遗传 ›› 2014, Vol. 36 ›› Issue (6): 547-551.doi: 10.3724/SP.J.1005.2014.0547

• 综述 • 上一篇    下一篇

SNARE蛋白调控细胞自噬的分子机制

陈元渊, 陈红岩, 卢大儒   

  1. 复旦大学生命科学院, 遗传学国家重点实验室, 上海 200433
  • 收稿日期:2013-12-09 修回日期:2014-01-14 出版日期:2014-06-20 发布日期:2014-05-28
  • 通讯作者: 卢大儒,博士,教授,研究方向:遗传学。E-mail:drlu@fudan.edu.cn E-mail:xoocharles@163.com
  • 作者简介:陈元渊,博士研究生,研究方向:分子遗传学。E-mail:xoocharles@163.com
  • 基金资助:

    国家自然科学基金项目(编号:81372706, 81372235 资助)

Molecular mechanisms of SNARE proteins in regulating autophagy

Yuanyuan Chen, Hongyan Chen, Daru Lu   

  1. State Key Laboratory of Genetics, School of Life Science, Fudan University, Shanghai 200433, China
  • Received:2013-12-09 Revised:2014-01-14 Online:2014-06-20 Published:2014-05-28

摘要:

细胞自噬是细胞在面对内外部环境压力的情况下, 为了自身的稳定而采取的一种降解内部及外来入侵物质的机制。SNARE(Soluble N-ethylmaleimide-sensitive factor attachment protein receptors)假说指出SNARE蛋白在细胞物质运输以及特异性膜融合过程中具有重要作用, 揭示了细胞正常生理活动有序进行的分子机制。由于细胞自噬涉及从自噬体的形成到自噬体溶酶体的融合等诸多膜融合的过程, 因此, 文章对近年来SNARE蛋白在调控细胞自噬过程的研究进展进行了综述。

关键词: 细胞自噬, SNARE假说

Abstract:

Autophagy is a self-protective mechanism that degrades inner and outer invaded substances to sustain self-maintenance. SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors) hypothesis suggests important roles of SNARE proteins in the cellular activities of substance transport and specific membrane fusion, unveiling the molecular mechanisms of normal and physiological activities within a cell. Since autophagy involves membrane fusions from the birth of autophagosomes to the formation of autolysosomes, we review recent research progress on the roles of SNARE proteins in regulating autophagy.

Key words: autophagy, SNARE hypothesis