Lipin家族研究进展

doi:10.3724/SP.J.1005.2010.00981

遗传 ›› 2010, Vol. 32 ›› Issue (10): 981-993.doi: 10.3724/SP.J.1005.2010.00981

Lipin家族研究进展

唐胜球¹, 江青艳², 杨楚芬³, 邹晓庭⁴, 董小英¹

1. 韶关学院英东生物工程学院, 韶关 512005;
2. 华南农业大学动科院, 广州510642;
3. 广东工业大学轻工化工学院, 广州510006;
4. 浙江大学饲料研究所, 杭州310029

收稿日期:2010-01-06 修回日期:2010-04-08 出版日期:2010-10-20 发布日期:2010-10-20
通讯作者: 董小英 E-mail:dongcathy@163.com
基金资助:
韶关市科技局重点科研项目(编号：313-140348)和韶关学院重点科研课题资助项目(编号：2008-182)资助

Research and development of Lipin family

TANG Sheng-Qiu¹, JIANG Qing-Yan², YANG Chu-Fen³, ZOU Xiao-Ting⁴, DONG Xiao-Ying¹

1. College of Yingdong Bioengineering, Shaoguan University, Shaoguan 512005, China;
2. College of Animal Science, South China Agricultural University, Guangzhou 510642, China;
3. Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;
4. Institute of Feed Science, Zhejiang University, Hangzhou 310029, China

Received:2010-01-06 Revised:2010-04-08 Online:2010-10-20 Published:2010-10-20
Contact: DONG Xiao-Ying E-mail:dongcathy@163.com

摘要/Abstract

摘要： Lipin家族主要包括Lipin 1、Lipin 2与Lipin 3等成员, 是第一个能够双向调控机体脂类代谢的关键调节酶, 不但在脂肪代谢中起调节作用, 还在保持正常的外周神经功能、肝脏脂蛋白分泌、细胞形态、生殖性能及能量稳态等方面发挥着重要的生理功能。Lipin家族基因表达的轻微变异可能与艾滋病、胰岛素抵抗、肥胖症、糖尿病以及代谢综合征中的其他疾病相关, 并有可能成为上述临床疾病治疗的新靶点。文章就Lipin的发现、结构特点、表达与调控、生理功能及其与临床疾病的联系等研究成果进行概述。

关键词: Lipin, 脂类代谢, 生理功能, 临床疾病

Abstract: Lipin family including at least three members Lipin 1, Lipin 2, and Lipin 3 is a critical regulatory enzyme identified recently, which plays dual roles in lipid metabolisms. Lipin family has physiological effects not only on regulating lipid metabalism, but also on maintaining normal peripheral nervous functions, liver lipoprotein secretion, cell morphous, reproductive functions, and energy homeostasis. Since mutations in Lipin gene express may be associated with AIDS, insulin resistance, obesity, diabetes mellitus, and the other diseases of metabolic syndrome, Lipin may be a new useful target in treatment of above-mentioned clinical-related diseases. In this article, we focused on discovery, construction features, expression, regulatory mechanism, and biological functions of Lipin, as well as its correlation research with clinical-related diseases.

Key words: biological function, clinical-related diseases, lipin, lipid metabolism

唐胜球，江青艳，杨楚芬，邹晓庭，董小英. Lipin家族研究进展[J]. 遗传, 2010, 32(10): 981-993.

TANG Qing-Qiu, JIANG Jing-Yan, YANG Chu-Fen, JU Xiao-Ting, DONG Xiao-Yang. Research and development of Lipin family[J]. HEREDITAS, 2010, 32(10): 981-993.

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Lipin家族研究进展

Research and development of Lipin family

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