2015年中国动物遗传学研究领域若干重要进展

doi:10.16288/j.yczz.16-205

遗传 ›› 2016, Vol. 38 ›› Issue (6): 467-507.doi: 10.16288/j.yczz.16-205

• 特邀综述 • 下一篇

2015年中国动物遗传学研究领域若干重要进展

张博¹, 陈晓芳², 黄勋², 杨晓³

1. 北京大学生命科学学院,细胞增殖与分化教育部重点实验室,北京 100871;
2. 中国科学院遗传与发育生物学研究所,北京 100101;
3. 军事医学科学院生物工程研究所,发育和疾病遗传学研究室,北京 100071

收稿日期:2016-04-25 修回日期:2016-06-06 出版日期:2016-06-20 发布日期:2016-06-08
通讯作者: 张博,教授,博士生导师,研究方向：斑马鱼遗传发育。E-mail: bzhang@pku.edu.cn
黄勋,研究员,博士生导师,研究方向：脂肪代谢调控、发育与脂肪代谢疾病的分子机制。E-mail: xhuang@genetics.ac.cn
杨晓,研究员,博士生导师,研究方向：组织稳态维持和疾病的分子机制。E-mail: yangx@bmi.ac.cn

Research advances on animal genetics in China in 2015

Bo Zhang¹, Xiaofang Chen², Xun Huang², Xiao Yang³

1. Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, College of Life Sciences, Peiking University, Beijing 100871, China;
2. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
3. Genetic Laboratory of Development and Disease, Institute of Biotechnology, Beijing 100071, China

Received:2016-04-25 Revised:2016-06-06 Online:2016-06-20 Published:2016-06-08

摘要/Abstract

摘要： 2015年中国科学家在动物遗传学领域的研究成果斐然。据不完全统计,2015年围绕线虫(Caenorhabditis elegans)、果蝇(Drosophila melanogaster)、斑马鱼(Danio rerio)、爪蛙(Xenopus)和小鼠(Mus musculus)等5个模式动物发表的论文中涉及中国的论文数约占总论文数的1/5,众多具有原创性的研究成果在国际高影响力的期刊上发表。例如：首次鉴定出潜在的磁受体MagR,为磁感应遗传与分子机制的研究带来了重大突破;揭示了褐飞虱(Nilaparvata lugens)翅多型性的遗传基础;首次证明在果蝇基因组中存在腺嘌呤的N⁶-甲基化;揭示了哺乳动物树突棘修剪与成熟的新的分子机制;发现CRTC2介导的信号通路调控肝脏脂代谢;发现神经递质多巴胺能够调节炎症反应;发现Gasdermin蛋白家族具有诱导细胞焦亡的功能;发现小清蛋白阳性的兴奋性视觉通路能够触发小鼠的恐惧反应等。2015年中国科学家在TALEN和CRISPR/Cas基因组靶向编辑技术领域同样做出了重要贡献。据不完全统计,其中涉及中国的论文占比多于1/5,覆盖了从线虫到灵长类的多种动物、多种基因组修饰方法,并且在世界上首次成功编辑了人类早期胚胎。中国在基因组序列测定与分析研究领域一如既往地保持世界领先,2015年中国科学家在动物基因组方面绘制了家鹅(Anser cygnoides)、壁虎(Gekko japonicus)、草鱼(Ctenopharyngodon idellus)和大黄鱼(Larimichthys crocea)的基因组序列图谱,完成了69头中国地方猪(Sus scrofa)的基因组重测序,分别分析了这些动物所独有的生理病理特征以及环境适应能力的遗传基础。本文首次尝试对以中国本土科研团队为主的动物遗传学领域若干重要科研进展进行年度回顾,并选取若干重点论文进行简要介绍,以彰显中国科学家在动物遗传学领域的科研实力和重要贡献。

关键词: 中国, 动物遗传学, 研究进展, 2015年

Abstract: Chinese scientists have made significant achievements in the field of animal genetics in 2015. Incomplete statistics show that among all the publications of 2015 involving nematode (Caenorhabditis elegans), fly (Drosophila melanogaster), zebrafish (Danio rerio), African clawed frog (Xenopus) or mice (Mus musculus), about 1/5 publications are from China. Many innovative studies were published in high-impact international academic journals by Chinese scientists, including the identification of a putative magnetic receptor MagR, the genetic basis for the regulation of wing polyphenism in the insect brown planthopper (Nilaparvata lugens), DNA N⁶-methyladenine (6mA) modification in the Drosophila genome, a novel molecular mechanism regarding the dendritic spine pruning and maturation in the mammals, the mechanism for the CREB coactivator CRTC2 in the regulation of hepatic lipid metabolism, the control of systemic inflammation by neurotransmitter dopamine, the role of Gasdermin protein family in triggering pyroptosis, a parvalbumin-positive excitatory visual pathway to trigger fear responses in mice, etc. Chinese scientists have also made important contributions in genome editing via TALEN or CRISPR/Cas system. According to incomplete statistics, more than 1/5 of the publications related to genome editing in 2015 are from China, where a variety of animals with different approaches were targeted, ranging from the worm to primates. Particularly, CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes was successfully achieved for the first time. China has been one of the leading countries in genome sequencing in recent years, and Chinese scientists reported the sequence and annotation of the genomes of several important animal species in 2015, including goose (Anser cygnoides), Schlegel’s Japanese Gecko (Gekko japonicus), grass carp (Ctenopharyngodon idellus), large yellow croaker (Larimichthys crocea) and pig (Sus scrofa). They further analyzed the genome-wide genetic basis of the species-specific physiological and pathological characteristics as well as their adaptation to environmental conditions. In this review, we make a first attempt to summarize the research advances on animal genetics in China in 2015, with an emphasis on the achievements led by Chinese scientists and carried out in Chinese institutions. We will briefly discuss the significance of their research and contributions of Chinese scientists in animal genetics.

