遗传 ›› 2012, Vol. 34 ›› Issue (9): 1123-1132.doi: 10.3724/SP.J.1005.2012.01123
谢翔, 胡建军, 王贵学
收稿日期:
2012-03-01
修回日期:
2012-06-30
出版日期:
2012-09-20
发布日期:
2012-09-25
通讯作者:
王贵学
E-mail:wanggx@cqu.edu.cn
基金资助:
国家重大科学研究计划项目(编号:2012CB945101)和重庆国家生物产业基地公共实验中心建设项目(编号:发改办高技[2008]1692号)资助
XIE Xiang, HU Jian-Jun, WANG Gui-Xue
Received:
2012-03-01
Revised:
2012-06-30
Online:
2012-09-20
Published:
2012-09-25
摘要: 胚胎血管系统发育是一个复杂的过程, 其进程受多种刺激和抑制信号的调控, 这些信号必须协调作用, 以确保血管发育的每个阶段得以正常进行。血管发育过程在一定程度上是由基因控制的, 而且其研究也在很广的范围展开。但是近年研究发现, 生物力学作用是胚胎血管发育的必要因素, 胚胎血管发育过程中涉及到不同的细胞生物力学机制。文章主要就生物力学因素在血管系统发育过程中所起的作用及最新相关研究进展作一概述。
谢翔,胡建军,王贵学. 生物力学——胚胎血管系统发育研究新视野[J]. 遗传, 2012, 34(9): 1123-1132.
XIE Xiang, HU Jian-Jun, WANG Gui-Xue. Advance in biomechanical study of embryonic vascular system de-velopment[J]. HEREDITAS, 2012, 34(9): 1123-1132.
[1] Tallquist MD, Soriano P, Klinghoffer RA. Growth factor signaling pathways in vascular development. Oncogene, 1999, 18(55): 7917-7932.[2] Ribatti D. Genetic and epigenetic mechanisms in the early development of the vascular system. J Anat, 2006, 208(2): 139-152.[3] Carmeliet P. Angiogenesis in health and disease. Nat Med, 2003, 9(6): 653-660.[4] Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature, 2000, 407(6801): 242-248.[5] Hellström M, Kalén M, Lindahl P, Abramsson A, Betsholtz C. Role of PDGF-B and PDGFR-beta in re-cruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development, 1999, 126(14): 3047-3055.[6] Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol, 1995, 11: 73-91.[7] Wilting J, Brand-Saberi B, Kurz H, Christ B. Development of the embryonic vascular system. Cell Mol Biol Res, 1995, 41(4): 219-232.[8] Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elas-ticity directs stem cell lineage specification. Cell, 2006, 126(4): 677-689.[9] Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yama-shita JK, Obi S, Ohura N, Matsushita A, Kamiya A, Ando J. Fluid shear stress induces differentiation of Flk-1-posi-tive embryonic stem cells into vascular endo-thelial cells in vitro. Am J Physiol Heart Circ Physiol, 2005, 288(4): 1915-1924.[10] Yamamoto K, Takahashi T, Asahara T, Ohura N, Sokabe T, Kamiya A, Ando J. Proliferation, differentiation, and tubeformation by endothelial progenitor cells in response to shear stress. J Appl Physiol, 2003, 95(5): 2081-2088.[11] Wang H, Riha GM, Yan SY, Li M, Chai H, Yang H, Yao QZ, Chen CY. Shear stress induces endothelial differen-tiation from a murine embryonic mesenchymal progenitor cell line. Arterioscler Thromb Vasc Biol, 2005, 25(9): 1817-1823.[12] Schmelter M, Ateghang B, Helmig S, Wartenberg M, Sauer H. Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced car-diovascular differentiation. FASEB J, 2006, 20(8): 1182-1184.[13] Shimizu N, Yamamoto K, Obi S, Kumagaya S, Masumura T, Shimano Y, Naruse K, Yamashita JK, Igarashi T, Ando J. Cyclic strain induces mouse embryonic stem cell differen-tiation into vascular smooth muscle cells by activating PDGF receptor. J Appl Physiol, 2008, 104(3): 766-772.[14] Steinberg MS, Gilbert SF. Directed movements and selective adhesion of embryonic amphibian cells. J Exp Zool, 2004, 301(9): 701-706.[15] Krieg M, Arboleda-Estudillo Y, Puech PH, Käfer J, Graner F, Müller DJ, Heisenberg CP. Tensile forces govern germ-layer organization in zebrafish. Nat Cell Biol, 2008, 10(4): 429-436.[16] Drake CJ, Fleming PA. Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood, 2000, 95(5): 1671-1679.