牛POMC基因多态性及其与南阳牛生长性状的相关分析

doi:10.3724/SP.J.1005.2009.01.002

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HEREDITAS ›› 2009, Vol. 31 ›› Issue (12): 1221-1225.doi: 10.3724/SP.J.1005.2009.01.002

The polymorphism of bovine POMC gene and its association with the growth traits of Nanyang cattle

ZHANG Chun-Lei¹, WANG Yan-Hong¹, CHEN Hong¹, LEI Chu-Zhao², FANG Xing-Tang¹, WANG Ju-Qiang³, MA Gui-Bian⁴, NIU Hui³, XIAO Jie³

1. Institute of Cellular and Molecular Biology, Xuzhou Normal University, Xuzhou 221116, China; 2. College of Animal Science and Technology, Northwest A& F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, 712100, China; 3. Research Center of Beef Engineering and Technology in Henan, Zhengzhou, 450003, China; 4. Pingdingshan Animal Husbandry Station of Henan Province, Pingdingshan, 467001, China

Received:2009-08-16 Revised:2009-09-30 Online:2009-12-10 Published:2009-12-10
Contact: CHEN Hong E-mail:chenhong1212@263.net

Abstract

Abstract:

Pro-opiomelanocortin (POMC) plays an important role on animal ingestive behavior and energy homeostasis. Genetic variation of POMC was detected by PCR-SSCP and DNA sequencing techniques in 480 individuals from seven cattle breeds (i.e., Qinchuan, Nanyang, Jiaxian Red cattle, Jinnan, Luxi, Angus, and Chinese Holstein), and association analyses were carried out to evaluate the effects of genotypes of the candidate genes on growth traits in Nanyang cattle. Three SNPs (811845 C>T, 811821 T>C and 811797 A>G, ref. NW_928357) in linkage were detected in P3 locus, which were located at the 3’ flanking region of bovine POMC gene. The body weight at 6-month-old and the average daily gain of 0~6-month-old were higher in Nanyang cattle with the genotype BB than with the genotype AA (P<0.05).

Key words: cattle, POMC gene, SNP, growth trait, body weight

ZHANG Chun-Lei, WANG Yan-Gong, CHEN Hong, LEI Chu-Chao, FANG Xin-Tang, WANG Ji-Jiang, MA Gui-Bian, NIU Hui, XIAO Jie. The polymorphism of bovine POMC gene and its association with the growth traits of Nanyang cattle[J]. HEREDITAS, 2009, 31(12): 1221-1225.

References 12

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The polymorphism of bovine POMC gene and its association with the growth traits of Nanyang cattle

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