Key words: China, animal genetics, research advances, 2015

张博, 陈晓芳, 黄勋, 杨晓. 2015年中国动物遗传学研究领域若干重要进展[J]. 遗传, 2016, 38(6): 467-507.

Bo Zhang, Xiaofang Chen, Xun Huang, Xiao Yang. Research advances on animal genetics in China in 2015[J]. HEREDITAS(Beijing), 2016, 38(6): 467-507.

参考文献

[1] Chen YC, Cui YQ, Shen B, Niu YY, Zhao XY, Wang L, Wang JY, Li W, Zhou Q, Ji WZ, Sha JH, Huang XX. Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys. Cell Res , 2015, 25(2): 262-265.
[2] Wan HF, Feng CJ, Teng F, Yang SH, Hu BY, Niu YY, Xiang AP, Fang WZ, Ji WZ, Li W, Zhao XY, Zhou Q. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res , 2015, 25(2): 258-261.
[3] Kang Y, Zheng B, Shen B, Chen YC, Wang L, Wang JY, Niu YY, Cui YQ, Zhou JK, Wang H, Guo XJ, Hu B, Zhou Q, Sha JH, Ji WZ, Huang XX. CRISPR/Cas9- mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Hum Mol Genet , 2015, 24(25): 7255- 7264.
[4] Chen YC, Zheng YH, Kang Y, Yang WL, Niu YY, Guo XY, Tu ZC, Si CY, Wang H, Xing RX, Pu XQ, Yang SH, Li SH, Ji WZ, Li XJ. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Hum Mol Genet , 2015, 24(13): 3764-3774.
[5] Chen YC, Niu YY, Li YJ, Ai ZY, Kang Y, Shi H, Xiang Z, Yang ZH, Tan T, Si W, Li W, Xia XS, Zhou Q, Ji WZ, Li TQ. Generation of Cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell Stem Cell , 2015, 17(1): 116-124.
[6] Wu HB, Wang YS, Zhang Y, Yang MQ, Lv JX, Liu J, Zhang Y. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci USA , 2015, 112(13): E1530-E1539.
[7] Zou QJ, Wang XM, Liu YZ, Ouyang Z, Long HB, Wei S, Xin JG, Zhao BT, Lai SS, Shen J, Ni QC, Yang HQ, Zhong HL, Li L, Hu MH, Zhang QJ, Zhou ZD, He JX, Yan QM, Fan NN, Zhao Y, Liu ZM, Guo L, Huang J, Zhang GG, Ying J, Lai LX, Gao X. Generation of gene-target dogs using CRISPR/Cas9 system. J Mol Cell Biol , 2015, 7(6): 580-583.
[8] Kou ZH, Wu Q, Kou XC, Yin CH, Wang H, Zuo ZT, Zhuo Y, Chen A, Gao SR, Wang XQ. CRISPR/Cas9- mediated genome engineering of the ferret. Cell Res , 2015, 25(12): 1372-1375.
[9] Zhong CQ, Yin Q, Xie ZF, Bai MZ, Dong R, Tang W, Xing YH, Zhang HL, Yang SM, Chen LL, Bartolomei MS, Ferguson-Smith A, Li DS, Yang L, Wu YX, Li JS. CRISPR-Cas9-mediated genetic screening in mice with haploid embryonic stem cells carrying a guide RNA library. Cell Stem Cell , 2015, 17(2): 221-232.
[10] Wu YX, Zhou H, Fan XY, Zhang Y, Zhang M, Wang YH, Xie ZF, Bai MZ, Yin Q, Liang D, Tang W, Liao JY, Zhou CK, Liu WJ, Zhu P, Guo HS, Pan H, Wu CL, Shi HJ, Wu LG, Tang FC, Li JS. Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Cell Res , 2015, 25(1): 67-79.
[11] Yuan Y, Zhou Q, Wan HF, Shen B, Wang XP, Wang M, Feng CJ, Xie MM, Gu TT, Zhou T, Fu R, Huang XX, Zhou Q, Sha JH, Zhao XY. Generation of fertile offspring from Kit w / Kit wv mice through differentiation of gene corrected nuclear transfer embryonic stem cells. Cell Res , 2015, 25(7): 851-863.
[12] Li JH, Shou J, Guo Y, Tang YX, Wu YH, Jia ZL, Zhai Y, Chen ZF, Xu Q, Wu Q. Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol , 2015, 7(4): 284-298.
[13] Li J, Zhang BB, Ren YG, Gu SY, Xiang YH, Du JL. Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/ Cas9 system. Cell Res , 2015, 25(5): 634-637.
[14] Qin W, Liang F, Feng Y, Bai HP, Yan RB, Li S, Lin S. Expansion of CRISPR/Cas9 genome targeting sites in zebrafish by Csy4-based RNA processing. Cell Res , 2015, 25(9): 1074-1077.
[15] Long LJ, Guo H, Yao D, Xiong K, Li YJ, Liu PP, Zhu ZY, Liu D. Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C . elegans and D . rerio . Cell Res , 2015, 25(5): 638-641.
[16] Du YN, Meng QZ, Zhang J, Sun M, Shen B, Jiang H, Kang NN, Gao JM, Huang XX, Liu JH. Functional annotation of cis -regulatory elements in human cells by dCas9/sgRNA. Cell Res , 2015, 25(7): 877-880.
[17] Liang PP, Xu YW, Zhang XY, Ding CH, Huang R, Zhang Z, Lv J, Xie XW, Chen YX, Li YJ, Sun Y, Bai YF, Zhou SY, Ma WB, Zhou CQ, Huang JJ. CRISPR/Cas9- mediated gene editing in human tripronuclear zygotes. Protein Cell , 2015, 6(5): 363-372.
