遗传 ›› 2011, Vol. 33 ›› Issue (4): 285-292.doi: 10.3724/SP.J.1005.2011.00285

• 综述 •    下一篇

组蛋白甲基化修饰效应分子的研究进展

宋博研, 朱卫国   

  1. 北京大学医学部生物化学与分子生物学系, 北京 100191
  • 收稿日期:2010-09-25 修回日期:2010-12-20 出版日期:2011-04-20 发布日期:2011-04-25
  • 通讯作者: 朱卫国 E-mail:zhuweiguo@bjmu.edu.cn
  • 基金资助:

    国家自然科学基金项目(编号:90919030, 30921062)资助

Advances in effector protein of histone methylation

SONG Bo-Yan, ZHU Wei-Guo   

  1. Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing 100191, China
  • Received:2010-09-25 Revised:2010-12-20 Online:2011-04-20 Published:2011-04-25
  • Contact: ZHU Wei-Guo E-mail:zhuweiguo@bjmu.edu.cn

摘要: 作为一种重要的表观遗传学调控机制, 组蛋白甲基化修饰在多种生命过程中发挥了重要的作用。细胞内有多种组蛋白甲基化酶和去甲基化酶共同调节组蛋白的修饰状态, 在组蛋白甲基化状态确定后, 多种效应分子特异的读取修饰信息, 从而参与基因转录调控过程。文章从组蛋白甲基化效应分子的作用机制方面综述了这一领域的研究进展。

关键词: 表观遗传学, 组蛋白修饰, 组蛋白甲基化修饰效应蛋白, 基因转录调控

Abstract: As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biological processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effector proteins recognize modification sites specifically, and affect gene transcriptional process. This review mainly focuses on recent advances in histone methylation effector protein’s function mechanism.

Key words: epigenetics, effector protein of methylated histone, histone modification, gene transcription regulation