遗传 ›› 2011, Vol. 33 ›› Issue (11): 1159-1163.doi: 10.3724/SP.J.1005.2011.01159

• 综述 • 上一篇    下一篇

心脏的再生性研究进展

甄一松 , 惠汝太, 熊敬维   

  1. 1. 中国医学科学院北京协和医学院阜外心血管病医院心血管病研究所, 心血管转化医学国家重点实验室, 北京 100037 2. 北京大学分子医学所心血管发育学研究室, 北京 100871
  • 收稿日期:2010-12-23 修回日期:2011-03-23 出版日期:2011-11-20 发布日期:2011-11-25
  • 通讯作者: 甄一松 E-mail:zhenyisong@cardiosignal.org
  • 基金资助:

    国家自然科学基金项目(编号:31000644)资助

Recent progress in heart regeneration

ZHEN Yi-Song1, HUI Ru-Tai1, XIONG Jing-Wei2   

  1. 1. State Key Laboratory of Translational Cardiovascular Medicine, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China 2. Laboratory of Cardiovascular Development & Regeneration, Institute of Molecular Medicine, Peking University, Beijing 100871, China
  • Received:2010-12-23 Revised:2011-03-23 Online:2011-11-20 Published:2011-11-25
  • Contact: ZHEN Yi-Song E-mail:zhenyisong@cardiosignal.org

摘要: 心力衰竭(心衰)是由多种心血管疾病引起的心功能不全, 最终出现心肌局部坏死和不可逆转的纤维化。传统的药物治疗、介入和外科治疗方案都存在着一定的局限性。随着转化医学的发展, 心脏再生和修复无疑是解决以上临床问题的最佳方案, 基础研究的成果正在为临床实践提供理论基础。文章从心脏再生性修复策略、心肌细胞来源、重编程和模式动物等几个方面的进展概括了整个心脏再生领域的发展。

关键词: 心脏发育, 心脏再生, 模式动物, 心肌梗塞

Abstract: Heart failure (CHF) is the direct cause of death of a variety of cardiovascular diseases, culminating in irreversible myocardial necrosis and fibrosis. Traditional drug treatment, intervention, and surgical treatment have their own limitations. Increasing cardiac regeneration and repair of the injured heart is undoubtedly a promising approach to solve these clinical problems. In this paper, we summarized recent progress of heart development and regeneration, highlighting potential involvement of cell proliferation, dedifferentiation and cell reprogramming. We also proposed several fundamental and important research directions in this exciting area.

Key words: heart development, cardiac regeneration, model animal, myocardial infarction