[18] Lu LZ, Chen Y, Wang Z, Li XF, Chen WH, Tao ZR, Shen JD, Tian Y, Wang DQ, Li GQ, Chen L, Chen F, Fang DM, Yu LL, Sun YD, Ma Y, Li JJ, Wang J. The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver. Genome Biol , 2015, 16: 89.
[19] Liu Y, Zhou Q, Wang YJ, Luo LH, Yang J, Yang LF, Liu M, Li YR, Qian TM, Zheng Y, Li MY, Li J, Gu Y, Han ZJ, Xu M, Wang YJ, Zhu CL, Yu B, Yang YM, Ding F, Jiang JP, Yang HM, Gu XS. Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration. Nat Commun , 2015, 6: 10033.
[20] Ao JQ, Mu YN, Xiang LX, Fan DD, Feng MJ, Zhang SC, Shi Q, Zhu LY, Li T, Ding Y, Nie L, Li QH, Dong WR, Jiang L, Sun B, Zhang XH, Li MY, Zhang HQ, Xie SB, Zhu YB, Jiang XT, Wang XH, Mu PF, Chen W, Yue Z, Wang Z, Wang J, Shao JZ, Chen XH. Genome sequencing of the Perciform fish Larimichthys crocea provides insights into molecular and genetic mechanisms of stress adaptation. PLoS Genet , 2015, 11(4): e1005118.
[21] Wang YP, Lu Y, Zhang Y, Ning ZM, Li Y, Zhao Q, Lu HY, Huang R, Xia XQ, Feng Q, Liang XF, Liu KY, Zhang L, Lu TT, Huang T, Fan DL, Weng QJ, Zhu CR, Lu YQ, Li WJ, Wen ZR, Zhou CC, Tian QL, Kang XJ, Shi MJ, Zhang WT, Jang SH, Du FK, He S, Liao LJ, Li YM, Gui B, He HH, Ning Z, Yang C, He LB, Luo LF, Yang R, Luo Q, Liu XC, Li SS, Huang W, Xiao L, Lin HR, Han B, Zhu ZY. The draft genome of the grass carp ( Ctenopharyngodon idellus ) provides insights into its evolution and vegetarian adaptation. Nat Genet , 2015, 47(6): 625-631.
[22] Ai HS, Fang XD, Yang B, Huang ZY, Chen H, Mao LK, Zhang F, Zhang L, Cui LL, He WM, Yang J, Yao XM, Zhou LS, Han LJ, Li J, Sun SL, Xie XH, Lai BX, Su Y, Lu Y, Yang H, Huang T, Deng WJ, Nielsen R, Ren J, Huang LS. Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequencing. Nat Genet , 2015, 47(3): 217-225.
[23] Li WJ, Yi PS, Ou GS. Somatic CRISPR-Cas9-induced mutations reveal roles of embryonically essential dynein chains in Caenorhabditis elegans cilia. J Cell Biol , 2015, 208(6): 683-692.
[24] Cheng SY, Wang K, Zou W, Miao R, Huang YL, Wang HB, Wang XC. PtdIns(4,5)P 2 and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. J Cell Biol , 2015, 210(3): 485-502.
[25] Zhao XC, Yang H, Liu W, Duan XY, Shang WN, Xia DJ, Tong C. Sec22 regulates endoplasmic reticulum morphology but not autophagy and is required for eye development in Drosophila . J Biol Chem , 2015, 290(12): 7943-7951.
[26] Ge WZ, Deng QN, Guo T, Hong X, Kugler JM, Yang XH, Cohen SM. Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA. Genetics , 2015, 200(1): 255-265.
[27] Yang F, Zhao R, Fang XF, Huang HW, Xuan Y, Ma YT, Chen HY, Cai T, Qi YJ, Xi RW. The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep , 2015, 16(8): 965-974.
[28] Lu TL, Wang S, Gao Y, Mao Y, Yang ZH, Liu LP, Song XQ, Ni JQ, Xie T. COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila ovary. Development , 2015, 142(24): 4242-4252.
[29] Li CY, Kan LJ, Chen Y, Zheng XD, Li WN, Zhang WX, Cao L, Lin XH, Ji SM, Huang SJ, Zhang GQ, Liu XH, Tao Y, Wu SA, Chen DH. Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation. Cell Res , 2015, 25(10): 1152-1170.
[30] Sun J, Wei HM, Xu J, Chang JF, Yang ZH, Ren XJ, Lv WW, Liu LP, Pan LX, Wang X, Qiao HH, Zhu B, Ji JY, Yan D, Xie T, Sun FL, Ni JQ. Histone H1-mediated epigenetic regulation controls germline stem cell self- renewal by modulating H4K16 acetylation. Nat Commun , 2015, 6: 8856.
[31] Wang CH, Guo XT, Dou K, Chen HY, Xi RW. Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development , 2015, 142(19): 3321-3331.
[32] Ren WY, Zhang Y, Li M, Wu LF, Wang GL, Baeg GH, You J, Li ZH, Lin XH. Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation. PLoS Genet , 2015, 11(4): e1005180.
[33] Wang C, Zhang WX, Yin MX, Hu LX, Li PX, Xu JJ, Huang HL, Wang SM, Lu Y, Wu WQ, Ho MS, Li L, Zhao Y, Zhang L. Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nat Commun , 2015, 6: 6607.
[34] Zhang HT, Li CQ, Chen HQ, Wei CX, Dai F, Wu HG, Dui W, Deng WM, Jiao RJ. SCF Slmb E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila . Cell Res , 2015, 25(1): 93-109.
