组蛋白泛素化修饰及其在DNA损伤应答中的作用

doi:10.16288/j.yczz.18-112

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (1): 29-40.doi: 10.16288/j.yczz.18-112

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Histone ubiquitylation and its roles in DNA damage response

Qingyi Zhang¹,Yingzi Zhang²,Kai Shen¹,Shuyu Zhang²,Jianping Cao²

^1. The First Clinical Medical School, Soochow University, Suzhou 215123, China
^2. School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Science, Soochow University, Suzhou 215123, China

Received:2018-07-10 Revised:2018-09-04 Online:2019-01-20 Published:2018-10-19
Supported by:
[Supported by the National Students’ Platform for Innovation and Entrepreneurship Training Program (Nos. 201610285039Z, 201610285045Z)]

Abstract

Abstract:

Ubiquitylation is an essential type of protein post-translational modifications (PTMs) in eukaryotes, which mediates various biological processes by regulating the subcellular localization, activity, and stability of proteins. Histones, as the main protein ingredients of chromatin, are closely coupled with DNA activities such as replication, transcription and repair, and therefore are the hotspots of PTMs. After DNA damage, histone ubiquitylations are involved in DNA damage response (DDR) by regulating nucleosome structure, activating cell cycle checkpoints, remodeling the nucleosome, and the recruitment and assembly of repair factors. Meanwhile, histone ubiquitylations can also crosstalk with other types of PTMs to regulate DDR processes. In this review, we summarize how the site-specific histone ubiquitylation forms signal network and contributes to DDR, which may shed light on the further study of how histone codes formed by histone PTMs affect the entire DDR processes.

Key words: histone, ubiquitylation, DNA damage response (DDR), crosstalk

Qingyi Zhang, Yingzi Zhang, Kai Shen, Shuyu Zhang, Jianping Cao. Histone ubiquitylation and its roles in DNA damage response[J]. Hereditas(Beijing), 2019, 41(1): 29-40.

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