccmFn editing, mitochondrial function and seed development in maize. Plant J, 2015, 84(2):283-295. doi: 10.1111/tpj.12993
[83]	Yang YZ, Ding S, Wang HC, Sun F, Huang WL, Song S, Xu CH, Tan BC. The pentatricopeptide repeat protein EMP9 is required for mitochondrial ccmB and rps4 transcript editing, mitochondrial complex biogenesis and seed development in maize. New Phytol, 2017, 214(2):782-795. doi: 10.1111/nph.14424 pmid: 28121385
[84]	Li XL, Huang WL, Yang HH, Jiang RC, Sun F, Wang HC, Zhao J, Xu CH, Tan BC. EMP18 functions in mitochondrialatp6 and cox2 transcript editing and is essential to seed development in maize. New Phytol, 2019, 221(2):896-907. doi: 10.1111/nph.2019.221.issue-2
[85]	Qi WW, Tian ZR, Lu L, Chen XZ, Chen XZ, Zhang W, Song RT. Editing of mitochondrial transcripts nad3 and cox2 by Dek10 is essential for mitochondrial function and maize plant development. Genetics, 2017, 205(4):1489-1501. doi: 10.1534/genetics.116.199331
[86]	Li XJ, Gu W, Sun SL, Chen ZL, Chen J, Song WB, Zhao HM, Lai JS. Defective kernel 39 encodes a PPR protein required for seed development in maize. J Integr Plant Biol, 2018, 60(1):45-64. doi: 10.1111/jipb.v60.1
[87]	Ding S, Liu XY, Wang HC, Wang Y, Tang JJ, Yang YZ, Tan BC. SMK6 mediates the C-to-U editing at multiple sites in maize mitochondria. J Plant Physiol, 2019, 240:152992. doi: 10.1016/j.jplph.2019.152992
[88]	Wang Y, Liu XY, Yang YZ, Huang J, Sun F, Lin JS, Gu ZQ, Sayyed A, Xu CH, Tan BC. Empty Pericarp21 encodes a novel PPR-DYW protein that is required for mitochondrial RNA editing at multiple sites, complexes I and V biogenesis, and seed development in maize. PLoS Genet, 2019, 15(8):e1008305. doi: 10.1371/journal.pgen.1008305
[89]	Doniwa Y, Ueda M, Ueta M, Wada A, Kadowaki KI, Tsutsumi N. The involvement of a PPR protein of the P subfamily in partial RNA editing of anArabidopsis mitochondrial transcript. Gene, 2010, 454(1-2):39-46. doi: 10.1016/j.gene.2010.01.008 pmid: 20117193
[90]	Boussardon C, Salone V, Avon A, Berthomé R, Hammani K, Okuda K, Shikanai T, Small I, Lurin C. Two interacting proteins are necessary for the editing of the NdhD-1 site in Arabidopsis plastids. Plant Cell, 2012, 24(9):3684-3694. doi: 10.1105/tpc.112.099507
[91]	Okuda K, Myouga F, Motohashi R, Shinozaki K, Shikanai T. Conserved domain structure of pentatricopeptide repeat proteins involved in chloroplast RNA editing. Proc Natl Acad Sci USA, 2007, 104(19):8178-8183. doi: 10.1073/pnas.0700865104
[92]	Sung TY, Tseng CC, Hsieh MH. The SLO1 PPR protein is required for RNA editing at multiple sites with similar upstream sequences inArabidopsis mitochondria. Plant J, 2010, 63(3):499-511. doi: 10.1111/tpj.2010.63.issue-3
[93]	Verbitskiy D, van der Merwe JA, Zehrmann A, Härtel B, Takenaka M. The E-class PPR protein MEF3 ofArabidopsis thaliana can also function in mitochondrial RNA editing with an additional DYW domain. Plant Cell Physiol, 2012, 53(2):358-367. doi: 10.1093/pcp/pcr182 pmid: 22186180
[94]	Okuda K, Chateigner-Boutin AL, Nakamura T, Delannoy E, Sugita M, Myouga F, Motohashi R, Shinozaki K, Small I, Shikanai T. Pentatricopeptide repeat proteins with the DYW motif have distinct molecular functions in RNA editing and RNA cleavage inArabidopsis chloroplasts. Plant Cell, 2009, 21(1):146-156. doi: 10.1105/tpc.108.064667
[95]	Okuda K, Hammani K, Tanz SK, Peng LW, Fukao Y, Myouga F, Motohashi R, Shinozaki K, Small I, Shikanai T. The pentatricopeptide repeat protein OTP82 is required for RNA editing of plastidndhB and ndhG transcripts. Plant J, 2010, 61(2):339-349. doi: 10.1111/j.1365-313X.2009.04059.x