[35] Ma XJ, Chen YJ, Xu WY, Wu NN, Li MQ, Cao Y, Wu SA, Li QT, Xue L. Impaired Hippo signaling promotes Rho1-JNK-dependent growth. Proc Natl Acad Sci USA , 2015, 112(4): 1065-1070.
[36] Zhang GQ, Huang H, Liu D, Cheng Y, Liu XL, Zhang WX, Yin RC, Zhang DP, Zhang P, Liu JZ, Li CY, Liu BD, Luo YW, Zhu YX, Zhang N, He SM, He C, Wang HL, Chen DH. N 6 -methyladenine DNA modification in Drosophila . Cell , 2015, 161(4): 893-906.
[37] Yang HW, He BZ, Ma HJ, Tsaur SC, Ma CY, Wu Y, Ting CT, Zhang YE. Expression profile and gene age jointly shaped the genome-wide distribution of premature termination codons in a Drosophila melanogaster population. Mol Biol Evol , 2015, 32(1): 216-228.
[38] Bi Y, Ren XL, Yan C, Shao JF, Xie DY, Zhao ZY. A Genome-wide hybrid incompatibility landscape between Caenorhabditis briggsae and C . nigoni . PLoS Genet , 2015, 11(2): e1004993.
[39] Zhao HQ, Zhang P, Gao H, He XD, Dou YM, Huang AY, Liu XM, Ye AY, Dong MQ, Wei LP. Profiling the RNA editomes of wild-type C . elegans and ADAR mutants. Genome Res , 2015, 25(1): 66-75.
[40] Gao JL, Fan YJ, Wang XY, Zhang Y, Pu J, Li L, Shao W, Zhan S, Hao JJ, Xu YZ. A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila . Genes Dev , 2015, 29(7): 760-771.
[41] Mao H, Zhu CM, Zong DD, Weng CC, Yang XW, Huang H, Liu D, Feng XZ, Guang SH. The Nrde pathway mediates small-RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans . Curr Biol , 2015, 25(18): 2398-2403.
[42] Wu CX, Chen YJ, Wang F, Chen CY, Zhang SP, Li CJ, Li WZ, Wu SA, Xue L. Pelle modulates dFoxO-mediated cell death in Drosophila . PLoS Genet , 2015, 11(10): e1005589.
[43] Xu HJ, Xue J, Lu B, Zhang XC, Zhuo JC, He SF, Ma XF, Jiang YQ, Fan HW, Xu JY, Ye YX, Pan PL, Li Q, Bao YY, Nijhout HF, Zhang CX. Two insulin receptors determine alternative wing morphs in planthoppers. Nature , 2015, 519(7544): 464-467.
[44] Wen D, Rivera-Perez C, Abdou M, Jia QQ, He QY, Liu X, Zyaan O, Xu JJ, Bendena WG, Tobe SS, Noriega FG, Palli SR, Wang J, Li S. Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. PLoS Genet , 2015, 11(3): e1005038.
[45] Ho VWS, Wong MK, An XM, Guan DG, Shao JF, Ng HCK, Ren XL, He K, Liao JY, Ang YJ, Chen L, Huang XT, Yan B, Xia YJ, Chan LLH, Chow KL, Yan H, Zhao ZY. Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry. Mol Syst Biol , 2015, 11(6): 814.
[46] Tian XJ, Gala U, Zhang YP, Shang WN, Nagarkar Jaiswal S, di Ronza A, Jaiswal M, Yamamoto S, Sandoval H, Duraine L, Sardiello M, Sillitoe RV, Venkatachalam K, Fan HY, Bellen HJ, Tong C. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol , 2015, 13(3): e1002103.
[47] Tian D, Diao M, Jiang YX, Sun LF, Zhang Y, Chen ZC, Huang SJ, Ou GS. Anillin regulates neuronal migration and neurite growth by linking RhoG to the actin cytoskeleton. Curr Biol , 2015, 25(9): 1135-1145.
[48] Wang JB, Chitturi J, Ge QL, Laskova V, Wang W, Li X, Ding M, Zhen M, Huang X. The C . elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development , 2015, 142(8): 1447-1457.
[49] Cheng YS, Wang JM, Wang Y, Ding M. Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife , 2015, 4: e05118.
[50] Zhao GL, Wu YG, Du L, Li WH, Xiong Y, Yao AY, Wang QF, Zhang YQ. Drosophila S6 Kinase like inhibits neuromuscular junction growth by downregulating the BMP receptor thickveins. PLoS Genet , 2015, 11(3): e1004984.
[51] Guo M, Wu TH, Song YX, Ge MH, Su CM, Niu WP, Li LL, Xu ZJ, Ge CL, Al-Mhanawi MTH, Wu SP, Wu ZX. Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans . Nat Commun , 2015, 6: 5655.
[52] Luo JT, Xu ZF, Tan ZP, Zhang ZH, Ma L. Neuropeptide receptors NPR-1 and NPR-2 regulate Caenorhabditis elegans avoidance response to the plant stress hormone methyl salicylate. Genetics , 2015, 199(2): 523-531.
[53] Chun L, Gong JK, Yuan FL, Zhang B, Liu HK, Zheng TL, Yu T, Xu XZS, Liu JF. Metabotropic GABA signalling modulates longevity in C . elegans . Nat Commun , 2015, 6: 8828.