[17] Schmidt A, Brixius K, Bloch W. Endothelial Precursor cell migration during vasculogenesis. Circ Res, 2007, 101(2): 125-136.[18] Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature, 1996, 380(6573): 435-439.[19] Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature, 1995, 376 (6535): 62-66.[20] Shoji W, Isogai S, Sato-Maeda M, Obinata M, Kuwada JY. Semaphorin3a1 regulates angioblast migration and vascu-lar development in zebrafish embryos. Develop-ment, 2003, 130(14): 3227-3236.[21] Chen T, Bai H, Shao Y, Arzigian M, Janzen V, Attar E, Xie Y, Scadden DT, Wang ZZ. SDF- 1/CXCR4 signaling modi-fies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro. Stem Cells, 2007, 25(2): 392-401.[22] Troyanovsky B, Levchenko T, Månsson G, Matvijenko O, Holmgren L. Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation. J Cell Bio, 2001, 152(6): 1247-1254.[23] Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, Birot O, Ming Y, Kvanta A, Edholm D, Aspenström P, Kissil J, Claesson-Welsh L, Shimono A, Holmgren L. Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Gene Dev, 2007, 21(16): 2055- 2068.[24] Pinter E, Barreuther M, Lu T, Imhof BA, Madri JA. Plate-let-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vascu-logenesis in the murine conceptus. Am J Pathol, 1997, 150(5): 1523-1530.[25] Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oost-huyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF- mediated endothelial survival and angiogenesis. Cell, 1999, 98(2): 147-157.[26] George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fi-bronectin. Development, 1993, 119(4): 1079-1091.[27] Lamalice L, Le Boeuf F, Huot J. Endothelial cell migra-tion during angiogenesis. Circ Res, 2007, 100(6): 782-794.[28] Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol, 2003, 161(6): 1163-1177.[29] Wang D, Anderson JC, Gladson CL. The role of the ex-tracellular matrix in angiogenesis in malignant glioma tumors. Brain Pathol, 2005, 15(4): 318-326.[30] Li S, Huang NF, Hsu S. Mechanotransduction in endothe-lial cell migration. J Cell Bio Chem, 2005, 96(6): 1110-1126.[31] Yeh CR, Chiu JJ, Lee CI, Lee PL, Shih YT, Sun JS, Chien S, Cheng CK. Estrogen augments shear stress-induced signaling and gene expression in osteoblast-like cells via estrogen receptor -mediated expression of β1-integrin. J Bone Miner Res, 2010, 25(3): 627-639.[32] Loufrani L, Retailleau K, Bocquet A, Dumont O, Danker K, Louis H, Lacolley P, Henrion D. Key role of α1β1- in-tegrin in the activation of pi3-kinase-akt by flow (shear stress) in resistance arteries. Am J Physiol-Heart C, 2008, 294(4): H1906-H1913.[33] Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kin-bara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. Localized α4 integrin phosphory-lation directs shear stress-induced endothelial cell align-ment. Circ Res, 2008, 103(2): 177-185.[34] Lee DY, Yeh CR, Chang SF, Lee PL, Chien S, Cheng CK, Chiu JJ. Integrin-mediated expression of bone forma-tion-related genes in osteoblast-like cells in response to fluid shear stress: Roles of extracellular matrix, shc, and mitogen-activated protein kinase. J Bone Miner Res, 2008, 23(7): 1140-1149.[35] Canty EG, Starborg T, Lu YH, Humphries SM, Holmes DF, Meadows RS, Huffman A, O'Toole ET, Kadler KE. Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon. J Biol Chem, 2006, 281(50): 38592-38598.