Hoxc13在毛囊发育中的作用

doi:10.3724/SP.J.1005.2010.00656

遗传 ›› 2010, Vol. 32 ›› Issue (7): 656-662.doi: 10.3724/SP.J.1005.2010.00656

Hoxc13在毛囊发育中的作用

吴江鸿^{1, 2}, 闫祖威^{2, 3}, 胡斯乐¹, 张文广^{1, 2}, 李金泉^{1, 2}

1. 内蒙古农业大学动物科学院, 呼和浩特 010018; 2. 内蒙古自治区动物遗传育种与繁殖重点实验室, 呼和浩特 010018; 3. 内蒙古农业大学理学院, 呼和浩特 010018

收稿日期:2009-10-10 修回日期:2010-01-30 出版日期:2010-07-20 发布日期:2010-07-20
通讯作者: 张文广;李金泉 E-mail:atcgnmbi@yahoo.com.cn;atcgnmbi@yahoo.com.cn
基金资助:
国家科技部项目(编号:2007AA10Z151, 2007BAD56B03, 30660122)资助

Hoxc13 and the development of hair follicle

WU Jiang-Hong^{1, 2}, YAN Zu-Wei^{2, 3}, Husile¹, ZHANG Wen-Guang^{1, 2}, LI Jin-Quan^{1, 2}

1. College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China; 2. Key Laboratory of Animal Genetics, Breeding and Reproduction of the Nei Mongol Autonomous Region, Hohhot 010018, China; 3. College of Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received:2009-10-10 Revised:2010-01-30 Online:2010-07-20 Published:2010-07-20
Contact: ZHANG Wen-Guang;LI Jin-Quan E-mail:atcgnmbi@yahoo.com.cn;atcgnmbi@yahoo.com.cn

摘要/Abstract

摘要： Hoxc13属于Hox(Homobox)基因家族Abd-B类成员之一, 与毛囊形成和毛发生长密切相关。毛发结构蛋白KP(角蛋白)和KAP(角蛋白关联蛋白)的表达都受Hoxc13的严格调控, Hoxc13表达水平会直接影响毛发的特性, 对维持毛囊的正常形态也至关重要。文章就Hoxc13的表达水平对毛囊发育和毛发生长的影响及Hoxc13与相关基因的调控进行了综述。

关键词: Hoxc13, 毛囊, 角蛋白/角蛋白关联蛋白, 基因通路

Abstract: Hoxc13 belongs to the Abd-B class of Hox gene family, which participated in the hair follicle formation and hair growth regulation process. The structural protein of hair KP (keratin) and KAP (keratin-associated protein) expression is under regulation of Hoxc13, and then changes the characteristics of hair by regulating the composition of these two types of hair proteins and maintaining the normal morphology of hair follicle. In this review, we summarized that the relationship between the expression level of Hoxc13 and hair follicle development/hair growth and the mechanisim under the controling of Hoxc13 and relevant genes.

Key words: Hoxc13, hair follicle, KP/KAP, genes pathway

吴江鸿，闫祖威，胡斯乐，张文广，李金泉. Hoxc13在毛囊发育中的作用[J]. 遗传, 2010, 32(7): 656-662.

TUN Jiang-Hong, YAN Jie-Wei, HU Shi-Le, ZHANG Wen-An, LI Jin-Quan. Hoxc13 and the development of hair follicle[J]. HEREDITAS, 2010, 32(7): 656-662.

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Hoxc13在毛囊发育中的作用

Hoxc13 and the development of hair follicle

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