[96]	Hammani K, Okuda K, Tanz SK, Chateigner-Boutin AL, Shikanai T, Small I. A study of newArabidopsis chloroplast RNA editing mutants reveals general features of editing factors and their target sites. Plant Cell, 2009, 21(11):3686-3699. doi: 10.1105/tpc.109.071472
[97]	Zehrmann A, Van Der Merwe J, Verbitskiy D, Härtel B, Brennicke A, Takenaka M. The DYW-class PPR protein MEF7 is required for RNA editing at four sites in mitochondria ofArabidopsis thaliana. RNA Biol, 2012, 9(2):155-161. doi: 10.4161/rna.18644 pmid: 22258224
[98]	Takenaka M. MEF9, an E-subclass pentatricopeptide repeat protein, is required for an RNA editing event in thenad7 transcript in mitochondria of Arabidopsis. Plant Physiol, 2010, 152(2):939-947. doi: 10.1104/pp.109.151175 pmid: 20018598
[99]	Verbitskiy D, Härtel B, Zehrmann A, Brennicke A, Takenaka M. The DYW-E-PPR protein MEF14 is required for RNA editing at sitematR-1895 in mitochondria of Arabidopsis thaliana. FEBS Lett, 2011, 585(4):700-704. doi: 10.1016/j.febslet.2011.01.037 pmid: 21281638
[100]	Kim SR, Yang JI, Moon S, Ryu CH, An K, Kim KM, Yim J, An G. Rice OGR1 encodes a pentatricopeptide repeat-DYW protein and is essential for RNA editing in mitochondria. Plant J, 2009, 59(5):738-749. doi: 10.1111/tpj.2009.59.issue-5
[101]	Toda T, Fujii S, Noguchi K, Kazama T, Toriyama K. Rice MPR25 encodes a pentatricopeptide repeat protein and is essential for RNA editing ofnad5 transcripts in mitochondria. Plant J, 2012, 72(3):450-460. doi: 10.1111/tpj.2012.72.issue-3
[102]	Zhang ZG, Cui XA, Wang YW, Wu JX, Gu XF, Lu TG. The RNA editing factor WSP1 is essential for chloroplast development in rice. Mol Plant, 2017, 10(1):86-98. doi: 10.1016/j.molp.2016.08.009
[103]	Rugen N, Straube H, Franken LE, Braun HP, Eubel H. Complexome profiling reveals association of PPR proteins with ribosomes in the mitochondria of plants. Mol Cell Proteomics, 2019, 18(7):1345-1362. doi: 10.1074/mcp.RA119.001396 pmid: 31023727
[104]	Chateigner-Boutin AL, Hanson MR. Developmental co-variation of RNA editing extent of plastid editing sites exhibiting similarcis-elements. Nucleic Acids Res, 2003, 31(10):2586-2594. pmid: 12736308
[105]	Yan JJ, Zhang QX, Guan ZY, Wang Q, Li L, Ruan FY, Lin RC, Zou TT, Yin P. MORF9 increases the RNA-binding activity of PLS-type pentatricopeptide repeat protein in plastid RNA editing. Nat Plants, 2017, 3:17037. doi: 10.1038/nplants.2017.37
[106]	Cheng SF, Gutmann B, Zhong X, Ye YT, Fisher MF, Bai FQ, Castleden I, Song Y, Song B, Huang JY, Liu X, Xu X, Lim BL, Bond CS, Yiu SM, Small I. Redefining the structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land plants. Plant J, 2016, 85(4):532-547. doi: 10.1111/tpj.2016.85.issue-4
[107]	Barkan A, Rojas M, Fujii S, Yap A, Chong YS, Bond CS, Small I. A combinatorial amino acid code for RNA recognition by pentatricopeptide repeat proteins. PLoS Genet, 2012, 8(8):e1002910. doi: 10.1371/journal.pgen.1002910
[108]	Petricka JJ, Clay NK, Nelson TM. Vein patterning screens and the defectively organized tributaries mutants inArabidopsis thaliana. Plant J, 2008, 56(2):251-263. doi: 10.1111/j.1365-313X.2008.03595.x
[109]	Chateigner-Boutin AL, Ramos-Vega M, Guevara-García A, Andrés C, De La Luz Gutiérrez-Nava M, Cantero A, Delannoy E, Jiménez LF, Lurin C, Small I, León P. CLB19, a pentatricopeptide repeat protein required for editing of rpoA and clpP chloroplast transcripts. Plant J, 2008, 56(4):590-602. doi: 10.1111/tpj.2008.56.issue-4
[110]	Zhou WB, Cheng YX, Yap A, Chateigner-Boutin AL, Delannoy E, Hammani K, Small I, Huang JR. The Arabidopsis gene YS1 encoding a DYW protein is required for editing of rpoB transcripts and the rapid development of chloroplasts during early growth. Plant J, 2009, 58(1):82-96. doi: 10.1111/j.1365-313X.2008.03766.x