[36] Chiquet M, Reneda AS, Huber F, Fluck M. How do fibro-blasts translate mechanical signals into changes in ex-tracellular matrix production? Matrix Biol, 2003, 22(1): 73-80.[37] Nguyen TD, Liang R, Woo SLY, Burton SD, Wu CF, Al-marza A, Sacks MS, Abramowitch S. Effects of cell seed-ing and cyclic stretch on the fiber remodeling in an ex-tracellular matrix- derived bioscaffold. Tissue Eng Part A, 2009, 15(4): 957-963.[38] Wang KC, Garmire LX, Young A, Nguyen P, Trinh A, Subramaniam S, Wang NP, Shyy JY, Li YS, Chien S. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci USA, 2010, 107(7): 3233-3239.[39] Weinberg EJ, Mack PJ, Schoen FJ, García-Cardeña G, Kaazempur Mofrad MR. Hemodynamic environments from opposing sides of human aortic valve leaflets evoke distinct endothelial phenotypes in vitro. Cardiovasc Eng, 2010, 10(1): 5-11.[40] Gerthoffer WT. Mechanisms of vascular smooth muscle cell migration. Circ Res, 2007, 100(5): 607-621.[41] North TE, Goessling W, Peeters M, Li PL, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. Hematopoietic stem cell development is depend-ent on blood flow. Cell, 2009, 137(4): 736-748.[42] Adamo L, Naveiras O, Wenzel PL, McKinney-Freeman S, Mack PJ, Gracia-Sancho J, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, García-Cardeña G, Daley GQ. Biomechanical forces promote embryonic haematopoiesis. Nature, 2009, 459 (7250): 1131-1135.[43] Rhodes KE, Gekas C, Wang YL, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HKA. The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell, 2008, 2(3): 252-263.[44] Jones EAV, le Noble F, Eichmann A. What determines blood vessel structure? Genetic prespecification vs. hemodynamics. Physiology, 2006, 21(6): 388-395.[45] Schaper W, Scholz D. Factors regulating arteriogenesis. Arterioscler Thromb Vasc Biol, 2003, 23(7): 1143-1151.[46] van Royen N, Piek JJ, Buschmann I, Hoefer I, Voskuil M, Schaper W. Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease. Cardiovasc Res, 2001, 49(3): 543-553.[47] Groenendijk BCW, Hierck BP, Vrolijk J, Baiker M, Pourquie MJBM, Gittenberger-de Groot AC, Poelmann RE. Changes in shear stress-related gene expression after experimentally altered venous return in the chicken embryo. Circ Res, 2005, 96(12): 1291-1298.[48] le Noble F, Klein C, Tintu A, Pries A, Buschmann I. Neu-ral guidance molecules, tip cells, and mechanical factors in vascular development. Cardiovasc Res, 2008, 78(2): 232-241.[49] Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, Lawson ND. MicroRNA-mediated integration of haemo-dynamics and Vegf signalling during angiogenesis. Nature, 2010, 464 (7292): 1196-1200.[50] le Noble F, Fleury V, Pries A, Corvol P, Eichmann A, Reneman RS. Control of arterial branching morphogenesis in embryogenesis: go with the flow. Cardiovasc Res, 2005, 65(3): 619-628.[51] Bennett SH, Eldridge MW, Zaghi D, Zaghi SE, Milstein JM, Goetzman BW. Form and function of fetal and neo-natal pulmonary arterial bifurcations. Am J Physiol Heart Circ Physiol, 2000, 279(6): H3047-H3057.[52] Djonov V, Kurz HM, Burri PH. Optimality in the devel-oping vascular system: branching remodeling by means of intussusception as an efficient adaptation mechanism. Dev Dyn, 2002, 224(4): 391-402.[53] Murray CD. The physiological principle of minimum work 1: The vascular system and the cost of blood volume. Proc Natl Acad Sci USA, 1926, 12(3): 207-214.[54] Zhong TP, Childs S, Leu JP, Fishman MC. Gridlock signaling pathway fashions the first embryonic artery. Nature, 2001, 414(6860), 216-220.