皮肤毛囊发育的转录组研究进展

doi:10.16288/j.yczz.14-440

遗传 ›› 2015, Vol. 37 ›› Issue (6): 528-534.doi: 10.16288/j.yczz.14-440

皮肤毛囊发育的转录组研究进展

江玮, 范一星, 乔贤, 张燕军, 刘志红, 赵艳红, 王瑞军, 王志新, 张文广, 苏蕊, 李金泉

内蒙古农业大学动物科学学院,动物遗传育种与繁殖内蒙古自治区实验室,呼和浩特 010018

收稿日期:2014-12-12 修回日期:2015-04-15 出版日期:2015-06-20 发布日期:2015-05-07
通讯作者: 李金泉,博士,教授,研究方向：绒山羊遗传育种。E-mail: lijinquan_nd@126.com
苏蕊,博士,讲师,研究方向：绒山羊遗传育种。E-mail: suruiyu@126.com
作者简介:江玮,硕士研究生,专业方向：动物遗传育种与繁殖。E-mail: jiangwei1022@163.com
基金资助:
国家高技术研究发展计划项目(863计划)(编号：2013AA102506),国家自然科学基金项目(编号：31201773,31260539,31272421),国家农业部现代农业产业技术体系项目(编号：CARS-40-05)和高等学校博士学科点专项科研基金项目(编号：20091515120010)资助

The transcriptome research progresses of skin hair follicle development

Wei Jiang, Yixing Fan, Xian Qiao, Yanjun Zhang, Zhihong Liu, Yanhong Zhao, Ruijun Wang, Zhixin Wang, Wenguang Zhang, Rui Su, Jinquan Li

Inner Mongolia Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Agricultural University, Hohhot 010018, China

Received:2014-12-12 Revised:2015-04-15 Online:2015-06-20 Published:2015-05-07

摘要/Abstract

摘要： 近年来,转录组测序技术在动物重要经济性状受复杂基因网络的调控研究领域取得了显著的成果。作为哺乳动物皮肤的衍生物,毛囊是唯一具有高度自我更新能力、独特的可再生器官,毛囊细胞经增殖分化最终形成毛发。已有的研究表明,诸多生长因子及其受体作为体内分泌协调基因的重要因素,对毛发的生长发育起着重要的调控作用。文章综述了近年来转录组测序技术在人、小鼠及羊等生物的皮肤毛囊发育和再生过程中基因调控方式的研究进展,旨在为今后人工干扰绒毛周期生长发育和分子育种提供理论依据,同时也为皮肤毛囊相关疾病的临床治疗提供新思路。

关键词: 毛囊, 转录组, 人, 小鼠, 羊

Abstract: Recently, transcriptome sequencing technology has achieved significant progresses in gene network regulation of important economic traits in animals. As the derivative of mammalian skin, hair follicle is capable of self-renew. Its proliferation and differentiation result in hair formation. Researches have revealed that many growth factors and receptors coordinate genes and environment, as well as play an extremely important role during hair growth. In this review, we summarize the progresses that transcriptome sequencing technologies have achieved in researches of hair follicle development and renegeration in a variety of species, such as humans, mice, goats. We aim to provide theoretical mechanisms for the artificial interference of villus growth cycle, and new ideas for therapeutic treatment of skin hair follicle- related diseases.

Key words: hair follicle, transcriptome, human, mice, goat

江玮, 范一星, 乔贤, 张燕军, 刘志红, 赵艳红, 王瑞军, 王志新, 张文广, 苏蕊, 李金泉. 皮肤毛囊发育的转录组研究进展[J]. 遗传, 2015, 37(6): 528-534.

Wei Jiang, Yixing Fan, Xian Qiao, Yanjun Zhang, Zhihong Liu, Yanhong Zhao, Ruijun Wang, Zhixin Wang, Wenguang Zhang, Rui Su, Jinquan Li. The transcriptome research progresses of skin hair follicle development[J]. HEREDITAS(Beijing), 2015, 37(6): 528-534.

