摘要： 黑腹果蝇(Drosophila melanogaster)和秀丽隐杆线虫（Caeborhabditis elegans）的性别决定的问题已研究得比较详细，且transformer基因是这两种生物性别决定中最重要的基因之一，其有关的性别决定研究在近几年取得了很大的进展。本文就线虫和果蝇的transformer基因及其相关基因的特性与功能进行了特别介绍，并在此基础上对其性别决定的分子机制进行初步的比较和分析。Abstract : Sex determination of Drosophila melanogaster and Caeborhabditis elegans has been known in detail. Great progress, is achieved in recent years, is the research of transformer genes, which are those of most important genes in sex determination in both species. In this paper, molecular character, genetic function and the relative genes of transformer genes are particularly described. On the basis,a primary compariso and analysis between the molecular mechanism of sex determination in C.elegans and D. melanogaster are presented.