[54] Zhang Y, Li WN, Li LF, Li YB, Fu R, Zhu Y, Li J, Zhou YF, Xiong SD, Zhang HM. Structural damage in the C . elegans epidermis causes release of STA-2 and induction of an innate immune response. Immunity , 2015, 42(2): 309-320.
[55] Pan LX, Xie WB, Li KL, Yang ZH, Xu J, Zhang WH, Liu LP, Ren XJ, He ZM, Wu JY, Sun J, Wei HM, Wang DL, Xie W, Li W, Ni JQ, Sun FL. Heterochromatin remodeling by CDK12 contributes to learning in Drosophila . Proc Natl Acad Sci USA , 2015, 112(45): 13988-13993.
[56] Yang Z, Yu Y, Zhang V, Tian YJ, Qi W, Wang LM. Octopamine mediates starvation-induced hyperactivity in adult Drosophila . Proc Natl Acad Sci USA , 2015, 112(16): 5219-5224.
[57] Zhang PP, He QP, Chen DB, Liu WX, Wang L, Zhang CX, Ma DY, Li W, Liu B, Liu F. G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Res , 2015, 25(10): 1093-1107.
[58] He QP, Zhang CX, Wang L, Zhang PP, Ma DY, Lv JH, Liu F. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood , 2015, 125(7): 1098-1106.
[59] Gao L, Li DT, Ma K, Zhang WJ, Xu T, Fu C, Jing CB, Jia XE, Wu S, Sun X, Dong M, Deng M, Chen Y, Zhu WG, Peng JR, Wan FY, Zhou Y, Zon LI, Pan WJ. TopBP1 governs hematopoietic stem/progenitor cells survival in zebrafish definitive hematopoiesis. PLoS Genet , 2015, 11(7): e1005346.
[60] Jia XE, Ma K, Xu T, Gao L, Wu S, Fu C, Zhang WJ, Wang ZZ, Liu KY, Dong M, Jing CB, Ren CG, Dong ZW, Chen Y, Jin Y, Huang QH, Chang X, Deng M, Li L, Luo LF, Zhu J, Dang YJ, Chang HC, Zon LI, Zhou Y, Chen SJ, Pan WJ. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Res , 2015, 25(8): 946-962.
[61] Shi XG, He BL, Ma ACH, Guo YH, Chi YL, Man CH, Zhang WQ, Zhang YY, Wen ZL, Cheng T, Leung AYH. Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish. Blood , 2015, 125(19): 2974-2984.
[62] Wang SF, He QP, Ma DY, Xue YY, Liu F. Irf4 regulates the choice between T lymphoid-primed progenitor and myeloid lineage fates during embryogenesis. Dev Cell , 2015, 34(6): 621-631.
[63] Xu J, Zhu L, He SC, Wu Y, Jin W, Yu T, Qu JY, Wen ZL. Temporal-spatial resolution fate mapping reveals distinct origins for embryonic and adult microglia in zebrafish. Dev Cell , 2015, 34(6): 632-641.
[64] Tu T, Zhang CX, Yan HW, Luo YT, Kong RR, Wen PS, Ye ZD, Chen JN, Feng J, Liu F, Wu JY, Yan XY. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res , 2015, 25(3): 275-287.
[65] Zhou Y, Ge R, Wang R, Liu F, Huang YF, Liu H, Hao Y, Zhou Q, Wang C. UXT potentiates angiogenesis by attenuating Notch signaling. Development , 2015, 142(4): 774-786.
[66] Ma WR, Zhang J. Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death. Development , 2015, 142(4): 763-773.
[67] Xing CC, Gong B, Xue Y, Han YC, Wang YX, Meng AM, Jia SJ. TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. J Mol Cell Biol , 2015, 7(1): 48-61.
[68] Li MH, Sun YL, Zhao JE, Shi HJ, Zeng S, Ye K, Jiang DN, Zhou LY, Sun LN, Tao WJ, Nagahama Y, Kocher TD, Wang DS. A tandem duplicate of anti-Müllerian hormone with a missense SNP on the Y chromosome is essential for male sex determination in Nile Tilapia, Oreochromis niloticus . PLoS Genet , 2015, 11(11): e1005678.
[69] Gong L, Gong HJ, Pan X, Chang CQ, Ou Z, Ye SF, Yin L, Yang LN, Tao T, Zhang ZH, Liu C, Lane DP, Peng JR, Chen J. p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Res , 2015, 25(3): 351-369.
[70] Shi H, Tao T, Huang DL, Ou Z, Chen J, Peng JR. A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function. Nucleic Acids Res , 2015, 43(2): 1035-1043.
[71] Hu P, Liu ML, Zhang D, Wang JF, Niu HB, Liu YM, Wu ZC, Han BS, Zhai WY, Shen Y, Chen LB. Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish. Nucleic Acids Res , 2015, 43(19): 9198-9213.
[72] Lu L, Gao Y, Zhang Z, Cao Q, Zhang XN, Zou JH, Cao Y. Kdm2a/b Lysine demethylases regulate canonical Wnt signaling by modulating the stability of nuclear β-catenin. Dev Cell , 2015, 33(6): 660-674.
