遗传 ›› 2021, Vol. 43 ›› Issue (7): 654-664.doi: 10.16288/j.yczz.20-230

• 综述 • 上一篇    下一篇

lncRNA调控畜禽抗病力性状研究进展

杨金艳1,2(), 刘雪琴1,2(), 文天琦1, 孙愉洪1, 俞英1()   

  1. 1. 中国农业大学动物科学技术学院,北京 100193
    2. 云南农业大学动物科学技术学院,昆明 650201
  • 收稿日期:2021-01-10 修回日期:2021-06-16 出版日期:2021-07-20 发布日期:2021-06-28
  • 通讯作者: 俞英 E-mail:cauyangjinyan@163.com;cauliuxueqin@163.com;yuying@cau.edu.cn
  • 作者简介:杨金艳,本科生,专业方向:动物科学。E-mail: cauyangjinyan@163.com|刘雪琴,在读博士研究生,研究方向:动物分子数量遗传学。E-mail: cauliuxueqin@163.com
  • 基金资助:
    国家自然科学基金项目编号(31961143009);国家自然科学基金项目编号(31272420);北京市自然科学基金项目编号(6182021);北京市奶牛产业创新团队项目编号(BAIC06);国家奶牛产业技术体系项目资助编号(CARS-36)

Progress on lncRNA regulated disease resistance traits in domesticated animals

Yang Jinyan1,2(), Liu Xueqin1,2(), Wen Tianqi1, Sun Yuhong1, Yu Ying1()   

  1. 1. College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
    2. College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China
  • Received:2021-01-10 Revised:2021-06-16 Online:2021-07-20 Published:2021-06-28
  • Contact: Yu Ying E-mail:cauyangjinyan@163.com;cauliuxueqin@163.com;yuying@cau.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China Nos(31961143009);Supported by the National Natural Science Foundation of China Nos(31272420);the Beijing Natural Science Foundation No(6182021);the Beijing Dairy Industry Innovation Team No(BAIC06);the National Dairy Industry Technology System Project No(CARS-36)

摘要:

长链非编码RNA (long non-coding RNA, lncRNA)是一类长度大于200个核苷酸的非编码RNA分子。lncRNA虽然不具备蛋白编码能力,但可通过转录调控、转录后调控及表观遗传修饰调控等方式影响基因的表达,进而影响性状的表型。在现代畜牧业生产中,除提高生长发育和产量性状外,研究免疫因子、细胞因子等抗病力相关指标及性状的调控机制,对提高和改善畜禽的健康、福利及公共卫生尤为重要。近年来,利用lncRNA研究鸡(Gallus gallus)、猪(Sus scrofa)、牛(Bos taurus)等重要畜禽的抗病力性状的调控机制取得了一定进展,为将表观遗传标记应用于动物抗病遗传育种打下了一定的基础。本文介绍了lncRNA的生物学功能和产生机制,着重阐述了lncRNA对畜禽抗病力性状的调控作用及研究进展,以期为lncRNA在畜禽抗病遗传育种方面的研究及应用提供科学依据。

关键词: lncRNA, 畜禽, 抗病力性状

Abstract:

Long non-coding RNA (lncRNA) is a class of non-coding RNAs with a length greater than 200 nucleotides. Although lncRNAs do not have any protein coding capability, they can affect the phenotypes of traits by influencing gene expression through transcriptional regulation, post-transcriptional regulation, and epigenetic modification. In modern animal husbandry production, besides increasing growth and yield traits, investigations on the regulation mechanisms of immune factors, cytokines and other disease resistance-related indicators and traits are particularly important for improving the health and welfare of domesticated animals as well as public health. In recent years, researchers have made significant progress in understanding the regulatory mechanisms of lncRNA on the disease resistance traits of chickens (Gallus gallus), pigs (Sus scrofa), cattle (Bos taurus) and other important domesticated animals, thereby laying the basic foundation for the translational application of epigenetic markers in breeding of animals with disease resistance. In this review, we briefly introduce the biological functions and the origins of lncRNAs, then focus on the research progress on the regulatory effects of lncRNAs on disease resistance traits of domesticated animals, and thus providing the scientific basis for the research of lncRNA and its application in the breeding of disease-resistant animals.

Key words: lncRNA, domesticated animals, disease-resistance traits