参考文献

[1] Oro AE, Scott MP. Splitting hairs: dissecting roles of signalling systems in epidermal development. Cell , 1998, 95(5): 575-578.
[2] Hardy MH. The secret life of the hair follicle. Trends Genet , 1992, 8(2): 55-61.
[3] Galbraith H. Fundamental hair follicle biology and fine fibre production in animals. Animal , 2010, 4(9): 1490-1509.
[4] Rogers GE. Biology of the wool follicle: An excursion into a unique tissue interaction system waiting to be re-discovered. Exp Dermatol , 2006, 15(12): 931-949.
[5] 王宁, 荣恩光, 闫晓红. 毛囊发育与毛发生产研究进展. 东北农业大学学报, 2012, 43(9): 6-11.
[6] Yang CC, Cotsarelis G. Review of hair follicle dermal cells. J Dermatol Sci , 2010, 57(1): 2-11.
[7] Lien WH, Polak L, Lin MY, Lay K, Zheng DY, Fuchs E. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol , 2014, 16(2): 179-190.
[8] Mardaryev AN, Ahmed MI, Vlahov NV, Fessing MY, Gill JH, Sharov AA, Botchkareva NV. Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J , 2010, 24(10): 3869-3881.
[9] Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom A, Chung CY, Cai XQ, Cai CL, Pevny L, Nicolis S, Ma’ayan A, Rendl M. Sox2 in the dermal papilla niche controls hair growth by fine tuning BMP signalling in differentiating hair shaft progenitors. Dev Cell , 2012, 23(5): 981-994.
[10] Hwang J, Mehrani T, Millar SE, Morasso MI. Dlx3 is a crucial regulator of hair follicle differentiation and regeneration. Development , 2008, 135(18): 3149-3159.
[11] Kurek D, Garinis GA, van Doorninck JH, van der Wees J, Grosveld FG. Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles. Development , 2007, 134(2): 261-272.
[12] Keyes BE, Segal JP, Heller E, Lien WH, Chang CY, Guo XY, Oristian DS, Zheng DY, Fuchs E. Nfatc1 orchestrates aging in hair follicle stem cells. Proc Natl Acad Sci USA , 2013, 110(51): E4950-E4959.
[13] 吴萍. Notch信号通路与绒山羊绒毛生长的研究[学位论文]. 呼和浩特: 内蒙古农业大学, 2010.
[14] Pispa J, Pummila M, Barke PA, Thesleff I, Mikkola ML. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet , 2008, 17(21): 3380-3391.
[15] de Schellenberger AA, Horland R, Rosowski M, Paus R, Lauster R, Lindner G. Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles. Exp Dermatol , 2011, 20(4): 361-366.
[16] 蔡婷, 刘志红, 王志新, 赵濛, 俎红丽, 李金泉. miRNA在调控皮肤和毛囊发育中的作用. 遗传, 2013, 35(9): 1087-1094.
[17] Schmidt-Ullrich R, Paus R. Molecular principles of hair follicle induction and morphogenesis. Bioessays , 2005, 27(3):247-261.
[18] Sun FY, Wang JY, Pan QH, Yu YC, Zhang Y, Wan Y, Wang J, Li XY, Hong A. Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun , 2009, 380(3): 660-665.
[19] Mecklenburg L, Tobin DJ, Muller-Rover S, Handjiski B, Wendt G, Peters EMJ, Pohl S, Moll I, Paus R. Active hair growth (anagen) is associated with angiogenesis. J Invest Dermatol , 2000, 114(5): 909-916.
[20] Pedrioli DML, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin JW, Marino D, Kälin RE, Leidel S, Cinelli P, Schulte-Merker S, Brändli AW, Detmar M. miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo . Mol Cell Biol , 2010, 30(14): 3620-3634.
[21] Zhu B, Xu T, Yuan JL, Guo XD, Liu DJ. Transcriptome sequencing reveals differences between primary and secondary hair follicle-derived dermal papilla cells of the Cashmere goat ( Capra hircus ). PLoS One , 2013, 8(9): e76282.
