同卵双胞胎在复杂性状DNA甲基化调控机制研究中的应用

doi:10.16288/j.yczz.16-238

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Hereditas(Beijing) ›› 2016, Vol. 38 ›› Issue (12): 1043-1055.doi: 10.16288/j.yczz.16-238

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Research progress of regulatory mechanism of DNA methylation in complex traits using monozygotic twins

Shuli Liu, Shengli Zhang, Ying Yu

College of Animal Science and Technology, China Agricultural University, Beijing 100193, China

Received:2016-07-04 Revised:2016-11-13 Online:2016-12-20 Published:2016-11-17
Supported by:
Supported by the National Natural Science Foundation of China (No. 31272420), Modern Agro-industry Technology Research System (No. CARS-37-04B) and the Program for Changjiang Scholar and Innovation Research Team in University (No. IRT1191)

Abstract

Abstract: Coming from a single zygote, monozygotic (MZ) twins share nearly all of their genetic materials and are almost strikingly similar in appearance. Yet they are often discordant for important phenotypes including complex diseases. The study of discordant MZ twins allows us to understand the role of epigenetics in complex traits by controlling many potential confounders, such as genetic factors, maternal effects, age and sex. As we know, DNA methylation is the most stable epigenetic modification. In human, many causal genes, regulating disease status by DNA methylation modification in imprinting disorders, psychological disorders, autoimmune diseases and cancers, have been discovered, which provides a foundation for studying epigenetic regulation of diseases and application of epigenetic drugs. This article reviews the latest findings on DNA methylation status, estimates of DNA methylation heritability as well as studies of DNA methylation regulation in complex traits using MZ twins, in order to provide reference for research on epigenetic modification in complex traits.

Key words: monozygotic twins, DNA methylation, complex traits, heritability of DNA methylation

Shuli Liu, Shengli Zhang, Ying Yu. Research progress of regulatory mechanism of DNA methylation in complex traits using monozygotic twins[J]. Hereditas(Beijing), 2016, 38(12): 1043-1055.

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Research progress of regulatory mechanism of DNA methylation in complex traits using monozygotic twins

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