UFMylation类泛素修饰在结核分枝杆菌感染免疫中的作用与机理

doi:10.16288/j.yczz.24-259

遗传

• 综述 •

UFMylation类泛素修饰在结核分枝杆菌感染免疫中的作用与机理

廖怡然¹，张其奥¹，李佩波²，谢建平^1，2

1. 西南大学生命科学学院现代生物医药研究所，重庆 400715

2. 重庆市公共卫生救治中心，重庆 400036

收稿日期:2024-10-30 修回日期:2024-12-31 出版日期:2025-01-06 发布日期:2025-01-06
基金资助:
国家自然科学基金项目;2023年重庆市公共卫生重点专科（学科）建设项目，重庆市科卫联合医学科研项目

The role and mechanism of UFMylation, a ubiquitin-like modi-fication, in Mycobacterium tuberculosis infection immunity

Yiran Liao¹, Qiao Zhang¹,Peibo Li², Jianping Xie^1,2

1 Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China

2. Chongqing Public Health Medical Center, Chongqing 400036, China

Received:2024-10-30 Revised:2024-12-31 Published:2025-01-06 Online:2025-01-06

摘要/Abstract

摘要：

Ubiquitin-fold modifier 1（UFM1）是一种在原核生物和大多数真核生物中广泛存在的Ⅰ型类泛素蛋白，其介导的UFMylaiton修饰参与调节多种细胞生化过程。近年来UFM1系统在内质网稳态调节中的重要性被逐步发现和重视。结核分枝杆菌感染引发的内质网应激是结核病发病进程的重要环节，因而UFM1系统有望成为抗结核治疗药物研发的新靶标。本文对UFM1系统和其介导的UFMylation途径进行了介绍，并重点综述了UFM1系统参与内质网稳态调节的最新进展及其在结核病治疗中的潜在价值，以期为开发新型抗结核治疗方法提供新的方向。

关键词: UFMylation, UFM1系统, 结核病

Abstract:

Ubiquitin-fold modifier 1 （UFM1） is a ubiquitin-like type I protein widely present in prokaryote and most eukaryote. UFMylaiton, mediated by UFM1, is involved in the regulation of a variety of cellular biochemical processes. Recently, the importance of UFM1 system in endoplasmic reticulum homeostasis regulation has been gradually discovered and emphasized. Endoplasmic reticulum stress caused by Mycobacterium tuberculosis is an important link in the progression of tuberculosis, so UFM1 system is expected to become a new target for the development of anti-tuberculosis drugs. In this review, we provide a brief overview of the UFM1 system and UFMylation pathway, and summarize the recent advances in understanding UFM1's role in ER homeostasis regulation and its potential value in TB treatment, with the aim of offering new insight and direction for developing novel therapeutic strategies against tuberculosis.

Key words: UFMylation, UFM1 system, tuberculosis

廖怡然, 张其奥, 李佩波, 谢建平. UFMylation类泛素修饰在结核分枝杆菌感染免疫中的作用与机理[J]. 遗传, doi: 10.16288/j.yczz.24-259.

Yiran Liao, Qiao Zhang, Peibo Li, Jianping Xie. The role and mechanism of UFMylation, a ubiquitin-like modi-fication, in Mycobacterium tuberculosis infection immunity[J]. Hereditas(Beijing), doi: 10.16288/j.yczz.24-259.

[1]	张其奥, 王子路, 李佩波, 谢建平. USP18介导的蛋白质去ISG化及其在结核病等传染病中的作用[J]. 遗传, 2023, 45(11): 998-1006.
[2]	刘洋, 王邦兴, 刘志永, 韩轶, 谭耀驹, 李昕洁, 刘健雄, 谭守勇, 张天宇. 非一线抗结核药物耐药机制及耐药性诊断研究进展[J]. 遗传, 2016, 38(10): 928-939.

UFMylation类泛素修饰在结核分枝杆菌感染免疫中的作用与机理

The role and mechanism of UFMylation, a ubiquitin-like modi-fication, in Mycobacterium tuberculosis infection immunity

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 2

编辑推荐

Metrics