[55] le Noble F, Moyon D, Pardanaud L, Yuan L, Djonov V, Matthijsen R, Bréant C, Fleury V, Eichmann A. Flow regulates arterial-venous differentiation in the chick em-bryo yolk sac. Development, 2003, 131(2): 361-375.[56] Eichmann A, Yuan L, Moyon D, Lenoble F, Pardanaud L, Breant C. Vascular development: from precursor cells to branched arterial and venous networks. Int J Dev Biol, 2005, 49(2-3): 259-267.[57] Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science, 2009, 326(5950): 294-298.[58] Isogai S, Lawson ND, Torrealday S, Horiguchi M, Weinstein BM. Angiogenic network formation in the develop-ing vertebrate trunk. Development, 2003, 130(21): 5281-5290.[59] Resnick N, Collins T, Atkinson W, Bonthron DT, Dewey CF Jr, Gimbrone MA Jr. Platelet- derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci USA, 1993, 90(10): 4591-4595.[60] Davis ME, Grumbach IM, Fukai T, Cutchins A, Harrison DG. Shear stress regulates endothelial nitric-oxide syn-thase promoter activity through nuclear factor kappaB binding. J Biol Chem, 2004, 279(1): 163-168.[61] Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou DE, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML. Klf2 is an es-sential regulator of vascular hemodynamic forces in vivo. Dev Cell, 2006, 11(6): 845-857[62] Mammoto A, Connor KM, Mammoto T, Yung C W, Huh D, Aderman CM, Mostoslavsky G, Smith LEH, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature, 2009, 457(7233): 1103-1108.[63] Ingber DE. Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circ Res, 2002, 91(10): 877-887.[64] Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner DG, Damsky CH. Focal adhesion kinase is re-quired for blood vessel morphogenesis. Circ Res, 2003, 92(3): 300-307.[65] Ili? D, Furuta Y, Kanazawa S, Takeda N, Sobue K, Naka-tsuji N, Nomura S, Fujimoto J, Okada M, Yamamoto T, Aizawa S. Reduced cell motility and enhanced focal adhe-sion contact formation in cells from FAK-deficient mice. Nature, 1995, 377(6549): 539-544.[66] Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oost-huyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gitten-berger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF- mediated endothelial survival and angiogenesis. Cell, 1999, 98(2): 147-157.[67] Shay-Salit A, Shushy M, Wolfovitz E, Yahav H, Breviario F, Dejana E, Resnick N. VEGF receptor 2 and the adher-ens junction as a mechanical transducer in vascular endo-thelial cells. Proc Natl Acad Sci USA, 2002, 99(14): 9462-9467.[68] Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao GY, DeLisser H, Schwartz MA. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature, 2005, 437(7057): 426-431.[69] Keller PJ, Schmidt AD, Wittbrodt J, Stelzer EH. Recon-struction of zebrafish early embryonic development by scanned light sheet microscopy. Science, 2008, 322(5904): 1065- 1069.[70] Puech PH, Taubenberger A, Ulrich F, Krieg M, Muller DJ, Heisenberg CP. Measuring cell adhesion forces of primary gastrulating cells from zebrafish using atomic force mi-croscopy. J Cell Sci, 2005, 118(Pt 18): 4199-4206.[71] Stoletov K, Fang LH, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Cro-sier P, Witztum JL, Klemke RL, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res, 2009, 104(8): 952-960.[72] Bakkers J. Zebrafish as a model to study cardiac devel-opment and human cardiac disease. Cardiovasc Res, 2011, 91(2): 279-288. |
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