[22] Zhang WG, Wang JH, Li JQ, Yashizawa M. A subset of skin-expressed microRNAs with possible roles in goat and sheep hair growth based on expression profiling of mammalian microRNAs. Omics , 2007, 11(4): 385-396.
[23] Yuan C, Wang XL, Geng RQ, He XL, Qu L, Chen YL. Discovery of cashmere goat ( Capra hircus ) microRNAs in skin and hair follicles by Solexa sequencing. BMC Genomics , 2013, 14: 511.
[24] 常子丽. 皮肤毛囊基因调控网络的初建及其在绒山羊上的功能预测[学位论文]. 呼和浩特: 内蒙古农业大学, 2007.
[25] Ahn SY, Pi LQ, Hwang ST, Lee WS. Effect of IGF-I on hair growth is related to the anti-apoptotic effect of IGF-I and up-regulation of PDGF-A and PDGF-B. Ann Dermatol , 2012, 24(1): 26-31.
[26] Leishman E, Howard JM, Garcia GE, Miao Q, Ku AT, Dekker JD, Tucker H, Nguyen H. Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. Development , 2013, 140(18): 3809-3818.
[27] Panteleyev AA, Paus R, Christiano AM. Patterns of hairless (hr) gene expression in mouse hair follicle morphogenesis and cycling. Am J Pathol , 2000, 157(4): 1071-1079.
[28] Botchkarev VA, Komarova EA, Siebenhaar F, Botchkareva NV, Sharov AA, Komarov PG, Maurer M, Gudkov AV, Gilchrest BA. p53 Involvement in the control of murine hair follicle regression. Am J Pathol , 2001, 158(6): 1913-1919.
[29] 王琳. 褪黑激素对内蒙古绒山羊毛囊生长发育相关基因的影响[学位论文]. 呼和浩特: 内蒙古农业大学, 2014.
[30] 刘斌. 绒山羊绒毛生长相关基因的筛选、鉴定和多态性分析[学位论文]. 呼和浩特: 内蒙古农业大学, 2012.
[31] 吴江鸿. Hoxc13 基因在绒山羊皮肤中的表达规律及体外功能分析[学位论文]. 呼和浩特: 内蒙古农业大学, 2011.
[32] 贺建宁, 刘鲁梅, 程明, 刘开东, 于维敏, 刘积凤, 赵金山, 柳楠. 敖汉细毛羊毛囊FGF10、FGF18和FGFR3基因差异表达的研究. 第六届全国动植物数量遗传学学术研讨会, 2014, 55.
[33] Oro AE, Higgins K. Hair cycle regulation of Hedgehog signal reception. Develop Biol , 2003, 255(2): 238-248.
[34] Grachtchouk M, Pero J, Yang SH, Ermilov AN, Michael LE, Wang AQ, Wilbert D, Patel RM, Ferris J, Diener J, Allen M, Lim S, Syu LJ, Verhaegen M, Dlugosz AA. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest , 2011, 121(5): 1768-1781.
[35] Brancaccio A, Minichiello A, Grachtchouk M, Antonini D, Sheng H, Parlato R, Dathan N, Dlugosz AA, Missero C. Requirement of the fork head gene Foxe1 , a target of sonic hedgehog signaling, in hair follicle morphogenesis. Hum Mol Genet , 2004, 13(21): 2595-2606.
[36] Oda Y, Hu LZ, Bul V, Elalieh H, Reddy JK, Bikle DD. Coactivator MED1 ablation in keratinocytes results in hair-cycling defects and epidermal alternations. J Invest Dermatol , 2012, 132(4): 1075-1083.
[37] Cui CY, Hashimoto T, Grivennikov SI, Piao YL, Nedospasov SA, Schlessinger D. Ectodysplasin regulates the lymphotoxin-β pathway for hair differentiation. Proc Natl Acad Sci USA , 2006, 103(24): 9142-9147.
[38] Nagao K, Kobayashy T, Ohyama M, Akiyama H, Horiuchi K, Amagai M. Brief report: requirement of TACE/ADAM17 for hair follicle bulge niche establishment. Stem Cells , 2012, 30(8): 1781-1785.
[39] Mardaryev AN, Meier N, Poterlowicz K, Sharov AA, Sharova TY, Ahmed MI, Rapisarda V, Lewis C, Fessing MY, Ruenger TM, Bhawan J, Werner S, Paus R, Botchkarev VA. Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development , 2011, 138(22): 4843-4852.
[40] Fantauzzo KA, Kurban M, Levy B, Christiano AM. Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. PLoS Genet , 2012, 8(11): e1003002.

