遗传 ›› 2020, Vol. 42 ›› Issue (6): 548-555.doi: 10.16288/j.yczz.20-037

• 综述 • 上一篇    下一篇

泛素化途径在奶牛乳脂生成过程中的调控作用

刘莉莉1, 郭爱伟1, 李青青1,2, 吴培福1, 杨亚晋1, 陈粉粉1, 李素华1, 郭盘江1, 张勤3   

  1. 1. 西南林业大学生命科学学院,昆明 650224
    2. 云南昆明翔昊科技有限公司,昆明 650204
    3. 山东农业大学动物科技学院,泰安 271018
  • 收稿日期:2020-02-10 修回日期:2020-04-15 出版日期:2020-06-20 发布日期:2020-05-07
  • 作者简介:刘莉莉,博士,讲师,研究方向:动物遗传育种。E-mail:liulily0518@163.com
  • 基金资助:
    国家自然科学基金项目资助编号(31902152);国家自然科学基金项目资助编号(31872327)

The regulation of ubiquitination in milk fat synthesis in bovine

Liu Lili1, Guo Aiwei1, Li Qingqing1,2, Wu Peifu1, Yang Yajin1, Chen Fenfen1, Li Suhua1, Guo Panjiang1, Zhang Qin3   

  1. 1. College of Life Science, Southwest Forestry University, Kunming 650224, China
    2. Kunming Xianghao Technology Co. Ltd., Kunming 650204, China
    3. College of Animal Science and Technology, Shandong Agricultural University, Tai’an 271000, China
  • Received:2020-02-10 Revised:2020-04-15 Online:2020-06-20 Published:2020-05-07
  • Supported by:
    Supported by the National Natural Science Foundation of China Nos(31902152);Supported by the National Natural Science Foundation of China Nos(31872327)

摘要:

泛素化途径是真核细胞中主要的蛋白质降解途径,其中泛素-蛋白酶体途径主要降解细胞质中的蛋白,溶酶体途径主要降解细胞膜蛋白。研究表明,泛素化途径在奶牛乳腺上皮细胞脂肪酸合成过程中起着关键的调控作用。在脂肪酸摄取过程中,泛素化途径调控异常可导致细胞膜上脂肪酸转运蛋白的泛素化降解受阻,使脂肪酸转运增强,进而增加奶牛乳脂的生成。本文综述了泛素化途径在奶牛乳脂生成过程中对相关蛋白的调控作用,以期为奶牛乳脂性状后续相关研究提供参考和新的思路。

关键词: 泛素化途径, 泛素-蛋白酶体系统, 溶酶体系统, 乳脂生成, 脂肪酸

Abstract:

Ubiquitination signaling is the main pathway of protein degradation in eukaryotic cells. Ubiquitin-proteasome system degrades the ubiquitinated cytoplasmic proteins and lysosome pathway mainly degrades the ubiquitinated membrane proteins. Previous studies have shown that ubiquitination signaling plays a critical role in fatty acids synthesis. In the process of fatty acids import, disruption of ubiquitination could prevent the degradation of fatty acid transport proteins, thereby promoting fatty acids import and milk fat synthesis in bovine primary mammary epithelial cells. In this review, we summarize the signal transduction and regulation mechanism of ubiquitination signaling in milk fat synthesis, which may provide references and new ideas for future research on milk fat traits in dairy cows.

Key words: ubiquitination, ubiquitinated-proteasome system, lysosome pathway, milk fat synthesis, fatty acid