遗传 ›› 2012, Vol. 34 ›› Issue (9): 1114-1122.doi: 10.3724/SP.J.1005.2012.01114
王旭, 熊敬维
收稿日期:2012-03-07
修回日期:2012-06-07
出版日期:2012-09-20
发布日期:2012-09-25
通讯作者:
熊敬维
E-mail:jingwei_xiong@pku.edu.cn
基金资助:国家重点基础研究发展计划(973计划)项目(编号:2010CB529503, 2012CB944501)和国家自然科学基金面上项目(编号:30971662)资助
WANG Xu, XIONG Jing-Wei
Received:2012-03-07
Revised:2012-06-07
Online:2012-09-20
Published:2012-09-25
摘要： 心血管系统是胚胎发育中最先形成的器官之一, 为机体提供营养成分和氧气。血管发育包括两部分, 一是内皮祖细胞(Angioblast)聚集形成血管原基(Vasculogenesis), 二是从已有血管形成新的血管分支(Angiogenesis)。此后由初级内皮细胞管召集平滑肌细胞形成功能性血管(Vessel maturation)。内皮祖细胞起源途径包括：由Flk1阳性中胚层细胞到成血成血管细胞(Hemangioblast)到血管内皮祖细胞; 或由Flk1阳性中胚层细胞直接到血管内皮祖细胞。Flk1阳性中胚层细胞受到vegf、flk1、cloche、lycat、etsrp等关键基因或信号通路的调节, 其中核心问题是原肠期中胚层如何形成Flk1阳性中胚层细胞及进一步分化成血管内皮祖细胞和成血血管细胞。文章集中评述内皮祖细胞发育、分化及其分子遗传调控机制, 并展望本领域未来发展方向。
王旭，熊敬维. 血管内皮细胞发育及分子机制[J]. 遗传, 2012, 34(9): 1114-1122.
WANG Xu, XIONG Jing-Wei. Vascular endothelial cell development and underlying mechanisms[J]. HEREDITAS, 2012, 34(9): 1114-1122.
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