DNA甲基化修饰对血管疾病稳态失衡的影响

doi:10.16288/j.yczz.14-327

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HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (3): 221-232.doi: 10.16288/j.yczz.14-327

• Reviews • Next Articles

The effects of DNA methylation on the homeostasis in vascular diseases

Xiaoying Chen, Huadan Ye, Qingxiao Hong, Annan Zhou, Linlin Tang, Shiwei Duan

Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China

Received:2014-09-29 Revised:2014-12-18 Online:2015-03-20 Published:2015-02-10

Abstract

Abstract: Homeostasis is fundamental to maintain normal physiological functions in our body. Internal and external physical, chemical and biologial changes can cause dysregulation of vascular homeostasis, which is closely associated with the homeostasis of oxygen supply, blood transportation and lipid metabolism. Subsequent epigenetic modifications are able to lead to abnormal structures and function of vessels. DNA methylation has been shown to play a vital role in the development of vascular diseases. In addition, 5-hydroxymethylcytosine (5hmC) and N⁶-methyladenine (m⁶A), as new epigenetic modifications, provide additional clues for vascular diseases. In this review, we summarize the effects of DNA methylation on the homeostasis dysregulation in the vascular diseases.

Key words: DNA methylation, vascular homeostasis, 5hmC, m6A

Xiaoying Chen, Huadan Ye, Qingxiao Hong, Annan Zhou, Linlin Tang, Shiwei Duan. The effects of DNA methylation on the homeostasis in vascular diseases[J]. HEREDITAS(Beijing), 2015, 37(3): 221-232.

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The effects of DNA methylation on the homeostasis in vascular diseases

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