病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡

doi:10.16288/j.yczz.23-191

遗传 ›› 2023, Vol. 45 ›› Issue (11): 986-997.doi: 10.16288/j.yczz.23-191

病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡

杨茂艺¹(), 崔潇月^2,³, 郑诗棋², 马诗瑶², 郑增长⁴(), 邓万燕²()

1.重庆医科大学感染性疾病分子生物学教育部重点实验室，重庆 400010
2.重庆医科大学基础医学院病原教研室，重庆 400010
3.遂宁市中心医院基础实验室，遂宁 629000
4.同济大学附属东方医院，上海 200120

收稿日期:2023-07-18 修回日期:2023-10-18 出版日期:2023-11-20 发布日期:2023-11-02
通讯作者: 郑增长,邓万燕 E-mail:yang9910150028@163.com;dengwanyan@cqmu.edu.cn;zhengzengzhang@126.com
作者简介:杨茂艺，硕士研究生，专业方向：临床检验诊断学。E-mail: yang9910150028@163.com。
基金资助:
重庆市自然科学基金创新发展联合基金(CSTB2022NSCQ-LZX0031)

Inhibiting pyroptosis: novel immune evasion strategies for pathogens

Maoyi Yang¹(), Xiaoyue Cui^2,³, Shiqi Zheng², Shiyao Ma², Zengzhang Zheng⁴(), Wanyan Deng²()

1. Key Laboratory of Molecular Biology on Infectious Disease, Ministry of Education, Chongqing Medical University，Chongqing 400010, China
2. Department of Pathogenic Biology, College of Basic Medicine, Chongqing Medical University, Chongqing 400010, China
3. Department of Basic Laboratory, Suining Central Hospital, Suining 629000, China
4. Shanghai East Hospital, Tongji University, Shanghai 200120, China

Received:2023-07-18 Revised:2023-10-18 Published:2023-11-20 Online:2023-11-02
Contact: Zengzhang Zheng,Wanyan Deng E-mail:yang9910150028@163.com;dengwanyan@cqmu.edu.cn;zhengzengzhang@126.com
Supported by:
Sponsored by the Natural Science Foundation of Chongqing, China(CSTB2022NSCQ-LZX0031)

摘要/Abstract

摘要：

细胞焦亡是一种由Gasdermin家族蛋白介导的新型程序性细胞死亡。当宿主细胞感应病原体感染或其他危险信号时，Gasdermin家族蛋白被切割活化并诱导细胞焦亡。细胞焦亡过程往往伴随大量炎性细胞因子释放，这些炎性细胞因子在宿主清除病原体过程中发挥着至关重要作用，而病原体在与宿主长期“博弈”过程中也进化出抑制细胞焦亡的策略以实现免疫逃逸。本文介绍了细胞焦亡的发现历程及其在抗感染免疫中的重要功能，并总结了病原体抑制细胞焦亡的多种新策略及其相关研究进展。深入理解细胞焦亡的发生及调控机制，可揭示相关感染性疾病的发病机制并有助于开发有效的抗感染治疗策略。

关键词: 细胞焦亡, 病原体, 效应蛋白

Abstract:

Pyroptosis is a type of programmed cell death mediated by the Gasdermin family. It is triggered in response to pathogen infection or other danger signals. The activation of Gasdermins leads to pyroptosis and the release of large amounts of inflammatory cytokines. Pyroptosis plays a crucial role in combating pathogen infections, as it helps to eliminate infected cells and activate the immune system. However, pathogens have already developed sophisticated strategies to evade or inhibit pyroptosis, allowing them to persist and facilitate infection. This review provides an overview of the discovery of pyroptosis and its importance in anti-infectious immunity. We also discuss several new strategies for inhibiting pyroptosis by pathogens. A thorough learning of the occurrence and regulation of pyroptosis may reveal the pathogenesis of related infectious diseases and contribute to developing effective anti-infective therapeutic strategies.

Key words: pyroptosis, pathogen, effector protein

杨茂艺, 崔潇月, 郑诗棋, 马诗瑶, 郑增长, 邓万燕. 病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡[J]. 遗传, 2023, 45(11): 986-997.

Maoyi Yang, Xiaoyue Cui, Shiqi Zheng, Shiyao Ma, Zengzhang Zheng, Wanyan Deng. Inhibiting pyroptosis: novel immune evasion strategies for pathogens[J]. Hereditas(Beijing), 2023, 45(11): 986-997.

图/表 2

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逃逸策略	病原体	PAMPs	作用靶点	参考文献
逃逸炎症小体识别	P. aeruginosa	PCN	NLRP3	[41]
	Y. pseudotuberculosis	YopK	NLRP3	[36]
	Y. pestis	YopM	Pyrin	[37,38]
	Sendai Virus	V Protein	NLRP3	[48]
	EVB	BILF1	NLRP3	[44]
	STm	SpvC	NLRP/NLRC4	[50]
	STm	-	NLRC4	[49]
	S. paratyphi A	Long O-antigen chains	NLRP3	[42]
	STm	SsrB	NLRC4	[43]
	STm	SopB	NLRC4	[40]
	KSHV	Orf63	NLRP1	[46]
	A. phagocytophilum	Sialostatin L2	NLRC4	[47]
	S. aureus	AdsA	NLRP3	[39]
	M. tuberculosis	Zmp1	NLRC4	[45]
重编程病原体代谢	E. piscicida	-	NLRP3	[51]
	STm	Aconitase	NLRP3	[52]
	S. aureus	PGN	Caspase-11	[53]
	Y. pestis	-	Caspase-11	[55]
	F. novicidaa	-	Caspase-11	[54,55]
抑制炎性Caspase 的活化	P. aeruginosa	ExoU	Caspase-1	[56]
	Brucella	TcpB	Caspase-1/4/11	[57]
	EPEC/EHEC	NleF	Caspase-4/11	[58,59]
	S. flexneri	OspC3	Caspase-11/4	[60,61]
	S. flexneri	IpaH9.8	GBPs	[62,63]
	C. burnetii	IcaA	Caspase-11	[64]
	EHEC	STX2	Caspase-11	[65]
抑制Gasdermin的活化	SARS-CoV-2	Nucleocapsid	Caspase1	[66]
	Enterovirus 71	3C protease	GSDMD	[67]
	S. flexneri	IpaH7.8	GSDMD/GSDMB	[68~70]
抑制GSDM-NT的成孔功能	M. tuberculosis	PtpB	GSDMD	[74,75]

病原体逃逸宿主固有免疫的新策略：抑制细胞焦亡

Inhibiting pyroptosis: novel immune evasion strategies for pathogens

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