表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景

doi:10.3724/SP.J.1005.2010.00663

遗传 ›› 2010, Vol. 32 ›› Issue (7): 663-669.doi: 10.3724/SP.J.1005.2010.00663

表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景

王晓铄, 俞英

中国农业大学动物科技学院, 北京 100193

收稿日期:2009-10-25 修回日期:2010-03-02 出版日期:2010-07-20 发布日期:2010-07-20
通讯作者: 俞英 E-mail:yuyingmaryland@yahoo.com
基金资助:
国家高技术研究发展计划项目(863计划)(编号：2008AA101002, 2008BADB2B03-05)和“948”项目(编号：2006-G48(3))资助

Regulation mechanisms of epigenetics on inflammation and its per-spective on breeding for mastitis resistance in dairy cattle

WANG Xiao-Shuo, YU Ying

College of Animal Science and Technology, China Agricultural University, Beijing 100193, China

Received:2009-10-25 Revised:2010-03-02 Online:2010-07-20 Published:2010-07-20
Contact: Ying Yu E-mail:yuyingmaryland@yahoo.com

摘要/Abstract

摘要： 炎症受遗传和非遗传因素(环境或表观遗传)的共同影响, 其中表观遗传(Epigenetic)在炎症的发生发展过程中发挥重要调控作用。表观遗传修饰是指DNA序列没有改变, 而基因表达却发生了可遗传的变化, 主要包括DNA甲基化和组蛋白修饰等。表观遗传为病原微生物与炎症反应间关系的研究架起了重要桥梁。炎症反应中T辅助细胞的分化, 细胞因子、趋化因子等基因的表达都受到表观遗传的调控。文章主要综述了DNA甲基化、组蛋白修饰等对炎症尤其是乳房炎的调控机制, 并就表观遗传调控在奶牛乳房炎治疗及抗病育种中的应用前景进行了展望。

关键词: 炎症, 表观遗传, 乳房炎, 抗病育种

Abstract: Inflammation is controlled by genetic and non-genetic factors (environment and epigenetics), within non-genetic factors, epigenetics play important roles in the development of inflammation. Epigenetic modifications, referring to changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence, mainly include DNA methylation and histone modification. Epigenetic study builds up the relationships between microorganism and inflammation. In inflammation responses, differentiation of T helper cells and gene expression of cytokine and chemokine are all regulated by epigenetics. Here, we reviewed the regulation mechanisms of DNA methylation and histone modifications on inflammation, especially on cow mastitis. The progress and application trends of epigenetics on treatment of mastitis and breeding for mastitis resistance in dairy cattle are also discussed.

Key words: Inflammation, epigenetics, mastitis, breeding for disease resistance

王晓铄，俞英. 表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景[J]. 遗传, 2010, 32(7): 663-669.

WANG Xiao-Li, SHU Yang. Regulation mechanisms of epigenetics on inflammation and its per-spective on breeding for mastitis resistance in dairy cattle[J]. HEREDITAS, 2010, 32(7): 663-669.

参考文献

[1] 张玉勤. 炎症与癌症. 国外医学情报, 2002, 1(23): 1–6. [2] Yu Y, Zhang H, Tian F, Bacon L, Zhang Y, Zhang W, Song J. Quantitative evaluation of DNA methylation patterns for ALVE and TVB genes in a neoplastic disease susceptible and resistant chicken model. PLoS ONE, 2008, 3(3): e1731. [3] Yu Y, Zhang H, Tian F, Zhang W, Fang H, Song J. An in-tegrated epigenetic and genetic analysis of DNA methyl-transferase genes (DNMTs) in tumor resistant and suscep-tible chicken lines. PLoS ONE, 2008, 3(7): e2672. [4] Vanselow J, Yang W, Herrmann J, Zerbe1 H, Schuberth HJ, Petzl W, Tomek W, Seyfert HM. DNA-remethylation around a STAT5-binding enhancer in the aS1-casein pro-moter is associated with abrupt shutdown of aS1-casein synthesis during acute mastitis. J Mol Endocrinol, 2006, 37(3): 463–477. [5] Tycko B. Epigenetic gene silencing in cancer. J Clin In-vest, 2000, 105 (4): 40l–407. [6] Kornberg RD, Lorch Y. Twenty-five years of the nu-cleosome, fundamental particle of the cukaryote chromo-some. Cell, 1999, 98(3): 285–294. [7] Shilatifard A. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem, 2006, 75: 243–269. [8] Lo PK, Sukumar S. Epigenomics and breast cancer. Pharmacogenomics, 2008, 9(12): 1879–1902. [9] Backdahl L, Bushell A, Beck S. Inflammatory signaling as mediator of epigenetic modulation in tissue-specific chronic inflammation. Int J Biochem Cell Biol, 2009, 41(1): 176–184. [10] 邹雄, 张利宁. 分子免疫学与临床. 山东: 山东科学技术出版社, 2003, 205–206. [11] Hutchins AS, Artis D, Hendrich BD, Bird AP, Scott P, Reiner SL. Cutting edge: a critical role for gene silencing in preventing excessive type 1 immunity. J Immunol, 2005, 175 (9): 5606–5610. [12] Lee GR, Kim ST, Spilianakis CG, Fields PE, Flavell RA. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity, 2006, 24 (4): 369–379. [13] Baguet A, Bix M. Chromatin landscape dynamics of the IL4-IL13 locus during T helper 1 and 2 development. Proc Natl Acad Sci, 2004, 101 (31): 11410–11415. [14] Saemann MD, Bohmig GA, Osterreicher CH, Burtscher H, Parolini O, Diakos C, Stockl J, Horl WH, Zlabinger GL. Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. FASEB J, 2000, 14 (15): 2380–2382. [15] Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol, 2006, 6(4): 329–333. [16] Pappu BP, Borodovsky A, Zheng TS, Yang X, Wu P, Dong X, Weng S, Browning B, Scott ML, Ma L, Su L, Tian Q, Schneider P, Flavell RA, Dong C, Burkly LC. TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med, 2005, (5): 1049–1062. [17] Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol, 2007, 179(4): 2041–2045. [18] Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet, 2001, 27 (1): 68–73. [19] Sakaguchi S, Ono M, Setoguchi R, Yagi H, Hori S, Fe-hervari Z, Shimizu J, Takahashi T, Nomura T. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev, 2006, 212(1): 8–27. [20] Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein-Hessling S, Serfling E, Hamann A, Huehn J. Epigenetic control of the foxp3 locus in