[111]	Mei C, Jiang SC, Lu YF, Wu FQ, Yu YT, Liang S, Feng XJ, Comeras SP, Lu K, Wu Z, Wang XF, Zhang DP. Arabidopsis pentatricopeptide repeat protein SOAR1 plays a critical role in abscisic acid signalling. J Exp Bot, 2014, 65(18):5317-5330. doi: 10.1093/jxb/eru293
[112]	Millar AH, Whelan J, Soole KL, Day DA. Organization and regulation of mitochondrial respiration in plants. Annu Rev Plant Biol, 2011, 62:79-104. doi: 10.1146/arplant.2011.62.issue-1
[113]	Lee CP, Taylor NL, Millar AH. Recent advances in the composition and heterogeneity of the Arabidopsis mitochondrial proteome. Front Plant Sci, 2013, 4:4.
[114]	Zhu CG, Jin GP, Fang P, Zhang Y, Feng XZ, Tang YP, Qi WW, Song RT. Maize pentatricopeptide repeat protein DEK41 affects cis-splicing of mitochondrial nad4 intron 3 and is required for normal seed development. J Exp Bot, 2019, 70(15):3795-3808. doi: 10.1093/jxb/erz193
[115]	Ren RC, Lu XD, Zhao YJ, Wei YM, Wang LL, Zhang L, Zhang WT, Zhang CY, Zhang XS, Zhao XY. Pentatricopeptide repeat protein DEK40 is required for mitochondrial function and kernel development in maize. J Exp Bot, 2019, 70(21):6163-6179. doi: 10.1093/jxb/erz391
[116]	Hirst J. Mitochondrial complex I. Annu Rev Biochem, 2013, 82:551-575. doi: 10.1146/annurev-biochem-070511-103700 pmid: 23527692
[117]	Noctor G, De Paepe R, Foyer CH. Mitochondrial redox biology and homeostasis in plants. Trends Plant Sci, 2007, 12(3):125-134. doi: 10.1016/j.tplants.2007.01.005
[118]	Hao YY, Wang YL, Wu MM, Zhu XP, Teng X, Sun YL, Zhu JP, Zhang YY, Jing RN, Lei J, Li JF, Bao XH, Wang CM, Wang YH, Wan JM. The nuclear-localized PPR protein OsNPPR1 is important for mitochondrial function and endosperm development in rice. J Exp Bot, 2019, 70(18):4705-4720. doi: 10.1093/jxb/erz226
[119]	Wu J, Sun YF, Zhao YN, Zhang J, Luo L, Li M, Wang JL, Yu H, Liu GF, Yang LS, Xiong GS, Zhou JM, Zuo JR, Wang YH, Li JY. Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species. Cell Res, 2015, 25(5):621-633. doi: 10.1038/cr.2015.46
[120]	Young TE, Gallie DR. Regulation of programmed cell death in maize endosperm by abscisic acid. Plant Mol Biol, 2000, 42(2):397-414. pmid: 10794539
[121]	Young TE, Gallie DR, Demason DA. Ethylene-mediated programmed cell death during maize endosperm development of wild-type andshrunken2 genotypes. Plant Physiol, 1997, 115(2):737-751. pmid: 12223841
[122]	Hahn A, Vonck J, Mills DJ, Meier T, Kühlbrandt W. Structure, mechanism, regulation of the chloroplast ATP synthase. Science, 2018, 360(6389): eaat4318. doi: 10.1126/science.aat4318
[123]	Ding YH, Liu NY, Tang ZS, Liu J, Yang WC. Arabidopsis GLUTAMINE-RICH PROTEIN23 is essential for early embryogenesis and encodes a novel nuclear PPR motif protein that interacts with RNA polymerase II subunit III. Plant Cell, 2006, 18(4):815-830. doi: 10.1105/tpc.105.039495
[124]	Hammani K, Gobert A, Hleibieh K, Choulier L, Small I, Giegé P. AnArabidopsis dual-localized pentatricopeptide repeat protein interacts with nuclear proteins involved in gene expression regulation. Plant Cell, 2011, 23(2):730-740. doi: 10.1105/tpc.110.081638
[125]	Martín-Trillo M, Cubas P. TCP genes: a family snapshot ten years later. Trends Plant Sci, 2010, 15(1):31-39. doi: 10.1016/j.tplants.2009.11.003 pmid: 19963426
[126]	Mei C, Jiang SC, Lu YF, Wu FQ, Yu YT, Liang S, Feng XJ, Comeras SP, Lu K, Wu Z, Wang XF, Zhang DP. Arabidopsis pentatricopeptide repeat protein SOAR1 plays a critical role in abscisic acid signalling. J Exp Bot, 2014, 65(18):5317-5330. doi: 10.1093/jxb/eru293