[73] Zhang XN, Gao Y, Lu L, Zhang Z, Gan SC, Xu LY, Lei AH, Cao Y. JmjC domain-containing protein 6 (Jmjd6) derepresses the transcriptional repressor transcription factor 7-like 1 (Tcf7l1) and is required for body axis patterning during Xenopus embryogenesis. J Biol Chem , 2015, 290(33): 20273-20283.
[74] Sun GN, Hu ZR, Min ZY, Yan XH, Guan ZP, Su HX, Fu Y, Ma XP, Chen YG, Zhang MQ, Tao QH, Wu W. Small C-terminal Domain Phosphatase 3 dephosphorylates the linker sites of receptor-regulated Smads (R-Smads) to ensure transforming growth factor β (TGFβ)-mediated germ layer induction in Xenopus embryos. J Biol Chem , 2015, 290(28): 17239-17249.
[75] Wang CD, Kam RKT, Shi WL, Xia Y, Chen X, Cao Y, Sun JM, Du YZ, Lu G, Chen ZJ, Chan WY, Chan SO, Deng Y, Zhao H. The proto-oncogene transcription factor Ets1 regulates neural crest development through Histone Deacetylase 1 to mediate output of bone morphogenetic protein signaling. J Biol Chem , 2015, 290(36): 21925-21938.
[76] Shi WL, Xu G, Wang CD, Sperber SM, Chen YL, Zhou Q, Deng Y, Zhao H. Heat shock 70-kDa protein 5 (Hspa5) is essential for pronephros formation by mediating retinoic acid signaling. J Biol Chem , 2015, 290(1): 577-589.
[77] Fan XY, Zhang XN, Wu XL, Guo HS, Hu YQ, Tang FC, Huang YY. Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos. Genome Biol , 2015, 16: 148.
[78] Liu N, Zhang ZQ, Wu H, Jiang YH, Meng LJ, Xiong J, Zhao ZD, Zhou XH, Li J, Li H, Zheng Y, Chen S, Cai T, Gao SR, Zhu B. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev , 2015, 29(4): 379-393.
[79] Zi ZZ, Zhang ZZ, Li QR, An WW, Zeng LY, Gao DY, Yang Y, Zhu XL, Zeng R, Shum WW, Wu JR. CCNYL1, but not CCNY, cooperates with CDK16 to regulate spermatogenesis in mouse. PLoS Genet , 2015, 11(8): e1005485.
[80] Huang B, Wang YK, Wang WH, Chen J, Lai PL, Liu ZY, Yan B, Xu S, Zhang ZM, Zeng C, Rong LM, Liu B, Cai DZ, Jin DD, Bai XC. mTORC1 prevents preosteoblast differentiation through the Notch signaling pathway. PLoS Genet , 2015, 11(8): e1005426.
[81] Zhou GD, Jiang XC, Zhang H, Lu YZ, Liu AJ, Ma XH, Yang G, Yang R, Shen HX, Zheng JM, Hu YP, Yang X, Zhang WJ, Xie ZF. Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9. Development , 2015, 142(2): 385-393.
[82] Zhu WQ, Yao X, Liang Y, Liang D, Song L, Jing NH, Li JS, Wang G. Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling. Development , 2015, 142(3): 465-476.
[83] Bian WJ, Miao WY, He SJ, Qiu ZL, Yu X. Coordinated spine pruning and maturation mediated by inter-spine competition for Cadherin/Catenin complexes. Cell , 2015, 162(4): 808-822.
[84] Liu PY, Dou XY, Liu C, Wang LB, Xing C, Peng GD, Chen J, Yu F, Qiao YB, Song L, Wu YX, Yue CM, Li JS, Han JD, Tang K, Jing NH. Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate. Nat Commun , 2015, 6: 6830.
[85] Zhang Y, Chen Q, Zhang H, Wang Q, Li R, Jin YP, Wang HB, Ma TH, Qiao J, Duan EK. Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Res , 2015, 25(1): 139- 142.
[86] Xu DQ, Wang Z, Zhang YX, Jiang W, Pan Y, Song BL, Chen Y. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun , 2015, 6: 8100.
[87] Han JB, Li EW, Chen LQ, Zhang YY, Wei FC, Liu JY, Deng HT, Wang YG. The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature , 2015, 524(7564): 243-246.
[88] Qian H, Deng X, Huang ZW, Wei J, Ding CH, Feng RX, Zeng X, Chen YX, Ding J, Qiu L, Hu ZL, Zhang X, Wang HY, Zhang JP, Xie WF. An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells. Cell Res , 2015, 25(8): 930-945.
[89] Hui XY, Gu P, Zhang JL, Nie T, Pan Y, Wu DH, Feng TS, Zhong C, Wang Y, Lam KS, Xu AM. Adiponectin enhances cold-induced browning of subcutaneous adipose tissue via promoting M2 macrophage proliferation. Cell Metab , 2015, 22(2): 279-290.
[90] Liang Y, Fu Y, Qi RM, Wang ML, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu JL, Kong W. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood , 2015, 126(7): 905-914.
[91] Cheng H, Hao S, Liu YF, Pang YK, Ma SH, Dong F, Xu J, Zheng GG, Li SG, Yuan WP, Cheng T. Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation. Blood , 2015, 126(11): 1302-1313.
