[1] Chen YC, Cui YQ, Shen B, Niu YY, Zhao XY, Wang L, Wang JY, Li W, Zhou Q, Ji WZ, Sha JH, Huang XX. Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys. Cell Res , 2015, 25(2): 262-265. [2] Wan HF, Feng CJ, Teng F, Yang SH, Hu BY, Niu YY, Xiang AP, Fang WZ, Ji WZ, Li W, Zhao XY, Zhou Q. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res , 2015, 25(2): 258-261. [3] Kang Y, Zheng B, Shen B, Chen YC, Wang L, Wang JY, Niu YY, Cui YQ, Zhou JK, Wang H, Guo XJ, Hu B, Zhou Q, Sha JH, Ji WZ, Huang XX. CRISPR/Cas9- mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Hum Mol Genet , 2015, 24(25): 7255- 7264. [4] Chen YC, Zheng YH, Kang Y, Yang WL, Niu YY, Guo XY, Tu ZC, Si CY, Wang H, Xing RX, Pu XQ, Yang SH, Li SH, Ji WZ, Li XJ. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Hum Mol Genet , 2015, 24(13): 3764-3774. [5] Chen YC, Niu YY, Li YJ, Ai ZY, Kang Y, Shi H, Xiang Z, Yang ZH, Tan T, Si W, Li W, Xia XS, Zhou Q, Ji WZ, Li TQ. Generation of Cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell Stem Cell , 2015, 17(1): 116-124. [6] Wu HB, Wang YS, Zhang Y, Yang MQ, Lv JX, Liu J, Zhang Y. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci USA , 2015, 112(13): E1530-E1539. [7] Zou QJ, Wang XM, Liu YZ, Ouyang Z, Long HB, Wei S, Xin JG, Zhao BT, Lai SS, Shen J, Ni QC, Yang HQ, Zhong HL, Li L, Hu MH, Zhang QJ, Zhou ZD, He JX, Yan QM, Fan NN, Zhao Y, Liu ZM, Guo L, Huang J, Zhang GG, Ying J, Lai LX, Gao X. Generation of gene-target dogs using CRISPR/Cas9 system. J Mol Cell Biol , 2015, 7(6): 580-583. [8] Kou ZH, Wu Q, Kou XC, Yin CH, Wang H, Zuo ZT, Zhuo Y, Chen A, Gao SR, Wang XQ. CRISPR/Cas9- mediated genome engineering of the ferret. Cell Res , 2015, 25(12): 1372-1375. [9] Zhong CQ, Yin Q, Xie ZF, Bai MZ, Dong R, Tang W, Xing YH, Zhang HL, Yang SM, Chen LL, Bartolomei MS, Ferguson-Smith A, Li DS, Yang L, Wu YX, Li JS. CRISPR-Cas9-mediated genetic screening in mice with haploid embryonic stem cells carrying a guide RNA library. Cell Stem Cell , 2015, 17(2): 221-232. [10] Wu YX, Zhou H, Fan XY, Zhang Y, Zhang M, Wang YH, Xie ZF, Bai MZ, Yin Q, Liang D, Tang W, Liao JY, Zhou CK, Liu WJ, Zhu P, Guo HS, Pan H, Wu CL, Shi HJ, Wu LG, Tang FC, Li JS. Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells. Cell Res , 2015, 25(1): 67-79. [11] Yuan Y, Zhou Q, Wan HF, Shen B, Wang XP, Wang M, Feng CJ, Xie MM, Gu TT, Zhou T, Fu R, Huang XX, Zhou Q, Sha JH, Zhao XY. Generation of fertile offspring from Kit w / Kit wv mice through differentiation of gene corrected nuclear transfer embryonic stem cells. Cell Res , 2015, 25(7): 851-863. [12] Li JH, Shou J, Guo Y, Tang YX, Wu YH, Jia ZL, Zhai Y, Chen ZF, Xu Q, Wu Q. Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol , 2015, 7(4): 284-298. [13] Li J, Zhang BB, Ren YG, Gu SY, Xiang YH, Du JL. Intron targeting-mediated and endogenous gene integrity-maintaining knockin in zebrafish using the CRISPR/ Cas9 system. Cell Res , 2015, 25(5): 634-637. [14] Qin W, Liang F, Feng Y, Bai HP, Yan RB, Li S, Lin S. Expansion of CRISPR/Cas9 genome targeting sites in zebrafish by Csy4-based RNA processing. Cell Res , 2015, 25(9): 1074-1077. [15] Long LJ, Guo H, Yao D, Xiong K, Li YJ, Liu PP, Zhu ZY, Liu D. Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C . elegans and D . rerio . Cell Res , 2015, 25(5): 638-641. [16] Du YN, Meng QZ, Zhang J, Sun M, Shen B, Jiang H, Kang NN, Gao JM, Huang XX, Liu JH. Functional annotation of cis -regulatory elements in human cells by dCas9/sgRNA. Cell Res , 2015, 25(7): 877-880. [17] Liang PP, Xu YW, Zhang XY, Ding CH, Huang R, Zhang Z, Lv J, Xie XW, Chen YX, Li YJ, Sun Y, Bai Y |