遗传 ›› 2014, Vol. 36 ›› Issue (4): 309-318.doi: 10.3724/SP.J.1005.2014.0309

• 综述 • 上一篇    下一篇

基因转录后调控在DNA损伤反应中的重要功能

林德玲1, 2, 罗瑛1, 宋宜2   

  1. 1. 昆明理工大学医学院, 昆明 650500; 2. 军事医学科学院放射与辐射医学研究所, 北京 100850
  • 收稿日期:2013-10-10 修回日期:2014-01-08 出版日期:2014-04-20 发布日期:2014-03-20
  • 通讯作者: 罗瑛, 博士, 教授, 研究方向:分子遗传学。E-mail: luoyingabc@yahoo.com E-mail:luoyingabc@yahoo.com
  • 作者简介:林德玲, 硕士, 专业方向:遗传学。E-mail: lindeling615@163.com
  • 基金资助:

    国家自然科学基金项目(编号:31201014, 81372252)资助

The post-transcriptional regulation of the DNA damage response

Deling Lin1,2, Ying Luo1, Yi Song2   

  1. 1. Medical Faculty of Kunming University of Science and Technology, Kunming 650500, China; 
    2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2013-10-10 Revised:2014-01-08 Online:2014-04-20 Published:2014-03-20

摘要:

DNA损伤发生时, 细胞会激活一系列复杂的信号网络来调控细胞周期检查, 完成DNA损伤修复或当损伤超过修复能力时诱导凋亡, 这一信号网络被称为DNA损伤反应(DNA damage response, DDR)。以往DDR信号网络的研究主要集中于基因转录调控和蛋白共价修饰对功能分子的稳定性和活性调控。近年来, mRNA稳定性调控和mRNA 翻译调控等基因转录后调控机制在DDR中的重要作用引起研究者越来越多的关注。研究证明:多种microRNAs和RNA结合蛋白(RNA-binding proteins, RBPs)在转录后水平调控诸多重要功能蛋白的表达, 在DDR信号网络中起着不可或缺的作用。文章针对DDR反应中转录后调控的研究进展以及参与其中的microRNAs和RBPs进行阐述和讨论。

关键词: DNA损伤反应, microRNAs, RNA结合蛋白, 转录后调控

Abstract:

In response to DNA damage, a complex signaling network called DNA damage response (DDR) would be activated in cells, to arrest the cell cycle and initiate DNA repair. Previous studies were mainly focused on the transcriptional regulation of gene and covalent modification of protein . In recent years, mRNA stability and translation in DDR attracted more and more attention. Emerging evidence suggests that microRNAs and RNA-binding proteins (RBPs) play critical roles in protecting the heritable genome through participating in the regulation of the DNA damage response. In this review, we discuss the most recent findings regarding the post-transcriptional regulation of the DDR by microRNAs and RBPs.

Key words: DNA damage response, microRNAs, RNA-binding protein, post-transcriptional regulation