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

玉米(Zea mays)					拟南芥(Arabidopsis thaliana)					水稻(Oryza sativa)
PPR编辑蛋白	目的基因	编辑位点	蛋白定位	参考文献	PPR编辑蛋白	目的基因	编辑位点	蛋白定位	参考文献	PPR编辑蛋白	目的基因	编辑位点	蛋白定位	参考文献
ZmSMK1	nad7	C836	线粒体	[79]	PPR596	rps3	C1344	线粒体	[89]	OGR1	nad4	C401/416/443	线粒体	[100]
ZmSMK4	cox1	C1489	线粒体	[80]	CRR4	ndhD	C1	叶绿体	[90]		nad2	C1457
ZmEMP5	rpl16	C458	线粒体	[81]	CRR21	ndhD	C2	叶绿体	[91]		ccmC	C458
	nad9	C190/C356			SLO1	nad4	C449	线粒体	[92]		cox2	C167
	cox3	C245/C257				nad9	C328				cox3	C572
ZmEMP7	ccmFn	C1553	线粒体	[82]	MEF3	ATP4	C89	线粒体	[93]	MPR25	nad5	C1580	线粒体	[101]
ZmEMP9	ccMb	C43	线粒体	[83]	CRR22	ndhB	C7	叶绿体	[94]	WSP1	ndhD	C878	叶绿体	[102]
ZmEMP9	rps4	C335				ndhD	C5				rps14	C80
ZmEMP18	atp6	C635	线粒体	[84]	CRR28	rpoB	C3	叶绿体	[94]		rpoB	C467/545/560
ZmEMP18	cox2	C449				ndhB	C2
ZmDEK10	cox2	C550	线粒体	[85]		ndhD	C3
ZmDEK39	nad3	C247/C275	线粒体	[86]	OTP82	ndhB	C9	叶绿体	[95]
ZmSMK6	nad1	C740	线粒体	[87]		ndhG	C1
	nad4L	C110			OTP85	ndhD	C116/494	叶绿体	[96]
	nad7	C739			OTP86	rps14	C37161	叶绿体	[96]
	mttb	C138/139			MEF7	cob	C206/325	线粒体	[97]
ZmEMP21	nad7	C77	线粒体	[88]		ndh2	C1433
	atp1	C1292				nad4L	C41
	atp8	C437			MEF9	nad7	C200	线粒体	[98]
	nad3	C275			MEF14	matR	C1895	线粒体	[99]

PPR蛋白在植物细胞器组分转录后调控中的作用机制

The role of PPR proteins in posttranscriptional regulation of organelle components in plants

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 4

参考文献 126

相关文章 1

编辑推荐

Metrics