遗传 ›› 1991, Vol. 18 ›› Issue (3): 193-199.

• 论文 •    下一篇

中国湖北地区汉族家系补体第四成本(C4)单倍型的检测

汪 策;姚 竹;张文杰;聂晓波;赵修竹   

  1. 同济医科大学病理学教研室,中澳友谊补体实验室,武汉430030
  • 收稿日期:1900-01-01 修回日期:1900-01-01

Investigation of C4 Haplotypes in Han Nationality of Hubei Province in China

Wang Ce, Yao Zhu, Zhang Wenjie, Nie Xiaobo,Zhao Xiuzhu   

  1. Sino-Australia Friendship Laboratory of Complement,Department of Pathophysiology ,Tongji Medical University,Wuhan,China 430030
  • Received:1900-01-01 Revised:1900-01-01

摘要: 用我室仿国际标准C4定型程序改进后建立的方法及羧肽酶B处理后C4分型方法对湖北地区93 个无血缘关系的汉族家系进行C4单倍型的检测,对310个C4单倍型分析可见,我国汉族以A3B 1频率最高(0.4194),A3B2次之(0.1161),A2B1与A4B2均为0.0903。以下依次是AQOB1(0.0645 )、A3BQO(0.0548)、AQOBQO(0.0322)、A2B2(0.0256)、A4B1(0.0161)、A2B92(0.0129)等。 从连锁不平衡参(△)的卡方数值可见,A4B2、AQOBQO及A2B92具有极显著意义的阳性△值; 而A4B1与AQOB2则具有极显著意义的阴性△值。将我们的结果与日本人、美国及德国白人, 南非黑人的资料进行了对比,并进行了一些讨论。

关键词: 补体, C4, 单倍型, 单倍型, C4, 补体

Abstract: C4 baplotypes of 93 unrelated families of Han nationality in Hubei Province were determined by means of a method established in our laboratory based on the tech niques recommended in the 4th International WOrkshop for the Genetics of Complem ent and the method of Carboxype-ptidase B developed by Zhang in Australia.310 C4 haplotypes were analysed.The haplotype frequency of A3B1 (0.4194) was found to be the highest in Han nationality of Hubei in China.The others are as follows:A3 B2:0.1161,A2B1 and A4B2:both 0.0903,AQOB1:0.0645,A3BQO:0.0548,AQOBQO:0.0322,A2B2 :0.0256,A4B1:0.0161,A2B92:0.0129.Some kinds of rare haplotypes were also discove red.Significant positive-linkage disequilibrium parameters (Δ) were found in ha plotypes of A4B2,AQOBQO and A2B92,while the significant negative Δ was observed in that of A4B1 and AQOB2.Our data were compared with those of Japanese,Caucasi an in USA and Germany,Negroids in South Africa.are discussed in the paper The di fferences among them.

Key words: Haplotype, C4, Complement