关键词: p53, LIF, SNP, p53通路, 胚胎植入

Abstract: p53 is an important tumor suppressor gene andone of the key genes in sensing and regulating responses to the environmental stress. Recent study showed that cold winter temperature naturally selectedp53 Arg72 in eastern Asian popu-lation, suggestingthat p53 playsa role in reproduction. It has also been reported that some SNPs of p53, Mdm2(Murine double minute 2), MdmX and Hausp (Herpes virus-associated ubiquitin-specific protease) in p53 pathway are associated with the risk of the women’s reproduction disorder. p53 regulates the LIF (leukaemia inhibitory factor) expression level by its DBD domain, and thus contributes to female reproduction by affecting the embryo implantation process. The MDM2, MDMX, and HAUSP proteins regulatesthelevel and activity of p53 protein, which are critical for the appropriate p53 response in the embryo implantation process. The members of p53 family, p63 and p73, also play roles in female reproduction through other pathways. p63 has been implicated as a major regulator of oocyte death following treatment with irradiation and chemotherapeutic drugs, which prevents fetal malformation. p73 regulates the formation of spindle assembly complex(SAC). The dysfunction of SAC results in poor blastocyst quality and defects in kinetochore–microtubule associations, which leads to aneuploidy. This review summarized the function of p53 family and its pathway related proteins in female reproduction, pointed out a new method in improving the success rate in IVF-ET, and provided a new diagnosis idea for unexplainedinfertile women. It will facilitate personalized strategies in the infertility therapy.

Key words: p53, LIF, SNP, p53 pathway, embryo implantation