真核生物mRNA翻译起始机制研究进展

doi:10.16288/j.yczz.17-393

遗传 ›› 2018, Vol. 40 ›› Issue (8): 607-619.doi: 10.16288/j.yczz.17-393

• 综述 • 下一篇

真核生物mRNA翻译起始机制研究进展

郑超星¹,马小凤¹,张永华¹,李洪杰²,张根发¹()

^1. 北京师范大学生命科学学院,北京 100875
^2. 中国农业科学院作物科学研究所,北京 100081

收稿日期:2018-04-09 修回日期:2018-06-25 出版日期:2018-08-16 发布日期:2018-07-12
通讯作者: 张根发 E-mail:gfzh@bnu.edu.cn
作者简介:郑超星,硕士研究生,专业方向:植物分子遗传学。E-mail: superstarz@163.com
基金资助:
国家自然科学基金项目资助(31470399)

Research progress in the mechanism of translation initiation of eukaryotic mRNAs

Zheng Chaoxing¹,Ma Xiaofeng¹,Zhang Yonghua¹,Hongjie Li²,Genfa Zhang¹()

^1. College of Life Sciences, Beijing Normal University, Beijing 100875, China
^2. Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Received:2018-04-09 Revised:2018-06-25 Online:2018-08-16 Published:2018-07-12
Contact: Zhang Genfa E-mail:gfzh@bnu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(31470399)

摘要/Abstract

摘要：

在真核生物中,mRNA翻译是一个复杂的多步骤过程,包括起始、延伸和终止3个阶段。其中,起始阶段的调控是影响mRNA翻译的关键。目前已经发现,mRNA翻译起始方式有多种,以最早发现的m ⁷G帽依赖性扫描机制最为经典,但当细胞处于逆境,经典起始机制受到抑制时,其他类型的起始机制会将其替代以保证翻译的顺利进行。本文对目前已发现的真核生物mRNA不同翻译起始机制特别是经典起始机制的替代机制进行了综述,旨在为深入认识真核生物基因在翻译水平上的表达调控提供参考。

关键词: 翻译起始, 真核生物mRNA, 帽依赖性扫描, IRES, CITE

Abstract:

The translation of mRNA is a complicated multi-step process, including initiation, elongation and termination. Among them, the regulation of the initial stage plays the key role. There are many ways to initiate mRNA translation, and the most classical way is the m ⁷G cap-dependent scanning mechanism that was also the first mechanism identified. When cells encounter adversity and the classical mechanism is inhibited, other types of translation initiation mechanisms will be activated. In this review, we summarize the translation initiation mechanisms of eukaryotic mRNAs, especially some alternative mechanisms. It will provide a reference for further understanding of the expression and regulation of eukaryotic genes at the translation levels.

Key words: translate initiation, eukaryotic mRNA, m ⁷G cap-dependent scanning, IRES, CITE

郑超星, 马小凤, 张永华, 李洪杰, 张根发. 真核生物mRNA翻译起始机制研究进展[J]. 遗传, 2018, 40(8): 607-619.

Chao-xing Zheng, Xiao-feng Ma, Yong-hua Zhang, Hongjie Li, Genfa Zhang. Research progress in the mechanism of translation initiation of eukaryotic mRNAs[J]. Hereditas(Beijing), 2018, 40(8): 607-619.

参考文献

[1]	Haimov O, Sinvani H, Dikstein R . Cap-dependent, scanning-free translation initiation mechanisms. Biochim Biophys Acta, 2015,1849(11):1313-1318.
[2]	Lacerda R, Menezes J, Rom?o L . More than just scanning: the importance of cap-independent mRNA translation initiation for cellular stress response and cancer. Cell Mol Life Sci, 2017,74(9):1659-1680.
[3]	Kozak M . The scanning model for translation: an update. J Cell Biol, 1989,108(2):229-241.
[4]	Andreev DE, Dmitriev SE, Loughran G, Terenin IM, Baranov PV, Shatsky IN . Translation control of mRNAs encoding mammalian translation initiation factors. Gene, 2018,651:174-182.
[5]	Hershey JW . Regulation of protein synthesis and the role of eIF3 in cancer. Braz J Med Biol Res, 2010,43(10):920-930.
[6]	Kashiwagi K, Takahashi M, Nishimoto M, Hiyama TB, Higo T, Umehara T, Sakamoto K, Ito T, Yokoyama S . Crystal structure of eukaryotic translation initiation factor 2B. Nature, 2016,531(7592):122-125.
[7]	Wek RC, Jiang HY, Anthony TG . Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans, 2006,34(Pt 1):7-11.
[8]	Kamenska A, Simpson C , Standart N. eIF4E-binding proteins: new factors, new locations, new roles. Biochem Soc T, 2014,42(4):1238-1245.
[9]	Jackson RJ, Hellen CU, Pestova TV . The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Bio, 2010,11(2):113-127.
[10]	Jang SK, Paek KY . Cap-dependent translation is mediated by 'RNA looping' rather than 'ribosome scanning'. RNA Biol, 2015,13(1):1-5.
[11]	Miras M, Miller WA, Truniger V, Aranda MA . Non-canonical translation in plant RNA viruses. Front Plant Sci, 2017,8:494.
[12]	Moshonov S, Elfakess R, Golan-Mashiach M, Sinvani H, Dikstein R . Links between core promoter and basic gene features influence gene expression. BMC Genomics, 2008,9(1):92-102.
[13]	Pesole G, Mignone F, Gissi C, Licciulli F, Liuni S . Structural and functional features of eukaryotic mRNA untranslated regions. Gene, 2001,276(1):73-81.
[14]	Kozak M . A short leader sequence impairs the fidelity of initiation by eukaryotic ribosomes. Gene Expr, 1991,1(2):111-115.
[15]	Kozak M . Effects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro. Gene Expr, 1991,1(2):117-125.
[16]	Pisarev AV, Kolupaeva VG, Yusupov MM, Hellen CU, Pestova TV . Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes. EMBO J

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真核生物mRNA翻译起始机制研究进展

Research progress in the mechanism of translation initiation of eukaryotic mRNAs

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