视网膜母细胞瘤基因1(RB1)研究进展

doi:10.3724/SP.J.1005.2010.01097

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (11): 1097-1104.doi: 10.3724/SP.J.1005.2010.01097

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Research advances on RB1 gene

LIU Shuang-Hu, WANG Shou-Zhi, ZHANG Hui, LI Hui

College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China

Received:2010-04-07 Revised:2010-05-23 Online:2010-11-20 Published:2010-11-25
Contact: LI Hui E-mail:lihui@neau.edu.cn

Abstract

Abstract: The retinoblastoma1 (RB1) gene is the first cloned tumor suppressor gene. As a negative regulator of the cell cycle, RB1 gene could maintain a balance between cell growth and development through binding to transcription factors and regulating the expression of genes involved in cell proliferation and differentiation. Thus, it is involved in cell cycle, cell senescence, growth arrest, apoptosis and differentiation. This review summarizes recent advances on the structure, expression, and function of RB1 gene.

Key words: cell cycle, differentiation, growth arrest, RB1 gene, structure, expression

LIU Shuang-Hu, WANG Shou-Zhi, ZHANG Hui, LI Hui. Research advances on RB1 gene[J]. HEREDITAS, 2010, 32(11): 1097-1104.

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Research advances on RB1 gene

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