G蛋白偶联受体40研究进展

doi:10.3724/SP.J.1005.2013.00027

遗传 ›› 2013, Vol. 35 ›› Issue (1): 27-34.doi: 10.3724/SP.J.1005.2013.00027

G蛋白偶联受体40研究进展

武珅, 陆涛峰, 武爽, 关伟军

中国农业科学院北京畜牧兽医研究所, 北京100193

收稿日期:2012-06-30 修回日期:2012-08-15 出版日期:2013-01-20 发布日期:2013-01-25
通讯作者: 关伟军 E-mail:Weijunguan301@gmail.com
基金资助:
转基因生物新品种培育科技重大专项(编号：2011ZX08009-003-006)资助

Research progress in G protein-coupled receptor 40

WU Shen, LU Tao-Feng, WU Shuang, GUAN Wei-Jun

Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Received:2012-06-30 Revised:2012-08-15 Online:2013-01-20 Published:2013-01-25

摘要/Abstract

摘要： G蛋白偶联受体40(G protein-coupled receptor 40, GPR40)是一种具有7个跨膜α螺旋结构的G蛋白偶联受体, 主要分布于胰腺细胞和神经系统细胞。它能与机体内游离的中长链脂肪酸结合, 激活细胞内信号通路, 从而调节其生理功能。在胰岛细胞中, GPR40可被游离脂肪酸激活, 促使细胞内钙离子浓度升高, 进而促进胰岛素释放。根据这一机理, 以GPR40为靶点的激动剂类药物相继被开发, 用于糖尿病治疗。GPR40也参与神经发生过程, 但到目前为止其相关机制尚不清楚。文章从基因结构、表达调控、蛋白配体及应用、生理功能等方面详细介绍了GPR40的研究现状, 总结了目前研究中所遇到的问题, 并对未来的研究热点进行展望。

关键词: GPR40, 中长链脂肪酸, 胰岛素分泌, 神经发生, 味觉

Abstract: GPR40 is one of the G protein-coupled receptors, which has 7 transmembrance spanning helical bundles. GPR40 distributes in pancreas and central nervous system. It can be bound by medium and long chain fatty acid and activate the intracellular signal pathways, which in turn regulates the function of cells. In b-cell, intracellular calcium concentration elevates when GPR40 is binding to fatty acid, thereby promoting the release of insulin. According to the theory, new drugs, the agonist of GPR40, have been used for prepreventing and treating the diabetas. In the nervous system, GPR40 is involved in neurogenesis, but the mechanism how GPR40 works is unclear until now. In thisreview, the research progressof GPR40 was reviewed, especially about the structure and characteristics of GPR40 gene, ligands and function. We focused on the problems encountered in the current research and the hot points in the future.

Key words: GPR40, medium and long chain fatty acid, insulin secret, neurogenesis, gustation

武珅，陆涛峰，武爽，关伟军. G蛋白偶联受体40研究进展[J]. 遗传, 2013, 35(1): 27-34.

WU Shen LU Tao-Feng WU Shuang GUAN Wei-Jun. Research progress in G protein-coupled receptor 40[J]. HEREDITAS, 2013, 35(1): 27-34.

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G蛋白偶联受体40研究进展

Research progress in G protein-coupled receptor 40

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