赖氨酸甲基转移酶PR-SET7及其生物学功能

doi:10.3724/SP.J.1005.2013.00241

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HEREDITAS ›› 2013, Vol. 35 ›› Issue (3): 241-254.doi: 10.3724/SP.J.1005.2013.00241

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The biological functions of lysine methyltransferase PR-SET7

LIANG Xin-Quan , DU Yi-Peng , WANG Dong-Lai , YANG Yang

School of Basic Medical Sciences, Peking University, Beijing 100191, China

Received:2012-05-16 Revised:2012-07-27 Online:2013-03-20 Published:2013-03-25

Abstract

Abstract: PR-SET7 (also named SET8 or KMT5a) is a sole lysine methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20me1) in higher eukaryotes. The abundance of PR-SET7 is dynamically mediated by the distinct E3 ubiquitin ligases in different cell cycle phases. PR-SET7 is closely related to the regulation of cell proliferation, and the H4K20me1 catalyzed by PR-SET7 has been implicated in regulating the diverse biological processes, including DNA replication, chromosome condensation and the activation of DNA replication checkpoints. Loss of PR-SET7 results in mas-sive DNA damage, cell cycle arrest and induction of apoptosis. In addition, PR-SET7 involves in regulating the transcrip-tion of several genes, such as ERa, Wnt and p53. PR-SET7 is also essential for individual development and partici-pates in the formation of genomic imprinting. Moreover, PR-SET7 has been reported to promote tumorigenesis and metastasis, suggesting that PR-SET7 may be a potential target for cancer treatment. In this review, we focus on analyzing the structure of PR-SET7 and factors influencing histone modification on regulation of PR-SET7, and discuss the mechanisms by which PR-SET7 modulates cell-cycle progression, gene transcription, individual development and tumorigenesis.

Key words: H4K20, monomethylation, cell cycle, gene transcription, PR-SET7

LIANG Xin-Quan, DU Yi-Peng, WANG Dong-Lai, YANG Yang. The biological functions of lysine methyltransferase PR-SET7[J]. HEREDITAS, 2013, 35(3): 241-254.

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