摘要： 采用JL-02多位点探针和Southern杂交对Wistar大鼠基因组进行了DNA指纹分析，并对国内最具有典型的6个地区9个Wistar大鼠群体内和群体间进行了DNA指纹分析比较。结果表明，DNA指纹图较好地反映了封闭群动物的遗传本质，具有良好的多态性。同一群体不同个体间Wistar大鼠遗传距离主要为0.2~0.6，将不同群体的Wistar大鼠DNA指纹图带进行分析表明，所有群体间的DNA指纹图的遗传距离在0.2~0.7。
Abstract:DNA fingerprinting of Wistar rat were studied with JL-02 Mulilocus probe and Southern hybridization,and comparing with different individuals of nine groups Wistar rat from six national classical area and different groups.It was indicated that DNA fingerprinting could reflect genetic material of outbred strain rat,and were more polymorphic.The genetic distances of Wistar rat were distributed for 0.2~0.6 among different individuals within same groups，and the genetic distances of Wistar rat were distributed for 0.2~0.7 among different groups．