遗传 ›› 2013, Vol. 35 ›› Issue (5): 595-598.doi: 10.3724/SP.J.1005.2013.00595

• 综述 • 上一篇    下一篇

CGI-58在动物脂类代谢中的作用

谢宇潇, 高士争, 赵素梅   

  1. 云南农业大学, 云南省动物营养与饲料重点实验室, 昆明 650201
  • 收稿日期:2012-09-23 修回日期:2012-11-19 出版日期:2013-05-20 发布日期:2013-05-25
  • 通讯作者: 赵素梅 E-mail:zhaosm2009@126.com
  • 基金资助:

    国家自然科学基金项目(编号:30660132, 31060331)和云南省自然科学基金项目(编号:2009CD056)资助

Function of comparative gene identification-58 (CGI-58) on lipid metabolism in animals

XIE Yu-Xiao, GAO Shi-Zheng, ZHAO Su-Mei   

  1. Yunnan Key Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, Kunming 650201, China
  • Received:2012-09-23 Revised:2012-11-19 Online:2013-05-20 Published:2013-05-25

摘要: 细胞中脂滴(Lipid droplets, LDs)表面存在多个调控脂肪储存和分解的蛋白, 这些蛋白对机体的脂肪代谢起着很重要的调控作用。CGI-58(Comparative gene identification-58)分布在LDs表面, 属于α/β水解酶折叠家族, 是脂肪甘油三酯脂肪酶(Adipose triglyceride lipase, ATGL)和依赖酰基辅酶A溶血磷脂酸酰基转移酶(Lysophosphatidic acid acyltransferase, LPAAT)的激活剂。在脂肪分解过程中, CGI-58结合PAT蛋白家族成员之一的脂滴包被蛋白(Perlipin)和ATGL, 促进脂肪分解, 同时CGI-58对ATGL的激活功能受脂滴包被蛋白家族成员间蛋白质与蛋白质相互作用的影响。文章结合国内外研究热点, 针对CGI-58在动物脂类代谢中的作用进行了综述。

关键词: 脂肪甘油三酯脂肪酶, 脂滴包被蛋白, 溶血磷脂酸酰基转移酶, 脂滴, 脂类代谢

Abstract: There are some proteins on the surfaces of lipid droplets (LDs) in the cells which could regulate the lipogenesis and lipolysis, and play an important role in lipid metabolism of the whole body. Comparative gene identification-58 (CGI-58), distributing predominantly on the surface of LDs, which is a member of the α/β-hydrolase folding family and an activator of adipose triglyceride lipase (ATGL) and acyl-CoA-dependent lysophosphatidic acid acyltransfer (LPAAT). CGI-58 promotes lipolysis by combining with perilipin which is a member of the PAT family and ATGL. At the same time, the function of CGI-58 to activate ATGL is influenced by protein-protein interaction with the members of the perilipin family. This paper reviews the CGI-58 function in lipid metabolism of animals considering the hot topics.

Key words: adipose triglyceride lipase (ATGL), comparative gene identification-58 (CGI-58), lysophosphatidic acid acyltransferase (LPAAT), lipid droplets (LDs), lipid metabolism