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

皮肤毛囊发育的转录组研究进展

The transcriptome research progresses of skin hair follicle development

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	卢涣滋,王迪侃,王智. HPV阳性口咽癌患者预后与T细胞浸润和新抗原负荷相关性分析[J]. 遗传, 2019, 41(8): 725-735.
[2]	郑建敏,罗江陶,万洪深,李式昭,杨漫宇,李俊,杨恩年,蒋云,刘于斌,王相权,蒲宗君. 四川省小麦育成品种系谱分析及发展进程[J]. 遗传, 2019, 41(7): 599-610.
[3]	赵志达,张莉. 基因组选择在绵羊育种中的应用[J]. 遗传, 2019, 41(4): 293-303.
[4]	石田培,张莉. 全转录组学在畜牧业中的应用[J]. 遗传, 2019, 41(3): 193-205.
[5]	刘钟颖,黄霞,李紫怡,杨子豪,袁白银. 肌动蛋白细胞骨架在小鼠第二生心区祖细胞部署发育中的作用[J]. 遗传, 2019, 41(2): 125-136.
[6]	张高华, 于树涛, 王鹤, 王旭达. 高油酸花生发芽期低温胁迫转录组及差异表达基因分析[J]. 遗传, 2019, 41(11): 1050-1059.
[7]	王凤红,张磊,李晓凯,范一星,乔贤,龚高,严晓春,张令天,王志英,王瑞军,刘志红,王志新,何利兵,张燕军,李金泉,赵艳红,苏蕊. 山羊基因组研究进展[J]. 遗传, 2019, 41(10): 928-938.
[8]	张豪, 张志鹏, 郭晓东, 马敏, 敖月, 刘旭, 马小燕, 梁浩, 郭旭东. cgVEGF164基因对小鼠毛囊生长的影响[J]. 遗传, 2019, 41(1): 76-84.
[9]	赵学彤, 杨亚东, 渠鸿竹, 方向东. 组学时代下机器学习方法在临床决策支持中的应用[J]. 遗传, 2018, 40(9): 693-703.
[10]	胡广东,郝科兴,黄涛,曾维斌,谷新利,王静. 绵羊高效转基因通用型piggyBac转座子载体构建及功能验证[J]. 遗传, 2018, 40(8): 647-656.
[11]	黄耀强,李国玲,杨化强,吴珍芳. 基因编辑猪在生物医学研究中的应用[J]. 遗传, 2018, 40(8): 632-646.
[12]	夏青, 刘秋月, 王翔宇, 胡文萍, 李春艳, 贺小云, 储明星, 狄冉. 绵羊季节性繁殖分子机制及休情季节诱导绵羊发情配种技术[J]. 遗传, 2018, 40(5): 369-377.
[13]	孟晓伟, 汪洁, 马晴雯. 唐氏综合征小鼠模型的遗传背景和应用[J]. 遗传, 2018, 40(3): 207-217.
[14]	谢晶, 范辰, 张景龙, 张仕强. Ash2l-1/Ash2l-2在小鼠胚胎干细胞中的表达特异性及互补效应[J]. 遗传, 2018, 40(3): 237-249.
[15]	李夏, 滑慧娟, 郝捷, 王柳, 刘忠华. 利用微载体悬浮培养人脐带间充质干细胞[J]. 遗传, 2018, 40(12): 1120-1128.