[1] Risau W, Flamme I. Vasculogenesis. Annu Rev Cell Dev Biol, 1995, 11: 73-91.[2] Lawson ND, Scheer N, Pham VN, Kim CH, Chitnis AB, Campos-Ortega JA, Weinstein BM. Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development, 2001, 128(19): 3675-3683.[3] Lawson ND, Vogel AM, Weinstein BM. Sonic hedgehog and vascular endothelial growth factor act up-stream of the notch pathway during arterial endothelial differentiation. Dev Cell, 2002, 3(1): 127-136.[4] You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY. Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature, 2005, 435(7038): 98-104.[5] Murray PDF. The development in vitro of the blood of the early chick embryo. Proc R Soc London Ser B-Contain Pap A Biol Character, 1932, 111(773): 497-521.[6] Pardanaud L, Luton D, Prigent M, Bourcheix LM, Catala M, Dieterlen-Lievre F. Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis. Development, 1996, 122(5): 1363-1371.[7] Xiong JW. Molecular and developmental biology of the hemangioblast. Dev Dyn, 2008, 237(5): 1218-1231.[8] Eichmann A, Marcelle C, Bréant C, Le Douarin NM. Two molecules related to the VEGF receptor are expressed in early endothelial cells during avian embryonic development. Mech Dev, 1993, 42(1-2): 33-48.[9] Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, Declercq C, Pawling J, Moons L, Collen D, Risau W, Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature, 1996, 380(6573): 435-439.[10] Eichmann A, Corbel C, Nataf V, Vaigot P, Bréant C, Le Douarin NM. Ligand-dependent development of the en-dothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2. Proc Natl Acad Sci USA, 1997, 94(10): 5141-5146.[11] Giles PB, Candy CL, Fleming PA, Owens RW, Argraves WS, Drake CJ. VEGF directs newly gastrulated mesoderm to the endothelial lineage. Dev Biol, 2005, 279(1): 169-178.[12] Evans MJ, Kaufman MJ. Establishment in culture of pluripotential cells from mouse embryos. Nature, 1981, 292(5819): 154-156.[13] Vittet D, Prandini MH, Berthier R, Schweitzer A, Mar-tin-Sisteron H, Uzan G, Dejana E. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood, 1996, 88(9): 3424-3431.[14] Kennedy M, Firpo M, Chol K, Wall C, Robertson S, Kabrun N, Keller G. A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature, 1997, 386(6624): 488-493.[15] Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G. A common precursor for hematopoietic and endothelial cells. Development, 1998, 125(4): 725-732.[16] Nishikawa SI, Nishikawa S, Hirashima M, Matsuyoshi N, Kodama H. Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development, 1998, 125(9): 1747-1757.[17] Chung YS, Zhang WJ, Arentson E, Kingsley PD, Palis J, Choi K. Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression. Development, 2002, 129(23): 5511-5520.[18] Huber TL, Kouskoff V, Fehling HJ, Palis J, Keller G. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature, 2004, 432(7017): 625-630.[19] Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomson JA. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci USA, 2001, 98(19): 10716-10721.[20] Levenberg S, Golub JS, Amit M, Itskovitz-Eldor J, Langer R. Endothelial |