失巢凋亡相关转录特征预测肝癌预后和免疫微环境的潜在价值

doi:10.16288/j.yczz.25-007

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (7): 768-785.doi: 10.16288/j.yczz.25-007

• Research Article • Previous Articles Next Articles

Potential value of anoikis transcriptional signatures in predicting prognosis and immune microenvironment in hepatocellular carcinoma

Furong Cheng¹^,²(), Wenyu Song², Pengbo Cao², Gangqiao Zhou¹^,²()

1. College of Life Science, Hebei University, Baoding 071002, China
2. State Key Lab of Medical Proteomics, National Center for Protein Sciences at Beijing, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China

Received:2025-01-06 Revised:2025-03-17 Online:2025-03-26 Published:2025-03-26
Contact: Gangqiao Zhou E-mail:1578877852@qq.com;zhougq114@126.com
Supported by:
National Natural Science Foundation of China(82002573);National Natural Science Foundation of China(82172707);National Key Research and Development Program of China(2017YFA0504301)

Abstract

Abstract:

Resistance to anoikis, a crucial factor in cancer cell survival, drives the development and progression of numerous malignancies. Hepatocellular carcinoma (HCC) is a malignant liver tumor characterized by high rates of recurrence and metastasis. However, the role of anoikis in HCC remains poorly understood. In this study, we identify 74 anoikis-related genes (ARGs) differentially expressed in HCC using the transcriptional data from The Cancer Genome Atlas (TCGA). Then, we develop a prognostic model incorporating 9 of these genes through LASSO-Cox regression analysis, and confirm the model’s independent prognostic significance for overall survival in HCC patients by using multivariable Cox proportional hazards analysis. Furthermore, we observe significant enrichment of activated proliferation-related pathways, increased infiltration of immunosuppressive cells and resistance to anti-PD-L1 therapy in the high-risk group defined by this model. These findings suggest that the ARG model may serve as a novel prognostic indicator for HCC patients and underscore the critical role of anoikis in HCC progression.

Key words: hepatocellular carcinoma, anoikis, prognostic model, immune microenvironment

Furong Cheng, Wenyu Song, Pengbo Cao, Gangqiao Zhou. Potential value of anoikis transcriptional signatures in predicting prognosis and immune microenvironment in hepatocellular carcinoma[J]. Hereditas(Beijing), 2025, 47(7): 768-785.

Figures/Tables 8

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Potential value of anoikis transcriptional signatures in predicting prognosis and immune microenvironment in hepatocellular carcinoma

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