[92] Xiao Q, Jiang Y, Liu QB, Yue J, Liu CY, Zhao XT, Qiao YM, Ji HB, Chen JF, Ge GX. Minor Type IV Collagen α5 Chain promotes cancer progression through discoidin domain receptor-1. PLoS Genet , 2015, 11(5): e1005249.
[93] Ma B, Chen Y, Chen L, Cheng HC, Mu CL, Li J, Gao RZ, Zhou CQ, Cao L, Liu JH, Zhu YS, Chen Q, Wu SA. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol , 2015, 17(1): 95-103.
[94] Li Y, Zheng QP, Bao CY, Li SY, Guo WJ, Zhao J, Chen D, Gu JR, He XH, Huang SL. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res , 2015, 25(8): 981-984.
[95] Chen WY, Qian W, Wu G, Chen WZ, Xian B, Chen XW, Cao YQ, Green CD, Zhao FH, Tang K, Han JD. Three- dimensional human facial morphologies as robust aging markers. Cell Res , 2015, 25(5): 574-587.
[96] Zhang BY, Zhang TT, Wang GP, Wang G, Chi WF, Jiang Q, Zhang CM. GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. PLoS Biol , 2015, 13(4): e1002129.
[97] Fu JY, Bian ML, Xin GW, Deng ZX, Luo J, Guo X, Chen H, Wang Y, Jiang Q, Zhang CM. TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux. J Cell Biol , 2015, 210(3): 373-383.
[98] Zhen YL, Li W. Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A (D251E) mutation. Autophagy , 2015, 11(9): 1608-1622.
[99] Yu C, Ji SY, Sha QQ, Sun QY, Fan HY. CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation. Nat Commun , 2015, 6: 8017.
[100] Deng L, Jiang C, Chen L, Jin JL, Wei J, Zhao LL, Chen MH, Pan WJ, Xu Y, Chu HS, Wang XB, Ge X, Li DL, Liao LJ, Liu MY, Li L, Wang P. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. Mol Cell , 2015, 58(5): 804-818.
[101] He KM, Yan XH, Li N, Dang S, Xu L, Zhao B, Li ZJ, Lv ZZ, Fang XH, Zhang YY, Chen YG. Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes. Cell Res , 2015, 25(6): 738-752.
[102] Yan YQ, Jiang W, Liu L, Wang XQ, Ding C, Tian ZG, Zhou RB. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell , 2015, 160(1-2): 62-73.
[103] Shi JJ, Zhao Y, Wang K, Shi XY, Wang Y, Huang HW, Zhuang YH, Cai T, Wang FC, Shao F. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature , 2015, 526(7575): 660-665.
[104] Li DR, Xu T, Cao Y, Wang HY, Li L, Chen S, Wang XD, Shen ZR. A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis. Proc Natl Acad Sci USA , 2015, 112(16): 5017-5022.
[105] Han CY, Nie Y, Lian H, Liu R, He F, Huang HH, Hu SS. Acute inflammation stimulates a regenerative response in the neonatal mouse heart. Cell Res , 2015, 25(10): 1137-1151.
[106] Zhao B, Qi Z, Li YH, Wang CK, Fu W, Chen YG. The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nat Commun , 2015, 6: 7166.
[107] Fu X, Xiao J, Wei YN, Li S, Liu Y, Yin J, Sun K, Sun H, Wang HT, Zhang ZK, Zhang BT, Sheng C, Wang HY, Hu P. Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion. Cell Res , 2015, 25(6): 655-673.
[108] Wang JX, Gao J, Ding SL, Wang K, Jiao JQ, Wang Y, Sun T, Zhou LY, Long B, Zhang XJ, Li Q, Liu JP, Feng C, Liu J, Gong Y, Zhou Z, Li PF. Oxidative modification of miR-184 enables it to target Bcl-xL and Bcl-w. Mol Cell , 2015, 59(1): 50-61.
[109] Shang CP, Liu ZH, Chen ZJ, Shi YC, Wang Q, Liu S, Li DP, Cao P. A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice. Science , 2015, 348(6242): 1472-1477.
[110] Zhou X, Liu F, Tian M, Xu ZJ, Liang QF, Wang CY, Li JW, Liu ZD, Tang K, He M, Yang ZG. Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb. Development , 2015, 142(9): 1593-1605.
[111] Liu X, Ma L, Li HH, Huang B, Li YX, Tao YZ, Ma L. β-Arrestin-biased signaling mediates memory reconsolidation. Proc Natl Acad Sci USA , 2015, 112(14): 4483-4488.
[112] Zhang XM, Yan XY, Zhang B, Yang Q, Ye M, Cao W, Qiang WB, Zhu LJ, Du YL, Xu XX, Wang JS, Xu F, Lu W, Qiu S, Yang W, Luo JH. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory. Cell Res , 2015, 25(7): 818-836.
[113] Qin SY, Yin H, Yang CL, Dou YF, Liu ZM, Zhang P, Yu H, Huang YL, Feng J, Hao JF, Hao J, Deng LZ, Yan XY, Dong XL, Zhao ZX, Jiang TJ, Wang HW, Luo SJ, Xie C. A magnetic protein biocompass. Nat Mater , 2016, 15(2): 217-226.

