胰腺早期发育及终末分化细胞重编程为胰岛β细胞的研究进展

doi:10.3724/SP.J.1005.2014.0511

遗传 ›› 2014, Vol. 36 ›› Issue (6): 511-518.doi: 10.3724/SP.J.1005.2014.0511

• 综述 • 下一篇

胰腺早期发育及终末分化细胞重编程为胰岛β细胞的研究进展

曹明君¹, 董焕生², 潘庆杰¹, 王红军¹, 董晓³

1. 青岛农业大学动物科技学院, 青岛 266109;
2. 美国南卡莱罗那医学院, 美国查尔斯顿 29425;
3. 青岛农业大学生命科学学院, 青岛 266109

收稿日期:2013-11-05 修回日期:2014-01-06 出版日期:2014-06-20 发布日期:2014-05-28
通讯作者: 董晓,博士,副教授,研究方向：生殖生理。E-mail:1163553518@qq.com E-mail:caomingjun19881112@163.com
作者简介:曹明君,硕士研究生,专业方向：动物生殖发育与基因工程。E-mail:caomingjun19881112@163.com
基金资助:
青岛农业大学高层次人才科研基金(编号：631114)资助

Progress in early pancreas development and reprogramming of terminally differentiated cells into β cells

Mingjun Cao¹, Huansheng Dong², Qingjie Pan¹, Hongjun Wang¹, Xiao Dong³

1. College of Animal Science, Qingdao Agricultural University, Qingdao 266109, China;
2. Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA;
3. College of Life Science, Qingdao Agricultural University, Qingdao 266109, China

Received:2013-11-05 Revised:2014-01-06 Online:2014-06-20 Published:2014-05-28

摘要/Abstract

摘要：

1型糖尿病是一种由于自体免疫细胞破坏分泌胰岛素的β细胞而引起胰岛素绝对缺乏的自体免疫病。疾病患者需要依靠外源性途径来补给胰岛素, 但胰岛素注射治疗不能根治病症, 也不能有效地预防糖尿病并发症。多能性干细胞以及体细胞重编程产生胰岛素分泌细胞为根治1型糖尿病提供了可能。编程性的细胞能被用来进行移植治疗和药物筛选, 为1型糖尿病的治疗带来了新的希望。当前, 通过相关转录调节因子重编程终末分化细胞为胰岛β细胞已经取得了很大进展。文章对胰腺早期发育、胰腺相关转录调控因子及目前利用终末分化细胞重编程产生胰岛β细胞的研究内容进行了综述。

关键词: 糖尿病, 胰岛β细胞, 胰腺相关转录因子, 重编程

Abstract:

Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the immune system attacks insulin-secreting β cells, thus leading to an absolute deficiency of insulin. Patients must rely on exogenous insulin, which cannot effectively prevent diabetes complications. Generation of insulin-secreting cells by reprogramming of pluripotent stem cells or somatic cells is a potential approach for the treatment of T1DM. These cells can be used for cell therapy and drug screening, and may eventually provide a cure for the disease. Significant progress has been made in generating insulin-secreting cells through the expression of β cell specific transcription factors in stem cells or somatic cells. In this review, we summarize recent research progress in early pancreas development, β cell specific transcription factors and reprogramming of terminally differentiated cells into β cells.

Key words: type 1 diabetes, &beta, cell generation, pancreatic transcription factor, cell reprogramming

曹明君, 董焕生, 潘庆杰, 王红军, 董晓. 胰腺早期发育及终末分化细胞重编程为胰岛β细胞的研究进展[J]. 遗传, 2014, 36(6): 511-518.

Mingjun Cao, Huansheng Dong, Qingjie Pan, Hongjun Wang, Xiao Dong. Progress in early pancreas development and reprogramming of terminally differentiated cells into β cells[J]. HEREDITAS(Beijing), 2014, 36(6): 511-518.

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胰腺早期发育及终末分化细胞重编程为胰岛β细胞的研究进展

Progress in early pancreas development and reprogramming of terminally differentiated cells into β cells

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