lncRNA调控畜禽抗病力性状研究进展

doi:10.16288/j.yczz.20-230

遗传 ›› 2021, Vol. 43 ›› Issue (7): 654-664.doi: 10.16288/j.yczz.20-230

lncRNA调控畜禽抗病力性状研究进展

杨金艳^1,²(), 刘雪琴^1,²(), 文天琦¹, 孙愉洪¹, 俞英¹()

1. 中国农业大学动物科学技术学院,北京 100193
2. 云南农业大学动物科学技术学院,昆明 650201

收稿日期:2021-01-10 修回日期:2021-06-16 出版日期:2021-07-20 发布日期:2021-06-28
通讯作者: 俞英 E-mail:cauyangjinyan@163.com;cauliuxueqin@163.com;yuying@cau.edu.cn
作者简介:杨金艳,本科生,专业方向：动物科学。E-mail: cauyangjinyan@163.com|刘雪琴,在读博士研究生,研究方向：动物分子数量遗传学。E-mail: cauliuxueqin@163.com
基金资助:
国家自然科学基金项目编号(31961143009);国家自然科学基金项目编号(31272420);北京市自然科学基金项目编号(6182021);北京市奶牛产业创新团队项目编号(BAIC06);国家奶牛产业技术体系项目资助编号(CARS-36)

Progress on lncRNA regulated disease resistance traits in domesticated animals

Jinyan Yang^1,²(), Xueqin Liu^1,²(), Tianqi Wen¹, Yuhong Sun¹, Ying Yu¹()

1. College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
2. College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China

Received:2021-01-10 Revised:2021-06-16 Online:2021-07-20 Published:2021-06-28
Contact: Yu Ying E-mail:cauyangjinyan@163.com;cauliuxueqin@163.com;yuying@cau.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China Nos(31961143009);Supported by the National Natural Science Foundation of China Nos(31272420);the Beijing Natural Science Foundation No(6182021);the Beijing Dairy Industry Innovation Team No(BAIC06);the National Dairy Industry Technology System Project No(CARS-36)

摘要/Abstract

摘要：

长链非编码RNA (long non-coding RNA, lncRNA)是一类长度大于200个核苷酸的非编码RNA分子。lncRNA虽然不具备蛋白编码能力,但可通过转录调控、转录后调控及表观遗传修饰调控等方式影响基因的表达,进而影响性状的表型。在现代畜牧业生产中,除提高生长发育和产量性状外,研究免疫因子、细胞因子等抗病力相关指标及性状的调控机制,对提高和改善畜禽的健康、福利及公共卫生尤为重要。近年来,利用lncRNA研究鸡(Gallus gallus)、猪(Sus scrofa)、牛(Bos taurus)等重要畜禽的抗病力性状的调控机制取得了一定进展,为将表观遗传标记应用于动物抗病遗传育种打下了一定的基础。本文介绍了lncRNA的生物学功能和产生机制,着重阐述了lncRNA对畜禽抗病力性状的调控作用及研究进展,以期为lncRNA在畜禽抗病遗传育种方面的研究及应用提供科学依据。

关键词: lncRNA, 畜禽, 抗病力性状

Abstract:

Long non-coding RNA (lncRNA) is a class of non-coding RNAs with a length greater than 200 nucleotides. Although lncRNAs do not have any protein coding capability, they can affect the phenotypes of traits by influencing gene expression through transcriptional regulation, post-transcriptional regulation, and epigenetic modification. In modern animal husbandry production, besides increasing growth and yield traits, investigations on the regulation mechanisms of immune factors, cytokines and other disease resistance-related indicators and traits are particularly important for improving the health and welfare of domesticated animals as well as public health. In recent years, researchers have made significant progress in understanding the regulatory mechanisms of lncRNA on the disease resistance traits of chickens (Gallus gallus), pigs (Sus scrofa), cattle (Bos taurus) and other important domesticated animals, thereby laying the basic foundation for the translational application of epigenetic markers in breeding of animals with disease resistance. In this review, we briefly introduce the biological functions and the origins of lncRNAs, then focus on the research progress on the regulatory effects of lncRNAs on disease resistance traits of domesticated animals, and thus providing the scientific basis for the research of lncRNA and its application in the breeding of disease-resistant animals.

Key words: lncRNA, domesticated animals, disease-resistance traits

杨金艳, 刘雪琴, 文天琦, 孙愉洪, 俞英. lncRNA调控畜禽抗病力性状研究进展[J]. 遗传, 2021, 43(7): 654-664.

Jinyan Yang, Xueqin Liu, Tianqi Wen, Yuhong Sun, Ying Yu. Progress on lncRNA regulated disease resistance traits in domesticated animals[J]. Hereditas(Beijing), 2021, 43(7): 654-664.