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

2015年中国动物遗传学研究领域若干重要进展

Research advances on animal genetics in China in 2015

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	张丽, 徐海冬, 冷奇颖, 刘艳芬, 赵志辉, 效梅, 吴江, 张权, 安立龙. 鸡快慢羽性状遗传学基础分析综合实验探索与实践[J]. 遗传, 2018, 40(3): 250-256.
[2]	刘莉莉, 郭爱伟, 吴培福, 陈粉粉, 杨亚晋, 张勤. 敲降VPS28基因对中国荷斯坦奶牛乳脂合成的调控[J]. 遗传, 2018, 40(12): 1092-1100.
[3]	宋述慧,滕徐菲,肖景发. 中国人群参考基因组及基因组变异图谱资源库[J]. 遗传, 2018, 40(11): 1048-1054.
[4]	陈德富,卢大儒,张飞雄,张根发. 中国遗传学教学40年发展及展望[J]. 遗传, 2018, 40(10): 916-923.
[5]	潘园园, 刘钢. 中国丝状真菌次级代谢分子调控研究进展[J]. 遗传, 2018, 40(10): 874-887.
[6]	杨湛澄, 黄河天, 闫青霞, 王雅春, 俞英, 陈绍祜, 孙东晓, 张胜利, 张毅. 利用高密度SNP标记分析中国荷斯坦牛基因组近交[J]. 遗传, 2017, 39(1): 16-23.
[7]	谢建平, 韩玉波, 刘钢, 白林泉. 2015年中国微生物遗传学研究领域若干重要进展[J]. 遗传, 2016, 38(9): 765-790.
[8]	李元丰, 韩玉波, 曹鹏博, 孟金凤, 李海北, 秦庚, 张锋, 靳光付, 杨勇, 邬玲仟, 平杰, 周钢桥. 2015年中国医学遗传学研究领域若干重要进展[J]. 遗传, 2016, 38(5): 363-390.
[9]	陈凡国,李晴晴. 灯刷染色体的研究进展及其在遗传学教学中的思考[J]. 遗传, 2016, 38(2): 170-177.
[10]	郭奕斌. 基因诊断中测序技术的应用及优缺点[J]. 遗传, 2014, 36(11): 1121-1130.
[11]	张计育，王庆菊，郭忠仁. 植物AP2/ERF类转录因子研究进展[J]. 遗传, 2012, 34(7): 835-847.
[12]	宋健，郭勇，于丽杰，邱丽娟. 大豆种皮色相关基因研究进展[J]. 遗传, 2012, 34(6): 687-694.
[13]	陈凡国，侯丙凯. 巴氏小体案例在遗传学教学中的应用[J]. 遗传, 2012, 34(4): 503-508.
[14]	陈涛，王小蓉，罗华，王春涛，张家志，罗明敏. 9个野生中国樱桃群体叶绿体DNA trnQ-rps16序列变异及其遗传结构分析[J]. 遗传, 2012, 34(11): 1475-1483.
[15]	尼桂琰，张哲，姜力，马裴裴，张勤，丁向东. 利用全基因组连锁不平衡估计中国荷斯坦牛有效群体大小[J]. 遗传, 2012, 34(1): 50-58.