遗传 ›› 2015, Vol. 37 ›› Issue (11): 1095-1104.doi: 10.16288/j.yczz.15-261
胡婉莉1,高艾2
收稿日期:
2015-06-04
修回日期:
2015-09-07
出版日期:
2015-11-20
发布日期:
2015-09-10
通讯作者:
高艾, 博士,副教授,硕士研究生导师;研究方向:环境因素致造血系统损伤的表观遗传机制。E-mail: gaoai0980@163.com
E-mail:736508060@qq.com
作者简介:
胡婉莉,本科在读。E-mail:736508060@qq.com
基金资助:
Wanli Hu1,Ai Gao2
Received:
2015-06-04
Revised:
2015-09-07
Online:
2015-11-20
Published:
2015-09-10
摘要: 随着分子生物学技术的飞速发展,人们对于长链非编码RNA(Long non-coding RNA,lncRNA)的研究越来越深入。lncRNA不仅在生物体正常生物活动中不可或缺,还在许多疾病尤其是肿瘤中扮演重要角色。已有的研究表明多种lncRNA与血液系统肿瘤密切相关,具有影响抑癌基因p15表达、p53蛋白功能,以及与miRNA相互作用参与疾病等功能。本文综述了血液系统肿瘤相关的lncRNA并着重介绍与p15、p53、miRNA有关的lncRNA以及它们的相互作用在疾病中发挥的功能,以期能够全面了解血液系统肿瘤相关lncRNA的作用特点,为血液系统肿瘤的研究、诊断以及治疗提供新的思路。
胡婉莉,高艾. 长链非编码RNA在血液系统肿瘤中作用的研究进展[J]. 遗传, 2015, 37(11): 1095-1104.
Wanli Hu,Ai Gao. The role of long non-coding RNAs in hematologic malignancies[J]. HEREDITAS(Beijing), 2015, 37(11): 1095-1104.
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