图/表 3

图1

表1

lncRNA	畜禽	差异表达组织	相关疾病	靶基因	调控方式	参考文献
XLOC_672329/ ALDBGALG0000001429	鸡	鸡原发性巨噬细胞	禽白血病	CH25H/ CISH/IL-1β	cis	[24]
TCONS_00292296/TCONS_ 00212539/TCONS_00079494	鸡	鸡脾脏组织	禽白血病	BBX/BCL11B/ ULK3	cis	[25]
lncRNA ERL	鸡	GaHV-2基因组 TR_L/IR_L区域	禽马立克病	ADAR1	/	[26]
linc-GALMD1	鸡	CD4+ T细胞和鸡淋巴瘤细胞	禽马立克病	EPYC	trans	[27]
linc-stab1	鸡	鸡法式囊	禽马立克病	SATB1	cis	[28]
MSTRG.360.1/MSTRG.6754.1/ MSTRG.15539.1	鸡	鸡脾脏组织	禽马立克病	CTLA4/CXCL12	cis	[29]
LNC_001066/LNC_000231	猪	猪回肠组织	C型产气荚膜梭菌型腹泻	TLR8/IRAK3/ TNFRSF11A	trans	[30]
ALDBSSCG0000006854/ XLOC_078370	猪	猪回肠上皮细胞	C型产气荚膜梭菌型腹泻	ABCB1	cis/trans	[31]
ALDBSSCT0000006510/ ALDBSSCT0000004760	猪	猪回肠上皮细胞	C型产气荚膜梭菌型腹泻	TRAF2/MAPK8	trans	[32]
LOC102157546/XLOC_025930	猪	仔猪小肠上皮细胞	仔猪腹泻	KCNMB1/GRB2	trans	[33]
TCONS_00058367	猪	猪小肠上皮细胞	猪传染性胃肠炎	PML	cis	[34]
lncRNA 9606	猪	猪小肠上皮细胞	猪流行性腹泻	TCR	cis	[35]
lncRNA XR_297549.1	猪	猪肺泡巨噬细胞	猪繁殖与呼吸综合征	PTGS2	cis/trans	[36]
TCONS_00054158	猪	猪子宫内膜上皮细胞	猪繁殖与呼吸综合征	TNFSF10	cis	[37]
LTCONS_00010766/ LTCONS_00045988	猪	猪子宫内膜上皮细胞	猪繁殖与呼吸综合征	MUM1X7/GAMT	cis	[38]
lncRNA H19	牛	牛乳腺上皮细胞	奶牛乳房炎	CCL5/CXCL2	/	[39]
lncRNA XIST	牛	牛乳腺上皮细胞	奶牛乳房炎	NF-κB p65	cis	[40]
ALDBBTAT0000007617/ ALDBBTAT0000006520	牛	牛乳腺组织	奶牛乳房炎	TLR2/MyD88	trans	[41]
ALDBBTAG0000003135/ XLOC_018926	牛	牛肾细胞	牛病毒性腹泻	CHD2/ZMAT3	cis	[42]
LOC112443855/LOC112448807/ LOC100847453	牛	牛肾细胞	牛病毒性腹泻	ATG4D/ATG16L1	cis	[43]
XLOC_033995	牛	牛巨噬细胞	牛副结核病	TNFAIP3	trans	[44]
MSTRG.12.1	牛	牛瘤胃组织	亚急性瘤胃酸中毒	/	trans	[45]
XLOC_000016/XLOC_002851	牛	角粘膜层组织	牛角鳞状细胞癌	CNFN/CDSN	cis	[46]
TOCNS_00059692/ TCONS_00053949	羊	绵羊脾脏	腹泻	TIMM29/CARM1/ MYO1G	cis	[47]
IFNG-AS1	人、猪、牛、羊	布氏杆菌病患者血清	布氏杆菌病	IFNG	/	[48]
PSMB8-AS1	人、鸡、猪	人肺上皮细胞	H1N1	PSMB8/TAP1	cis	[49]

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作用机制	lncRNA	主要靶标	物种	参考文献
基因组印记	H19	PRC2复合物;let-7	人	[13,14]
基因组印记	XIST	PRC2复合物	人	[15,16]
染色质重塑	HOTAIR	PRC2复合物	小鼠	[17]
	Kcnq1ot1	PRC2复合物	小鼠	[18]
	Air	G9a转移酶	小鼠	[19]
调控细胞凋亡周期	Gas5	糖皮质激素受体的DNA结合域	小鼠	[20]
控制mRNA降解	1/2-SBSRNA 1	STUA1;STUA2	小鼠	[21]
剪接调控	MALAT1	丝氨酸/精氨酸(SR)剪切因子	人	[22]
翻译调控	Uchl1-as1	UCHL1蛋白	小鼠	[23]

lncRNA调控畜禽抗病力性状研究进展

Progress on lncRNA regulated disease resistance traits in domesticated animals

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