生物力学——胚胎血管系统发育研究新视野

doi:10.3724/SP.J.1005.2012.01123

遗传 ›› 2012, Vol. 34 ›› Issue (9): 1123-1132.doi: 10.3724/SP.J.1005.2012.01123

生物力学——胚胎血管系统发育研究新视野

谢翔, 胡建军, 王贵学

重庆大学生物工程学院力-发育生物学研究室, 生物流变科学与技术教育部重点实验室, 重庆市血管植入物工程实验室, 重庆 400044

收稿日期:2012-03-01 修回日期:2012-06-30 出版日期:2012-09-20 发布日期:2012-09-25
通讯作者: 王贵学 E-mail:wanggx@cqu.edu.cn
基金资助:
国家重大科学研究计划项目(编号：2012CB945101)和重庆国家生物产业基地公共实验中心建设项目(编号：发改办高技[2008]1692号)资助

Advance in biomechanical study of embryonic vascular system de-velopment

XIE Xiang, HU Jian-Jun, WANG Gui-Xue

Key Laboratory of Biorheology and Technology (Chongqing University), Ministry of Education; Chongqing Engineering Laboratory in Vascular Implants; Laboratory of Mechano-developmental Biology, Bioengineering College of Chongqing University; Chongqing 400044, China

Received:2012-03-01 Revised:2012-06-30 Online:2012-09-20 Published:2012-09-25

摘要/Abstract

摘要： 胚胎血管系统发育是一个复杂的过程, 其进程受多种刺激和抑制信号的调控, 这些信号必须协调作用, 以确保血管发育的每个阶段得以正常进行。血管发育过程在一定程度上是由基因控制的, 而且其研究也在很广的范围展开。但是近年研究发现, 生物力学作用是胚胎血管发育的必要因素, 胚胎血管发育过程中涉及到不同的细胞生物力学机制。文章主要就生物力学因素在血管系统发育过程中所起的作用及最新相关研究进展作一概述。

关键词: 生物力学, 血管发育, 细胞分化, 细胞迁移, 动静脉分化, 模式建成

Abstract: Embryonic vascular system development is a complex process, whose progress is regulated by a variety of the stimulation and inhibition signals, and these signals must play synergistic effect so as to ensure that each stage of vascular development can proceed normally. The vascular development is controlled by the gene to a certain extent, and has received extensive attention. Recent studies have revealed the biomechanical role is necessary to embryonic vascular development, in which different mechanism of cell biomechanics is involved. In this review, we summarize the latest research progress on the role of biomechanical factors during embryonic vascular system development.

Key words: biomechanics, vascular development, cell differentiation, cell migration, arterial-venous differentiation, modeling

谢翔，胡建军，王贵学. 生物力学——胚胎血管系统发育研究新视野[J]. 遗传, 2012, 34(9): 1123-1132.

XIE Xiang, HU Jian-Jun, WANG Gui-Xue. Advance in biomechanical study of embryonic vascular system de-velopment[J]. HEREDITAS, 2012, 34(9): 1123-1132.

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生物力学——胚胎血管系统发育研究新视野

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