长链非编码RNA在血液系统肿瘤中作用的研究进展

doi:10.16288/j.yczz.15-261

遗传 ›› 2015, Vol. 37 ›› Issue (11): 1095-1104.doi: 10.16288/j.yczz.15-261

长链非编码RNA在血液系统肿瘤中作用的研究进展

胡婉莉¹,高艾²

1. 首都医科大学基础医学院2012级7年制临床医学3班, 北京 100069;
2. 首都医科大学公共卫生学院, 北京 100069

收稿日期:2015-06-04 修回日期:2015-09-07 出版日期:2015-11-20 发布日期:2015-09-10
通讯作者: 高艾, 博士,副教授,硕士研究生导师;研究方向：环境因素致造血系统损伤的表观遗传机制。E-mail: gaoai0980@163.com E-mail:736508060@qq.com
作者简介:胡婉莉,本科在读。E-mail:736508060@qq.com
基金资助:
国家自然科学基金项目(编号：81472957、81172639),北京市自然科学基金项目(编号：7142020)和北京市青年拔尖人才项目(编号：CIT&TCD201404187)资助

The role of long non-coding RNAs in hematologic malignancies

Wanli Hu¹,Ai Gao²

1. School of Basic Medical Sciences, Long Duration Clinical Expertise 2012 Grade 3 Class, Capital Medical University, Beijing 100069, China;
2. School of Public Health, Capital Medical University, Beijing 100069, China

Received:2015-06-04 Revised:2015-09-07 Online:2015-11-20 Published:2015-09-10

摘要/Abstract

摘要： 随着分子生物学技术的飞速发展,人们对于长链非编码RNA(Long non-coding RNA,lncRNA)的研究越来越深入。lncRNA不仅在生物体正常生物活动中不可或缺,还在许多疾病尤其是肿瘤中扮演重要角色。已有的研究表明多种lncRNA与血液系统肿瘤密切相关,具有影响抑癌基因p15表达、p53蛋白功能,以及与miRNA相互作用参与疾病等功能。本文综述了血液系统肿瘤相关的lncRNA并着重介绍与p15、p53、miRNA有关的lncRNA以及它们的相互作用在疾病中发挥的功能,以期能够全面了解血液系统肿瘤相关lncRNA的作用特点,为血液系统肿瘤的研究、诊断以及治疗提供新的思路。

关键词: lncRNA, 白血病, p15, p53, miRNA

Abstract: With the rapid development of molecular biology technology, researchers have got much deeper understanding of the role of long non-coding RNA (lncRNA). It is not only indispensable for biological processes, but also plays an important role in human diseases especially in tumor. Previous studies have shown that a variety of lncRNAs are closely associated with hematologic malignancies. These lncRNAs are involved in diseases through diverse functions including affecting the expression of tumor suppressor gene p15, regulating p53 protein function, and interacting with miRNAs. In this review, we summarize the hematological tumor-associated lncRNAs and focus on p15, p53 and miRNA-related lncRNAs as well as the role of their interaction in hematological malignancies, which may provide a comprehensive understanding of the role of hematological tumor-associated lncRNAs and some insights for research, diagnosis and treatment of hematologic malignancies.

Key words: lncRNA, leukemia, p15, p53, miRNA

胡婉莉,高艾. 长链非编码RNA在血液系统肿瘤中作用的研究进展[J]. 遗传, 2015, 37(11): 1095-1104.

Wanli Hu,Ai Gao. The role of long non-coding RNAs in hematologic malignancies[J]. HEREDITAS(Beijing), 2015, 37(11): 1095-1104.

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长链非编码RNA在血液系统肿瘤中作用的研究进展

The role of long non-coding RNAs in hematologic malignancies

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