遗传 ›› 2016, Vol. 38 ›› Issue (4): 275-288.doi: 10.16288/j.yczz.16-049
• 特邀综述 • 下一篇
张笑, 贾桂芳
收稿日期:2016-02-01
修回日期:2016-03-04
出版日期:2016-04-20
发布日期:2016-04-20
通讯作者:
贾桂芳,博士,副研究员,研究方向：RNA表观遗传学。E-mail: guifangjia@pku.edu.cn
作者简介:张笑,博士研究生,研究方向：化学生物学。E-mail: zhangxiaoxiao@pku.edu.cn
基金资助:Xiao Zhang, Guifang Jia
Received:2016-02-01
Revised:2016-03-04
Online:2016-04-20
Published:2016-04-20
摘要： N6-甲基腺嘌呤(N6-methyladenosine, m6A)是真核生物信使RNA(Messenger RNA, mRNA)上含量最多的化学修饰之一。类似于DNA和组蛋白化学修饰,m6A修饰也同样是动态可逆的,可在时间和空间上被甲基转移酶和去甲基酶调控。哺乳动物体内m6A甲基转移酶复合物中有一部分成分已被解析,主要有METTL3 (Methyltransferase-like protein 3)、METTL14 (Methyltransferase-like protein 14)和WTAP (Wilms tumor 1-associating protein)。m6A去甲基酶肥胖蛋白FTO (Fat mass and obesity associated protein)和ALKBH5 (AlkB homolog 5)依赖α-酮戊二酸(α-Ketoglutaric acid, α-KG)和Fe(Ⅱ)对m6A进行氧化去甲基化反应。m6A在生物体内由m6A结合蛋白识别,并介导其行使功能。目前发现的m6A结合蛋白有YTH结构域蛋白YTHDF1 (YTH domain-containing family protein 1)、YTHDF2 (YTH domain-containing family protein 2)、YTHDC1 (YTH domain-containing protein 1)和核内HNRNPA2B1 (Heterogeneous nuclear ribonucleoproteins A2B1)。本文综述了m6A的分布和相关蛋白介导的m6A功能研究,以期全面理解m6A这一RNA表观遗传新修饰在生命进程中的重要调控作用。
张笑, 贾桂芳. RNA表观遗传修饰：N6-甲基腺嘌呤[J]. 遗传, 2016, 38(4): 275-288.
Xiao Zhang, Guifang Jia. RNA epigenetic modification: N6-methyladenosine[J]. HEREDITAS(Beijing), 2016, 38(4): 275-288.
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