CRISPR/Cas9基因组编辑技术在癌症研究中的应用

doi:10.16288/j.yczz.15-252

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HEREDITAS(Beijing) ›› 2016, Vol. 38 ›› Issue (1): 1-8.doi: 10.16288/j.yczz.15-252

• Reviews • Next Articles

The application of CRISPR/Cas9 genome editing technology in cancer research

Dayong Wang^{1, 2, 3}, Ning Ma^{1, 2, 3}, Yang Hui^{1, 2, 3}, Xu Gao^{1, 2, 3}

1. Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150086, China;
2. Translational Medicine Research and Cooperation Center of Northern China, Harbin Medical University, Harbin 150086, China;
3. Heilongjiang Academy of Medical Sciences, Harbin 150086, China

Received:2015-08-31 Revised:2015-11-20 Online:2016-01-20 Published:2016-01-20
Supported by:
[Supported by the National Natural Science Foundation of China (Nos; 81270511, 81200827)]

Abstract

Abstract: The CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein-9 nuclease) genome editing technology has become more and more popular in gene editing because of its simple design and easy operation. Using the CRISPR/Cas9 system, researchers can perform site-directed genome modification at the base level. Moreover, it has been widely used in genome editing in multiple species and related cancer research. In this review, we summarize the application of the CRISPR/Cas9 system in cancer research based on the latest research progresses as well as our understanding of cancer research and genome editing techniques.

Key words: CRISPR, CRISPR/Cas9, gene editing, cancer

Dayong Wang, Ning Ma, Yang Hui, Xu Gao. The application of CRISPR/Cas9 genome editing technology in cancer research[J]. HEREDITAS(Beijing), 2016, 38(1): 1-8.

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The application of CRISPR/Cas9 genome editing technology in cancer research

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