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

表观遗传对炎症的调控机制及其在奶牛乳房炎抗病育种中的应用前景

Regulation mechanisms of epigenetics on inflammation and its per-spective on breeding for mastitis resistance in dairy cattle

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	冒姝羽, 赵昌睿, 刘畅. 核受体REV-ERBα整合生物钟与能量代谢[J]. 遗传, 2023, 45(2): 99-114.
[2]	赵岩, 王晨鑫, 杨天明, 李春爽, 张丽宏, 杜冬妮, 王若曦, 王静, 魏民, 巴雪青. DNA氧化损伤8-羟鸟嘌呤与肿瘤的发生发展[J]. 遗传, 2022, 44(6): 466-477.
[3]	戴鸿宇, 季东, 谈程, 孙杰, 姚昊. 致病性Th17细胞在神经炎症中的作用及调控机制的研究进展[J]. 遗传, 2022, 44(4): 289-299.
[4]	曲卉, 柳毅, 陈雅文, 汪晖. 环境因素所致印迹基因改变与子代器官发育[J]. 遗传, 2022, 44(2): 107-116.
[5]	张杨景晖, 常沛瑶, 杨紫淑, 薛宇航, 李雪奇, 张旸. 表观遗传修饰影响花青苷合成研究进展[J]. 遗传, 2022, 44(12): 1117-1127.
[6]	赵清雯, 潘东宁. 表观遗传修饰对脂肪组织产热的调控进展[J]. 遗传, 2022, 44(10): 867-880.
[7]	何江平, 陈捷凯. 转座元件、表观遗传调控与细胞命运决定[J]. 遗传, 2021, 43(9): 822-834.
[8]	王雅楠, 徐涛, 王万鹏, 张庆祝, 解莉楠. 表观遗传修饰在作物重要性状形成中的作用[J]. 遗传, 2021, 43(9): 858-879.
[9]	袁洁, 蔡时青. 衰老过程中行为和认知功能退化的调控机制研究[J]. 遗传, 2021, 43(6): 545-570.
[10]	王天一, 王应祥, 尤辰江. 植物PHD结构域蛋白的结构与功能特性[J]. 遗传, 2021, 43(4): 323-339.
[11]	张向前, 李楠, 解新明. 表观遗传学综合性实验设计与探讨[J]. 遗传, 2021, 43(12): 1179-1187.
[12]	王娅洁, 吴爽爽, 储江, 孔祥阳. 肺部微生物组通过炎症反应介导慢性阻塞性肺疾病转化为肺癌的研究进展[J]. 遗传, 2021, 43(1): 30-39.
[13]	胡颖楚, 胡豪畅, 林少沂, 陈晓敏. DNA羟甲基化调控动脉粥样硬化的研究进展[J]. 遗传, 2020, 42(7): 632-640.
[14]	吴杰, 全建平, 叶勇, 吴珍芳, 杨杰, 杨明, 郑恩琴. 染色质转座酶可及性测序研究进展[J]. 遗传, 2020, 42(4): 333-346.
[15]	梅志超, 位竹君, 于佳慧, 冀凤丹, 解莉楠. 多组学关联分析揭示表观等位基因在拟南芥环境适应性进化中的作用及机制[J]. 遗传, 2020, 42(3): 321-331.